Presidents Dining Room, Old Student Union, Chapman College, Orange, California

Presidents Dining Room, old Student Union, Chapman College, Orange, California. Furniture is from the Rankin estate; moved from the Grace Rankin Lounge in Memorial Hall.

Patio area of the old Student Union, Chapman College, Orange, California

Patio area of the old Student Union, Chapman College, Orange, California. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Hungrey Panther entrance at the old Student Union, Chapman College, Orange, California

Hungrey Panther entrance at the old Student Union, Chapman College, Orange, California. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Old Student Union patio remodel, Chapman College, Orange, California

Old Student Union patio remodel in progress, Chapman College, Orange, California. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Old Student Union patio remodel, Chapman College, Orange, California

Old Student Union patio remodel in progress, Chapman College, Orange, California, 1973. Signage on building also part of the campus renewal. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Old Student Union building and patio remodel, Chapman College, Orange, California

Old Student Union building and patio remodel, Chapman College, Orange, California, 1973. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Renovating the old Student Union patio, Chapman College, Orange, California

Renovating the old Student Union patio, Chapman College, Orange, California, 1973. The Australian tea trees were moved from the music building site. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Renovating the old Student Union patio, Chapman College, Orange, California, 1973

Renovating the old Student Union patio, Chapman College, Orange, California, 1973. The Australian tea trees were moved from the music building site. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Painting signage on old Student Union, Chapman College, Orange, California

Painting signage on old Student Union, Chapman College, Orange, California, as part of a campus renewal project in 1973. Originally the manual arts building and bus repair garage for Orange Union High School. Building annex additions through 1975 increased the size to 19,680 sq. ft. Used as a student union by Chapman College. In 1996 the building became the Cecil B. DeMille Hall, housing the Film and TV department.

Wilkinson Hall, Chapman College, Orange, California

People outside on the grass by Wilkinson Hall, Chapman College, Orange, California. J.E. Wilkinson was a former trustee, chairman of the board, and acting president. This building was the first on the campus of Orange Union High Schooi, designed by local architect, C.B. Bradshaw and constructed in 1905 by R. J. Noble. In 1921 it was moved 250 feet and turned 90 degrees to its current location. Acquired in 1954 by Chapman College. it houses the Provost’s office, Academic Affairs, English & Comparative Literature, Graduate Studies, and the departments of Religion and Philosophy. It is listed in the National Registry for Historical Buildings.

View overlooking the Hutton Sports Complex at Chapman College, Orange, California

View from Hashinger Hall overlooking the Hutton Sports Complex at Chapman College, Orange, California, 1979. Rooftops of residences and trees in the foreground; the stadium and athletics field in the background.

First building of Orange Union High School, Orange, California, now Wilkinson Hall, Chapman University

Orange Union High School, located at 333 N. Glassell Street, Orange, California, 1905. Constructed in 1905 and designed by local architect, C.B. Bradshaw, image shows main building, now called Wilkinson Hall, which moved north prior to 1921. Acquired in 1954 and currently operated by Chapman University; it was renamed Wilkinson Hall in honor of J. E. Wilkinson, a former trustee, chairman of the board, and acting president. View shows front and south elevations across North Glassell Street.

Wilkinson Hall, Chapman College, Orange, California

Wilkinson Hall, 301 N. Orange Street, Chapman College, Orange, California. J.E. Wilkinson was a former trustee, chairman of the board, and acting president. This building was the first on the campus of Orange Union High Schooi, designed by local architect, C.B. Bradshaw and constructed in 1905 by R. J. Noble. In 1921 it was moved 250 feet and turned 90 degrees to its current location. Acquired in 1954 by Chapman College. it houses the Provost’s office, Academic Affairs, English & Comparative Literature, Graduate Studies, and the departments of Religion and Philosophy. It is listed in the National Registry for Historical Buildings.

Cholesterol-Independent Effects of Methyl-b- Cyclodextrin on Chemical Synapses

The cholesterol chelating agent, methyl-b-cyclodextrin (MbCD), alters synaptic function in many systems. At crayfish neuromuscular junctions, MbCD is reported to reduce excitatory junctional potentials (EJPs) by impairing impulse propagation to synaptic terminals, and to have no postsynaptic effects. We examined the degree to which physiological effects of MbCD correlate with its ability to reduce cholesterol, and used thermal acclimatization as an alternative method to modify cholesterol levels. MbCD impaired impulse propagation and decreased EJP amplitude by 40% (P,0.05) in preparations from crayfish acclimatized to 14uC but not from those acclimatized to 21uC. The reduction in EJP amplitude in the cold-acclimatized group was associated with a 49% reduction in quantal content (P,0.05). MbCD had no effect on input resistance in muscle fibers but decreased sensitivity to the neurotransmitter L-glutamate in both warm- and coldacclimatized groups. This effect was less pronounced and reversible in the warm-acclimatized group (90% reduction in cold, P,0.05; 50% reduction in warm, P,0.05). MbCD reduced cholesterol in isolated nerve and muscle from cold- and warmacclimatized groups by comparable amounts (nerve: 29% cold, 25% warm; muscle: 20% cold, 18% warm; P,0.05). This effect was reversed by cholesterol loading, but only in the warm-acclimatized group. Thus, effects of MbCD on glutamatesensitivity correlated with its ability to reduce cholesterol, but effects on impulse propagation and resulting EJP amplitude did not. Our results indicate that MbCD can affect both presynaptic and postsynaptic properties, and that some effects of MbCD are unrelated to cholesterol chelation.