An approach version of fuzzy metric spaces including an ad hoc fixed point theorem

In this paper, inspired by two very different, successful metric theories such us the real view-point of Lowen's approach spaces and the probabilistic field of Kramosil and Michalek's fuzzymetric spaces, we present a family of spaces, called fuzzy approach spaces, that are appropriate to handle, at the same time, both measure conceptions. To do that, we study the underlying metric interrelationships between the above mentioned theories, obtaining six postulates that allow us to consider such kind of spaces in a unique category. As a result, the natural way in which metric spaces can be embedded in both classes leads to a commutative categorical scheme. Each postulate is interpreted in the context of the study of the evolution of fuzzy systems. First properties of fuzzy approach spaces are introduced, including a topology. Finally, we describe a fixed point theorem in the setting of fuzzy approach spaces that can be particularized to the previous existing measure spaces.

Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells

Background Ubiquitination is known to regulate physiological neuronal functions as well as to be involved in a number of neuronal diseases. Several ubiquitin proteomic approaches have been developed during the last decade but, as they have been mostly applied to non-neuronal cell culture, very little is yet known about neuronal ubiquitination pathways in vivo. Methodology/Principal Findings Using an in vivo biotinylation strategy we have isolated and identified the ubiquitinated proteome in neurons both for the developing embryonic brain and for the adult eye of Drosophila melanogaster. Bioinformatic comparison of both datasets indicates a significant difference on the ubiquitin substrates, which logically correlates with the processes that are most active at each of the developmental stages. Detection within the isolated material of two ubiquitin E3 ligases, Parkin and Ube3a, indicates their ubiquitinating activity on the studied tissues. Further identification of the proteins that do accumulate upon interference with the proteasomal degradative pathway provides an indication of the proteins that are targeted for clearance in neurons. Last, we report the proof-of-principle validation of two lysine residues required for nSyb ubiquitination. Conclusions/Significance These data cast light on the differential and common ubiquitination pathways between the embryonic and adult neurons, and hence will contribute to the understanding of the mechanisms by which neuronal function is regulated. The in vivo biotinylation methodology described here complements other approaches for ubiquitome study and offers unique advantages, and is poised to provide further insight into disease mechanisms related to the ubiquitin proteasome system.

Manuel Bandeira nas cartas e nas crônicas: percurso literário e arte poética

Este trabalho é um exercício reflexivo sobre o percurso literário e a arte poética de Manuel Carneiro de Souza Bandeira Filho nos decênios de 1920 e 1930. Na leitura da correspondência trocada por ele e Mário Raul de Morais Andrade, e de seus textos escritos para a imprensa, buscamos analisar as múltiplas feições assumidas pelo poeta pernambucano e procuramos desentranhar traços gerais de sua concepção de vida e de poesia. Deste modo, na presente dissertação, o gênero epistolar e a crônica são considerados como notáveis objetos de estudo para a literatura brasileira. A correspondência com Mário de Andrade adquire relevo na produção intelectual de Manuel Bandeira, pois ela possibilita um maior entendimento do poeta a partir de sua escrita de si, assim como permite observar a preocupação do escritor com a memória da cultura brasileira. Da mesma forma, a crônica torna-se importante porque traz o testemunho do cronista sobre o tempo circundante. Ao percorremos uma parte significativa da prosa de Manuel Bandeira, estabelecemos o cotejo com o seu texto memorialístico Itinerário de Pasárgada, rastreando, nessas fontes, os escritos que denunciam o seu posicionamento em relação às inovações da arte moderna

Ictiólogos de la Argentina: Aurelio Juan Santiago Pozzi

This series will include all those people who, by means of their contributions, great and small, played a part in the consolidation of ichthyology in Argentina. The general plan of this work consists of individual factsheets containing a list of works by each author, along with reference bibliography and, whenever possible, personal pictures and additional material. The datasheets will be published primarily in chronological order, although this is subject to change by the availability of materials for successive editions. This work represents another approach for the recovery and revalorization of those who set the foundations of Argentine ichthyology while in diverse historical circumstances. I expect this to be the beginning of a major work that achieves the description of such a significant part of the history of natural sciences in Argentina.

Lista de los peces de la provincia de San Juan

Esta serie tiene como finalidad dar a conocer las especies presentes en los diferentes estados provinciales. Tomando como base los trabajos de López et al., (2003); Reis et al., (2003); Liotta (2006) y Ferraris (2007) hemos actualizado el elenco ictiofaunístico en cada territorio provincial, siguiendo la macrosistemática de Nelson (2006). No se realizan, con excepción del nombre vulgar y localidad tipo, comentarios ni observaciones sobre las especies señaladas ya que estos se encuentran en la bibliografía adjunta. Se incluyen dos tablas que contienen información sobre especies introducidas y de aquellas de presencia dudosa o que requieren confirmación en el territorio provincial. En este último caso se cita el trabajo que las menciona por primera vez. Consideramos que este modesto aporte contribuirá a precisar el conocimiento ictiofaunístico regional ya que además de la lista de especies, presentamos el marco biogeográfico e hídrico correspondiente. Por otra parte, entendemos que la participación de autores involucrados en la región considerada, le da un verdadero sentido federal a esta contribución, además de reforzar vínculos entre los protagonistas de nuestra especialidad. En este nuevo número, presentamos la provincia de San Juan que se encuentra enclavada en el centro-oeste de nuestro territorio, limitada por las provincias de La Rioja, Mendoza y San Luis. Se presenta por primera vez una lista exhaustiva de la ictiofauna de la provincia de San Juan basada en la revisión bibliográfica y de material de referencia de las colecciones Ictiológicas de la Universidad Nacional de San Juan y del Museo de La Plata. Se citan 21 especies, de las cuales 15 no habían sido mencionadas con anterioridad (Arratia et al., 1983; Murúa y Acosta, 1997; Liotta, 2006). Ocho especies han sido introducidas principalmente con fines deportivos. Se menciona la presencia de Percichthys chilensis, lo que constituiría el primer registro formal de esta especie ya que López-Arbarello (2004) la menciona para el Río Tunuyán (Mendoza), sin material de referencia.

Ictiólogos de la Argentina: Juan Carlos Vidal

This series will include all those people who, by means of their contributions, great and small, played a part in the consolidation of ichthyology in Argentina. The general plan of this work consists of individual factsheets containing a list of works by each author, along with reference bibliography and, whenever possible, personal pictures and additional material. The datasheets will be published primarily in chronological order, although this is subject to change by the availability of materials for successive editions. This work represents another approach for the recovery and revalorization of those who set the foundations of Argentine ichthyology while in diverse historical circumstances. I expect this to be the beginning of a major work that achieves the description of such a significant part of the history of natural sciences in Argentina.

Semblanzas Ictiológicas: Juan Martín Díaz de Astarloa

A través de esta serie intentaremos conocer diferentes facetas personales de los integrantes de nuestra “comunidad”. El cuestionario, además de su principal objetivo, con sus respuestas quizás nos ayude a encontrar entre nosotros puntos en común que vayan más allá de nuestros temas de trabajo y sea un aporte a futuros estudios históricos. Esperamos que esta iniciativa pueda ser otro nexo entre los ictiólogos de la región, ya que consideramos que el resultado general trascendería nuestras fronteras.

Fish consumption by harbor seals (Phoca vitulina) in the San Juan Islands, Washington

The harbor seal (Phoca vitulina) is a large-bodied and abundant predator in the Salish Sea ecosystem, and its population has recovered since the 1970s after passage of the Marine Mammal Protection Act and the cessation of bounties. Little is known about how this large predator population may affect the recovery of fish stocks in the Salish Sea, where candidate marine protected areas are being proposed. We used a bioenergetics model to calculate baseline consumption rates in the San Juan Islands, Washington. Salmonids (Oncorhynchus spp.) and herring (Clupeidae) were the 2 most energetically important prey groups for biomass consumed by harbor seals. Estimated consumption of salmonids was 783 (±380 standard deviation [SD]) metric tons (t) in the breeding season and 675 (±388 SD t in the nonbreeding season. Estimated consumption of herring was 646 (±303 SD) t in the breeding season and 2151 (±706 SD) t in the nonbreeding season. Rockfish, a depressed fish stock currently in need of population recovery, composed one of the minor prey groups consumed by harbor seals (84 [±26 SD] t in the nonbreeding season). The variables of seal body mass and proportion of prey in seal diet explained >80% of the total variation in model outputs. Prey groups, such as rockfish, that are targeted for recovery may still be affected by even low levels of predation. This study highlights the importance of salmonids and herring for the seal population and provides a framework for refining consumption estimates and their confidence intervals with future data.

Semblanzas Ictiológicas: Manuel Fabián Grosman

A través de esta serie intentaremos conocer diferentes facetas personales de los integrantes de nuestra “comunidad”. El cuestionario, además de su principal objetivo, con sus respuestas quizás nos ayude a encontrar entre nosotros puntos en común que vayan más allá de nuestros temas de trabajo y sea un aporte a futuros estudios históricos. Esperamos que esta iniciativa pueda ser otro nexo entre los ictiólogos de la región, ya que consideramos que el resultado general trascendería nuestras fronteras.

Semblanzas Ictiológicas: Juan José Rosso

A través de esta serie intentaremos conocer diferentes facetas personales de los integrantes de nuestra “comunidad”. El cuestionario, además de su principal objetivo, con sus respuestas quizás nos ayude a encontrar entre nosotros puntos en común que vayan más allá de nuestros temas de trabajo y sea un aporte a futuros estudios históricos. Esperamos que esta iniciativa pueda ser otro nexo entre los ictiólogos de la región, ya que consideramos que el resultado general trascendería nuestras fronteras.

Luis Manuel López

A mes y medio de mi jubilación presento este artículo que para mí era una de las tantas deudas pendientes, pero ésta en particular acentuaba mi sentido de pertenencia. Se trata de un artísta prácticamente desconocido nacido en Ciudad Autónoma de Buenos Aires el 16 de julio de 1921 y fallecido en la misma ciudad el 26 de julio de 1995. Por cuestiones de vida, que no viene al caso mencionar, dejó de lado su verdadera vocación como principal labor y casi sin preparación previa la llevó a cabo como hobby sólo en su tiempo libre. Me pregunto cómo hubiera sido su producción artística o hasta dónde habría llegado si hubiera estudiado en alguna escuela de arte o practicado en algún reconocido atelier. No es de mi conocimiento que haya expuesto y estoy segura que de haberlo hecho, público y jurados se habrían enamorado como yo de sus pinturas y dibujos. Demuestra su habilidad y capacidad innatas, dones reservados para unos pocos, y su voluntad de plasmar lo que evidentemente le emanaba desde sus entrañas. Aquí se presentan parte de, a mi criterio, sus excelentes obras, complementadas con imágenes de él y de su contexto afectivo. No se dispone del nombre, año de realización y/o técnica utilizada de algunas de ellas, y muchas otras lamentablemente se perdieron o fueron donadas sin ser fotografiadas. Debo aclarar que Hugo López no me permitía editarlo porque consideraba que no correspondía por tratarse de su padre. Ante mi insistencia, recién ahora asintió, pidiéndome que yo fuera la única responsable. Pronta acepté antes de que se arrepienta y por ello, aparezco como única compiladora. Es mi esperanza que se conozca en el mayor grado posible el enorme artista contenido en este hombre que en soledad pintaba o dibujaba principalmente para él mismo, y luego, para su entorno, sin poder concretar mayores aspiraciones. Si es cierto que, como algunos dicen, cuando alguien ya no está nos observa desde alguna parte del universo, estoy segurísima que se sentirá un poco recompensado y esbozará una sonrisa de satisfacción.

Valve surgery in active infective endocarditis: a simple score to predict in-hospital prognosis

Aims Surgery for infective endocarditis (IE) is associated with high mortality. Our objectives were to describe the experience with surgical treatment for IE in Spain, and to identify predictors of in-hospital mortality. Methods Prospective cohort of 1000 consecutive patients with IE. Data were collected in 26 Spanish hospitals. Results Surgery was performed in 437 patients (43.7%). Patients treated with surgery were younger and predominantly male. They presented fewer comorbid conditions and more often had negative blood cultures and heart failure. In-hospital mortality after surgery was lower than in the medical therapy group (24.3 vs 30.7%, p = 0.02). In patients treated with surgery, endocarditis involved a native valve in 267 patients (61.1%), a prosthetic valve in 122 (27.9%), and a pacemaker lead with no clear further valve involvement in 48 (11.0%). The most common aetiologies were Staphylococcus (186, 42.6%), Streptococcus (97, 22.2%), and Enterococcus (49, 11.2%). The main indications for surgery were heart failure and severe valve regurgitation. A risk score for in-hospital mortality was developed using 7 prognostic variables with a similar predictive value (OR between 1.7 and 2.3): PALSUSE: prosthetic valve, age ≥ 70, large intracardiac destruction, Staphylococcus spp, urgent surgery, sex [female], EuroSCORE ≥ 10. In-hospital mortality ranged from 0% in patients with a PALSUSE score of 0 to 45.4% in patients with PALSUSE score > 3. Conclusions The prognosis of IE surgery is highly variable. The PALSUSE score could help to identify patients with higher in-hospital mortality.

Influence of depression in a sample of people with hallux valgus

Hallux valgus (HV) is a highly-prevalent forefoot deformity associated with progressive subluxation and osteoarthritis of the first metatarsophalangeal joint; it is believed to be associated with depression. The aim of the present study was to determine the association of patients with varying degrees of HV involvement to depression using the Beck Depression Inventory (BDI). The sample consisted of 102 participants (mean age: 45.1±1.6), who attended an outpatient centre where self-report data were recorded. The degree of HV deformity was determined in both feet, and the scores on the BDI were compared. A total of 38.24% of the sample had depression, with an average BDI score of 10.55±12.36 points. There was a statistically-significant association between the degree and presence of HV in both feet (P=0.0001). People with a greater degree of HV deformity in any foot also have a significant increase in depression based on BDI scores, regardless of sex.