Storia degli israeliti dai tempi più antichi sino al presente : ad uso scolastico e domestico

di Daniele Ehrmann. Prima versione ital. di S. R. Melli

Ideografia semitica e trasformazione della radice ebraica nelle lingue indo-europee

Giuseppe Barzilai

Elevated AST-to-platelet ratio index is associated with increased all-cause mortality among HIV-infected adults in Zambia.

BACKGROUND AND AIMS We investigated the association between significant liver fibrosis, determined by AST-to-platelet ratio index (APRI), and all-cause mortality among HIV-infected patients prescribed antiretroviral therapy (ART) in Zambia METHODS: Among HIV-infected adults who initiated ART, we categorized baseline APRI scores according to established thresholds for significant hepatic fibrosis (APRI ≥1.5) and cirrhosis (APRI ≥2.0). Using multivariable logistic regression we identified risk factors for elevated APRI including demographic characteristics, body mass index (BMI), HIV clinical and immunologic status, and tuberculosis. In the subset tested for hepatitis B surface antigen (HBsAg), we investigated the association of hepatitis B virus co-infection with APRI score. Using Kaplan-Meier analysis and Cox proportional hazards regression we determined the association of elevated APRI with death during ART. RESULTS Among 20,308 adults in the analysis cohort, 1,027 (5.1%) had significant liver fibrosis at ART initiation including 616 (3.0%) with cirrhosis. Risk factors for significant fibrosis or cirrhosis included male sex, BMI <18, WHO clinical stage 3 or 4, CD4+ count <200 cells/mm(3) , and tuberculosis. Among the 237 (1.2%) who were tested, HBsAg-positive patients had four times the odds (adjusted odds ratio, 4.15; 95% CI, 1.71-10.04) of significant fibrosis compared HBsAg-negatives. Both significant fibrosis (adjusted hazard ratio 1.41, 95% CI, 1.21-1.64) and cirrhosis (adjusted hazard ratio 1.57, 95% CI, 1.31-1.89) were associated with increased all-cause mortality. CONCLUSION Liver fibrosis may be a risk factor for mortality during ART among HIV-infected individuals in Africa. APRI is an inexpensive and potentially useful test for liver fibrosis in resource-constrained settings. This article is protected by copyright. All rights reserved.

Chronic hepatitis B virus coinfection is associated with renal impairment among Zambian HIV-infected adults.

Among 6789 HIV-infected Zambian adults screened for hepatitis B virus (HBV) coinfection, estimated glomerular filtration rate (eGFR) was 50-90 mL/minute/1.73 m(2) in 17.6% and <50 mL/minute/1.73 m(2) in 2.5%. Human immunodeficiency virus/HBV coinfection was associated with eGFR <50 mL/minute/1.73 m(2) (adjusted odds ratio, 1.96 [95% confidence interval, 1.34-2.86]), adjusted for age, sex, CD4(+) count, and World Health Organization disease stage.

Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses.

Abacavir hypersensitivity is a severe hypersensitivity reaction which occurs exclusively in carriers of the HLA-B*57∶01 allele. In vitro culture of PBMC with abacavir results in the outgrowth of abacavir-reacting CD8+ T cells, which release IFNγ and are cytotoxic. How this immune response is induced and what is recognized by these T cells is still a matter of debate. We analyzed the conditions required to develop an abacavir-dependent T cell response in vitro. The abacavir reactivity was independent of co-stimulatory signals, as neither DC maturation nor release of inflammatory cytokines were observed upon abacavir exposure. Abacavir induced T cells arose in the absence of professional APC and stemmed from naïve and memory compartments. These features are reminiscent of allo-reactivity. Screening for allo-reactivity revealed that about 5% of generated T cell clones (n = 136) from three donors were allo-reactive exclusively to the related HLA-B*58∶01. The addition of peptides which can bind to the HLA-B*57∶01-abacavir complex and to HLA-B*58∶01 during the induction phase increased the proportion of HLA-B*58∶01 allo-reactive T cell clones from 5% to 42%. In conclusion, abacavir can alter the HLA-B*57∶01-peptide complex in a way that mimics an allo-allele ('altered self-allele') and create the potential for robust T cell responses.

Discorso funebre detto nelle solenni esequie di S.M. Ferdinando Massimiliano imperatore del Messico celebrate dalla comunità israelitica di Trieste nel suo Tempio maggiore la sera del 15 luglio 1867

Marco Tedeschi

Interaction of small molecules with specific immune receptors: the p-i concept and its consequences

Drugs may stimulate the immune system by forming stable new antigenic complexes consisting of the drug or drug metabolite which is covalently bound to a protein or peptide (hapten-carrier complex). Both, B- and T-cell immunity may arise, the latter directed to hapten modified peptides presented by HLA molecules. Beside this immunological stimulation, drugs can also stimulate the immune system through binding by non-covalent bonds to proteins like immune receptors. This so-called “pharmacological interaction with immune receptors” concept (“p-i concept”) may occur with HLA or TCR molecules themselves (p-i HLA or p-i TCR), and not the immunogenic peptide. It is a type of “off-target” activity of the drug on immune receptors, but more complex as various cell types, cell interactions and functionally different T cells are involved. In this review the conditions which lead to activation of T cells by p-i are discussed: important factors for a functional consequence of drug binding is the location of binding (p-i HLA or p-i TCR); the exact site within these immune receptors; the affinity of binding and the finding that p-i HLA can stimulate the immune system like an allo-allele. The p-i concept is able to solve some puzzles of drug hypersensitivity reactions and are a basis to better treat and potentially avoid drug hypersensitivity reactions. Moreover, the p-i concept shows that in contrast to previous beliefs small molecules do interact with immune receptors with functional consequence. But these interactions are not based on “immune recognition”, are at odds with some immunological concepts, but may nevertheless open new possibilities to understand and even treat immune reactions

The emergence of epitheliocystis in the upper Rhone region: evidence for Chlamydiae in wild and farm salmonid populations

We present the first study comparing epitheliocystis in a wild and farmed salmonid in Europe. Sampling three tributaries to the Lake Geneva, including one from headwaters to river mouth, revealed an unequal distribution of epitheliocystis in brown trout (Salmo trutta). When evaluated histologically and comparing sites grouped as wild versus farm, the probability of finding infected trout is higher on farms. In contrast, the infection intensities, as estimated by the number of cysts per gill arch, were higher on average and showed maximum values in the wild trout. Sequence analysis showed the most common epitheliocystis agents were Candidatus Piscichlamydia salmonis, all clustering into a single clade, whereas Candidatus Clavichlamydia salmonicola sequences cluster in two closely related sub-species, of which one was mostly found in farmed fish and the other exclusively in wild brown trout, indicating that farms are unlikely to be the source of infections in wild trout. A detailed morphological analysis of cysts using transmission electron microscopy revealed unique features illustrating the wide divergence existing between Ca. P. salmonis and Ca. C. salmonicola within the phylum Chlamydiae

Hepatitis B Infection, Viral Load and Resistance in HIV-Infected Patients in Mozambique and Zambia.

BACKGROUND Few data on the virological determinants of hepatitis B virus (HBV) infection are available from southern Africa. METHODS We enrolled consecutive HIV-infected adult patients initiating antiretroviral therapy (ART) at two urban clinics in Zambia and four rural clinics in Northern Mozambique between May 2013 and August 2014. HBsAg screening was performed using the Determine® rapid test. Quantitative real-time PCR and HBV sequencing were performed in HBsAg-positive patients. Risk factors for HBV infection were evaluated using Chi-square and Mann-Whitney tests and associations between baseline characteristics and high level HBV replication explored in multivariable logistic regression. RESULTS Seventy-eight of 1,032 participants in Mozambique (7.6%, 95% confidence interval [CI]: 6.1-9.3) and 90 of 797 in Zambia (11.3%, 95% CI: 9.3-13.4) were HBsAg-positive. HBsAg-positive individuals were less likely to be female compared to HBsAg-negative ones (52.3% vs. 66.1%, p<0.001). Among 156 (92.9%) HBsAg-positive patients with an available measurement, median HBV viral load was 13,645 IU/mL (interquartile range: 192-8,617,488 IU/mL) and 77 (49.4%) had high values (>20,000 UI/mL). HBsAg-positive individuals had higher levels of ALT and AST compared to HBsAg-negative ones (both p<0.001). In multivariable analyses, male sex (adjusted odds ratio: 2.59, 95% CI: 1.22-5.53) and CD4 cell count below 200/μl (2.58, 1.20-5.54) were associated with high HBV DNA. HBV genotypes A1 (58.8%) and E (38.2%) were most prevalent. Four patients had probable resistance to lamivudine and/or entecavir. CONCLUSION One half of HBsAg-positive patients demonstrated high HBV viremia, supporting the early initiation of tenofovir-containing ART in HIV/HBV-coinfected adults.

Absence of Active Hepatitis C Virus Infection in Human Immunodeficiency Virus Clinics in Zambia and Mozambique.

Few studies have evaluated the prevalence of replicating hepatitis C virus (HCV) infection in sub-Saharan Africa. Among 1812 individuals infected with human immunodeficiency virus, no patient in rural Mozambique and 4 patients in urban Zambia were positive for anti-HCV antibodies. Of these, none had confirmed HCV replication.

Poetry Chapbook: Red Light Laughter

"Red Light Laughter" is a poetry chapbook containing 20 poems written and edited extensively by Marcus Lloyd Rummell. The poetry included ranges from as recent as April 2010 to as late as January 2009. The book also contains notes, for reference when necessary, and was professionally designed by Lindsey Voskowsky, who is currently employed at the Yale Center of Design.

Na 1 Nachlass Max Horkheimer, 16 - Korrespondenzen u.a. mit Gerhart Jacoby Gordon (p. I 8, 202-379)

2 Briefe von A. Gandon an Max Horkheimer, Februrar 1936; 1 Brief von Max Horkheimer an Lloyd K. Garrison, 25.03.1941; 4 Briefe zwischen Moritz Geiger und Max Horkheimer, 01.12.1935, 1935; 1 Lebenslauf von Alvin Johnsson an Friedrich Pollock; 1 Brief von Alvon Johnson an Friedrich Pollock, 39.09.1940; 1 Brief von Max Horkheimer an Harald Genssler, 04.09.1949; 1 Brief von der George Washington University Washington an Max Horkheimer, 01.03.1939; 2 Briefe von Wolfgang Gerloff an Max Horkheimer, 1934, 1939; 2 Briefe zwsichen Hans Gerth und Max Horkheimer, 28.10.1937, 16.11.1937; 1 Brief von M. Getzer anMax Horkheimer, 04.05.1934; 12 Briefe zwsichen Edgar V. M. Gilbert und Max Horkheimer, 1935-1940; 1 Brief von der Gillespie, Kinsports & Bears Travel Agency New York an Max Horkheimer, 16.04.1935; 1 Entwurf von Max Horkheimer an Morris Ginsberg, Dezember 1935; 19 Briefe zwsichen Morris Ginsberg, Ethel Ginsberg und Max Horkheimer, 1935-1938; 2 Briefe zwischen Robert Morrison MacIver und Max Horkheimer, 18.08.1937, 16.08.1937; 1 Brief von H. Girsberger an Max Horkheimer, 17.08.1938; 1 Brief von Max Horkheimer an Glass, 24.12.1940; 1 Brief von der Glidden Buick Corporation New York an Max Horkheimer, 05.06.1940; 1 Heiratsanzeige von Vera Gold; 4 Briefe zwischen Oskar Goldberg und Max Horkheimer, 1941, 27.08.1941; 10 Briefe zwischen Hans Goldmann und Max Horkheimer, 1934-1937; 14 Briefe zwischen Alfons Goldschmidt und Max Horkheimer, 1936-1938; 7 Briefe zwsichen dem Greater New York Coordinating Committee for German Refugees, New York und Max Horkheimer, 1937-1939; 1 Brief von Max Horkheimer an Simon Guggenheim, 24.01.1938; 3 Briefe zwischen Aron Goldschmidt und Max Horkheimer, 02.02.1939, Mai 1942; 2 Briefe zwischen Berta Goldschmidt und Max Horkheimer, 14.01.1941, 25.02.1941; 4 Briefe von Emma Goldschmidt an Juliette Favez, 1938-1940; 5 Briefe zwischen Emma Goldschmidt und Max Horkheimer, 1938-1940; 2 Briefe zwischen Ernst L. Goldschmidt und Max Horkheimer, 08.07.1937, 18.06.1937; 1 Brief von Thea Goldschmidt an Max Horkheimer, 16.04.1935; 14 Briefe zwischen Kurt Goldstein und Max Horkheimer, 1934-1941; 19 Briefe zwsichen Gerhart Jacoby Gordon und Max Horkheimer, 1934-1937;

Na 1 Nachlass Max Horkheimer, 493 - Korrespondenzen mit Mitarbeitern (u.a. Gerhard Brand, Ludwig von Friedeburg und Jürgen Habermas) aus dem Institut für Sozialforschung (p. V 193, 1 - 212)

Briefe zwischen Mitarbeitern des Instituts für Sozialforschung und Max Horkheimer, 1964-1973; 13 Briefe und Beilagen zwischen dem Verwaltungsleiter IfS Siegfried Geissler und Max Horkheimer, 1968-1973; 9 Briefe zwischen Klaus Körber (Institut für Sozialforschung) und Max Horkheimer, 1971-1973; 2 Briefe zwischen dem Professor Rudolf Gunzert und Max Horkheimer, 1972; 2 Briefe zwischen Dr. Joachim Bergmann (Institut für Sozialforschung) und Max Horkheimer, 1971; 2 Briefe zwischen dem Professor Gerhard Brandt und Max Horkheimer, 1971; 6 Briefe zwischen Herbert Ludwig (Institut für Sozialforschung) und Max Horkheimer, 1966-1967; 3 Briefe von Max Horkheimer an Professor Franz Böhm, 1966; Briefe zwischen den Mitarbeitern des Instituts für Sozialforschung und Max Horkheimer, 1955-1959; 4 Briefe von Jürgen Habermas an Max Horkheimer, Frankfurt, 1957-1959; 3 Briefe zwischen Christoph Oehler und Max Horkheimer, 1959; 13 Briefe zwischen Ludwig von Friedeburg und Max Horkheimer, 1955-1959; 1 Brief von Werner Wilkening an Max Horkheimer, 1958; 1 Brief von Gerhard Brandt an Max Horkheimer, 1958; 1 Brief von Max Horkheimer an den Dekan Helmut Viebrock, 1958; 2 Briefe von Egon Becker mit Helge Pross und Ludwig Friedeburg an Max Horkheimer, Frankfurt, 1958-1959; 2 Briefe von Helge Pross mit Egon Becker und Ludwig Friedeburg an Max Horkheimer, Frankfurt, 1958-1959; 1 Brief von Dieter Arenz an Max Horkheimer, Frankfurt, 1956; Briefe vom und an das Institut für Sozialforschung (Advisory Board of the Institute of Social Research), 1940-1947; Briefe und Briefentwürfe an und von Mitgliedern des Advisory Board betreffend die Zusendung von Max Horkheimer "Eclipse of Reason" und Karl August Wittvogel/Olga Lang, "Chinese Family and Society"; vom Institut für Sozialforschung, 1946-1947; 1 Brief von Edwin Borchard vom Institut für Sozialforschung, 1947; 1 Brief von Friedrich Pollock an Alfred E. Cohn, Los Angeles, 1947; 1 Brief von Friedrich Pollock an Stephan Duggan, Los Angeles, 1947; 2 Briefe zwischen Lloyd K. Garrison und Friedrich. Pollock, 1947; 1 Brief von Friedrich Pollock an Calvin B. Hoover, Los Angeles, 1947; 1 Brief von Friedrich Pollock an Philip C. Jessup, Los Angeles, 1947; 1 Brief von Friedrich Pollock an Wesley C. Mitchell, Los Angeles, 1947; 1 Brief von Friedrich Pollock an William A. Neilson, Los Angeles, 1947; 1 Brief von Friedrich Pollock an Frederick M. Padelford, Los Angeles, 1947; 1 Brief von Friedrich Pollock an Thorsten Sellin, Los Angeles, 1947; 3 Briefe zwischen John Whyte und Friedrich Pollock, 1947; 2 Briefe zwischen Louis Wirth und Friedrich Pollock, 1947; 1 Brief von Friedrich Pollock an Howard Woolston, Los Angeles, 1947; 1 Brief von George H. Sabine an das Institut für Sozialforschung, Ithaca, New York, 1946; Briefe und Briefentwürfe an und von Mitgliedern des Advisory Board betreffend den Druck eines neuen Briefkopfs des Instituts, 1940; 1 Brief von Leo Löwenthal, Pacific Palisades an Margot von Mendelssohn, 1942; 1 Brief von Leo Löwenthal an Margot von Mendelssohn, Pacific Palisades, 1942; 1 Brief von Max Horkheimer an K. Pilser, 1942; 2 Briefe zwischen Charles A. Beard und Max Horkheimer, 1940; 2 Briefe zwischen Edwin M. Borchard und Max Horkheimer, 1940; 3 Briefe zwischen Henry Sloane Coffin und Max Horkheimer, 1940; 2 Briefe zwischen Morris R. Cohen und Max Horkheimer, 1940; 2 Briefe zwischen Alfred E. Cohn und Max Horkheimer, 1940; 2 Briefe zwischen Stephen Duggan und Max Horkheimer, 1940; 2 Briefe zwischen dem Soziologen Henry Pratt Fairchild und Max Horkheimer, 1940; 2 Briefe zwischen Sidney B. Fay und Max Horkheimer, 1940; 2 Briefe zwischen Lloyd K. Garrison und Max Horkheimer, 1940; 1 Brief von Max Horkheimer an Calvin B. Hoover, 1940; 2 Briefe zwischen Robert M. Hutchins und Max Horkheimer, 1940; 2 Briefe zwischen Philip C. Jessup und Max Horkheimer, 1940; 2 Briefe zwischen Lewis L. Lorwin und Max Horkheimer, 1940; 2 Briefe zwischen Robert S. Lynd und Max Horkheimer, 1940; 2 Briefe zwischen Robert M. MacIver und Max Horkheimer, 1940; 2 Briefe von Max Horkheimer an Charles H. McIlwain, 1940; 2 Briefe zwischen Charles E. Merriam und Max Horkheimer, 1940; 2 Briefe zwischen Wesley C. Mitchell und Max Horkheimer, 1940; 2 Briefe zwischen William A. Nielson und Max Horkheimer, 1940; 5 Briefe zwischen Howard W. Odum und Max Horkheimer, 1940; 3 Briefe zwischen Frederick M. Padelford und Max Horkheimer, 1940; 3 Briefe von Max Horkheimer an Max Radin, 1940; 2 Briefe zwischen George H. Sabine und Max Horkheimer, 1940; 2 Briefe zwischen Thorsten Sellin und Max Horkheimer, 1940; 2 Briefe zwischen James T. Shotwell und Max Horkheimer, 1940; 1 Brief von dem Soziologen Louis Wirth an Franz Neumann, Chicago, 1940; 1 Brief von Louis Wirth an Franz L. Neumann, Chicago, 1940; 3 Briefe zwischen Howard Woolston und Max Horkheimer, 1940;

Na 1 Nachlass Max Horkheimer, 668 - Memoranden und Briefe zur Antisemitismus-Forschung (p. IX 120a)

Memoranden und Briefe zur Antisemitismus-Forschung (Juni 1944 - Februar 1945): 1. Harold Schiff, Anti-Defamation Leage of B'nai B'rith: Memorandum: "Book and Literature Distribution Assignement No. 4" (14.2.1945), als Typoskript vervielfältigt, 3 Blatt; 2. "Memorandum on Program for the Commission on Antisemitism of the American Jewish Congress" (7.11.1944), Typoskript, 11 Blatt mit eigenhändigen Notizen von Paul W. Massing und Friedrich Pollock, 2 Blatt; 3. Joint Defense Appeal of the American Jewish Committee and Anti-Defamation Leage of B'nai B'rith: 1 Brief mit Unterschrift an Friedrich Pollock, New York, 4.12.1944; 4. Toni Stulper: 1 Brief mit Unterschrift an Friedrich Pollock, New York, 14.6.1944; 5. W. Lloyd Warner: 1 Brief (Abschrift) an Philip (?) Klein, Chicago, 9.6.1944; 6. Friedrich Pollock: eigenhändige Notiz zur "Anti-Anti-Propaganda", 1 Blatt;

Na 1 Nachlass Max Horkheimer, 699 - Cultural Aspects of National Socialism. A Research Project (p. IX 170.15-17a - IX 170.19)

Neumann, Franz: Memorandum über Gespräche mit Harold Lasswell. 30.03.1941, Typoskript mit handschriftlichen Korekturen, 4 Blatt; Neumann, Franz: Memorandum über Gespräche mit Goodvin Watson. 21.05.1941, Typoskript, 2 Blatt; [Anderson, Eugene N.:] "Professor Anderson's Notes and criticisms to the project of German society and culture". Typoskript, 7 Blatt; "Budget for the proposed Research Project of Cultural Aspects of National Socialism". Handschriftliche Notizen, 1 Blatt; Institut of Social Research: Brief an Rockefeller Foundation, New York, 24.06.1941 verschiedene Typoskripte, zum Teil mit handschriftlichen Korrekturen, circa 35 Blatt; ein Manuskript, 6 Blatt; ein Entwurf, Typoskript, 1 Blatt; Adorno, Theodor W.: 2 Briefe an I. Berlin, ohne Ort, 1940-1941; Empfehlungsschreiben zur Unterstützung des Projekts, von: Lutz, Ralph H.: 1 Brief (Abschrift) an Frederick Pollock, 11.07.1941; MacIver, Robert M.: 1 Brief (Abschrift): an New York Foundation, ohne Ort, 07.07.1941; Shotwell, James T.: 1 Brief (Abschrift) an Frederick Pollock, Woodstock, 08.07.1941; Radin, MAx: 1 Brief (Abschrift) an New York Foundation, [Los Angeles], 08.07-1941; 5 Blatt; Antwortbriefe an das Institut bzw. Max Horkheimer aufgrund der Zusendung des Umrisses des Forschungsprojektes, von: Lorwin, Lewis L.; Wooleton, H.; O'Quin, Patricia, Odum, Howard W.; Fay, Sidney B.; Merriam, Charles E.; Hoover, Calvin B.; Garrison, Lloyd K.; März bis Mai 1941, 8 Blatt;