Verteporfin therapy in occult with no classic CNV due to AMD: results of the Photodynamic Therapy in Occult-Only Lesions study

PURPOSE: To provide further information on verteporfin photodynamic therapy in occult with no classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). METHODS: Verteporfin therapy was administered at baseline and then at months 3, 6, and 9, if fluorescein leakage from CNV was evident on angiography. RESULTS: Of 202 patients enrolled, 184 completed 12 months. Each patient was treated in one eye only. All study eyes received verteporfin therapy at baseline, with a progressive decrease in the number treated at subsequent visits (mean 2.5 treatments during 12 months). The mean change in visual acuity letter score from baseline to month 12 was -11.9. At month 12, 164 eyes (82.4%) had lost <30 letters of visual acuity, 123 eyes (61.8%) had lost <15 letters, 78 eyes (39.2%) had lost <5 letters, 31 (15.6%) had >5-letter increase, and 7 (3.5%) had >15-letter improvement. The percentage of eyes with fluorescein leakage from CNV decreased from 75.5% at month 3 to 25.1% at month 12. Adverse events were documented for 54% patients. Few patients had treatment-associated adverse events (7%). Acute severe visual acuity decrease occurred in two eyes (1%), one of which had visual acuity that returned to baseline by the next follow-up visit. CONCLUSIONS: This study provides additional evidence that over 12 months, verteporfin is generally well tolerated and maintains or improves visual acuity in over one-third of eyes containing occult-only CNV. Verteporfin also improved anatomical outcomes by reducing leakage from CNV in at least two-thirds of eyes.

Polarization properties of polymer-based photonic crystal fibers

Selectively filled photonic crystal fibers with polydimethylsiloxane (PDMS), a silicon-type material, have been studied. Is has been demonstrated that polarization properties of these hybrid devices and the properties of the guided light in relation with the temperature changes, finding that the state of polarization (SOP) change with the increasing temperature but remains constant for a wide spectrum of wavelengths for a determinate temperature.

Commonplace book of Hector Orr, 1789-1804

Hector Orr began recording entries in this commonplace book during his first year as a student at Harvard and continued writing in the volume sporadically until 1804. The entries written while he was a student, from 1789 to 1792, include themes written on the following topics: Time, Discontent, Patriotism, Virtue, Conscience, Patience, Avarice, Compassion, Mortality, Self-knowledge, Benevolence, Morning, Anger, Profanity, Bribery, Autumn and Winter, Hermitage, Conscience and Anticipation. He also wrote detailed entries about the forensic disputations in which he and his classmates participated, explaining both the affirmative and negative positions. One of these disputations involved discussion of the Stamp Act, which was then quite recent history. Orr's entries about the disputations list the names of students involved and specify their position in the argument.

The works of Matthew Arnold.

"This edition consists of seven hundred and seventy-five copies."

The discovery and conquest of Mexico, 1517-1521.

"Some extracts from the letters of Hernando Cortés are added to make clear the topography of the siege of the city."

Martine's hand-book of etiquette and guide to true politeness : a complete manual for those who desire to understand the rules of good breeding, the customs of good society, and to avoid incorrect and vulgar habits : containing clear and comprehensive directions for correct manners, dress, and conversation, instructions for good behavior at dinner parties and the table : together with the etiquette of the ball and assembly room, evening parties, deportment in the street and when traveling, and the usage to be observed when visiting or receiving calls : to which is added the etiquette of courtship, marriage, domestic duties, and fifty-six rules to be observed in general society /

"Almost every gentleman has wine at his table whenever he has invited guests"-- p. [74].

The contest over the ratification of the Federal Constitution in the State of Massachusetts.

Appendices: A. Letter of "Cornelius". B. Letters of "A Republican federalist". C. Bibliographical note. D. List of authorities cited (p. 180-184)

Foreign commerce and navigation of the United States ...

The statistics of "Immigration and passenger movement" are included in the report on foreign commerce to 1895, and for 1893-1894 are also published separately.

Review of report on Little Nemaha River and tributaries, Nebraska.

Letters of transmittal inserted.

Works of Henry, lord Brougham ...

[v. 1] Lives of philosophers of the time of George III. 1855.--[v. 2] Lives of men of letters of the time of George III. 1855.--[v. 3]-5. Historical sketches of statesmen who flourished in the time of George III. 1856-58.--v. 6. Natural theology ... 1856.--v. 7. Rhetorical and literary dissertations and addresses. 1856.--v. 8. Historical and political dissertations. 1857.--v. 9-10. Speeches on social and political subjects. 1857.--v. 11. The British constitution: its history, structure, and working. 1861.

The Elector's guide. Addressed to the freeholders of the county of York.

No. I. The "Catholic question".--No. II. The general state of the country banks and paper money; Death of Alexander, emperor of Russia; State of parties in the kingdom; A letter to Fountayne Wilson, esq.; Duncombe and the treadmill; Poetry and miscellanies.--No. III. A letter to the Duke of York; Auri sacra fames; or, Sturdy beggars: a county job; Church Methodism; A Protestant confessor; His Majesty's speech to Parliament; Miscellanies, and poetry.--No. IV. A letter to Daniel Sykes, esq. on West Indian slavery; Catholic and Protestant; The last man; Confidence in banks; Hints to electors; The proceedings in Parliament, &c., &c., &c.--No. V. An address to the suffering people of England; Slavery; A letter to Sir John Bayley, knt,; Banks; The Protestant champion; Poetry, &c., &c.--No. VI. A charge of His Grace the Archbishop of York to the clergy of the diocese; A secret; A good action.--No. VII. Observations upon county representation; A full account of the county meeting, &c., &c.

The heart of Gambetta,

"The letters of Madame Léonie Léon": p. 237-253.

Slaveholding and colonization : a reply to George D. Armstrong, D.D., of Norfolk, Va., on slaveholding and colonization.

"Reprinted from the Presbyterian Magazine, of December, 1858. It is the fifth of a series of Replies ... in answer to the Letters of Dr. Armstrong."

The manuscripts of Henry Duncan Skrine, esq. Salvetti correspondence.

Letters of Amerigo Salvetti, Tuscan representative at the British court, to the Grand Duke of Tuscany. These letters, written from April, 1625, to December, 1628, were in Tuscan dialect and partly in cipher: the translation was made by H. Wilson of Florence. cf. p.[1]

Foreign commerce and navigation of the United States.

The statistics of "Immigration and passenger movement" are included in the report on foreign commerce to 1895, and for 1893-1894 are also published separately.