Simultaneous irradiation of fibroblasts and carcinoma cells repress the secretion of soluble factors able to stimulate carcinoma cell migration.

Stroma mediated wound healing signals may share similarities with the ones produced by tumor's microenvironment and their modulation may impact tumor response to the various anti-cancer treatments including radiation therapy. Therefore we conducted this study, to assess the crosstalk between stromal and carcinoma cells in response to radiotherapy by genetic modulation of the stroma and irradiation. We found that fibroblasts irrespective of their RhoB status do not modulate intrinsic radiosensitivity of TC-1 but produce diffusible factors able to modify tumor cell fate. Then we found that Wt and RhoB deficient fibroblasts stimulated TC-1 migration through distinct mechanisms which are TGF-β1 and MMP-mediated respectively. Lastly, we found that simultaneous irradiation of fibroblasts and TC-1 abrogated the pro-migratory phenotype by repression of TGF-β and MMP secretion. This last result is highly relevant to the clinical situation and suggests that conversely to, the current view; irradiated stroma would not enhance carcinoma migration and could be manipulated to promote anti-tumor immune response.

Optimizing the Testing Process in Module Testing – Functional Testing Interface

Today's business environment has become increasingly unexpected and fast changing because of the global competition. This new environment requires the companies to organize their control differently, e.g. by logistic process thinking. Logistic process thinking in software engineering applies the principles of production process to immaterial products. Processes must be optimized, so that every phase adds value to the customer, and the lead times can be cut shorter to meet the new customer requirements. The purpose of this thesis is to examine and optimize the testing processes of software engineering concentrating on module testing, functional testing and their interface. The concept of logistic process thinking is introduced through production process, value added model and process management. Also theory of testing based on literature is presented, concentrating on module testing and functional testing. The testing processes of the Case Company are presented together with the project models in which they are implemented. The real life practices in module testing and functional testing and their interface are examined through interviews. These practices are analyzed against the processes and the testing theory, through which ideas for optimizing the testing process are introduced. The project world of the Case Company is also introduced together with two example testing projects in different life cycle phases. The examples give a view of how much effort of the project is put in different types of testing.

Portable Application User Interface Development in Symbian OS

Symbian OS on käyttöjärjestelmä edistyneille matkapuhelimille. Symbiania käyttävistä laitteista on monia muunnoksia. Joitakin käytetään näppäimistön avulla ja toisia kynällä. Näytön mittasuhteet ja muut ominaisuudet vaihtelevat huomattavasti älypuhelimista kommunikaattoreihin. Tämän seurauksena Symbianin eri laiteperheiden viitemallien käyttöliittymäosat ovat sovelluskehittäjän kannalta melko erilaisia. Esimerkiksi kaikki käyttöliittymäkomponentit eivät ole saatavilla kaikissa laiteperheissä. Perinteisesti sovellusten käyttöliittymät on kirjoitettu erikseen kullekin laiteperheelle, mikä pidentää kehitysaikaa. Tämä työ esittelee Symbianin käyttöliittymäarkkitehtuurin, siirrettävyyden käsitteen ja tekniikoita sovellusten suunnitteluun ja toteutukseen, joilla saavutetaan parempi siirrettävyys Symbian-ympäristössä. Työssä suunnitellaan ja toteutetaan AppTest-nimisen testaustyökalun käyttöliittymä siten, että sovellus on helposti siirrettävissä eri laiteperheisiin.