Adrenocorticotropin stimulation tests in patients with hypothalamic-pituitary disease: low dose, standard high dose and 8-h infusion tests

Objectives Low doses of ACTH [1-24] (0.1, 0.5 and 1.0 mug per 1.73 m(2)) may provide a more physiological level of adrenal stimulation than the standard 250 mug test, but not all studies have concluded that the 1.0 fig is a more sensitive screening test for central hypoadrenalism. Eight-hour infusions of high dose ACTH [1-24] have also been suggested as a means of assessing the adrenals' capacity for sustained cortisol secretion. In this study, we compared the diagnostic accuracy of three low dose ACTH tests (LDTs) and the 8-h infusion with the standard 250 jig test (HDT) and the insulin hypoglycaemia test (IHT) in patients with hypothalamic-pituitary disease. Subjects and design Three groups of subjects were studied. A healthy control group (group 1, n=9) and 33 patients with known hypothalamic or pituitary disease who were divided into group 2 (n=12, underwent IHT) and group 3 (n=21, IHT contraindicated). Six different tests were performed: a standard IHT (0.15 U/kg soluble insulin); a 60-minute 250 mug HDT; three different LDTs using 0.1 mug, 0.5 mug and 1.0 mug (all per 1.73 m(2)); and an 8-h infusion test (250 mug ACTH [1-24] at a constant rate over 8 h). Results Nine out of the 12 patients in group 2 failed the IHT. Three out of 12 patients from group 2 who clearly passed the IHT, also passed all the ACTH [1-24] stimulation tests. Seven of the 9 patients who failed the lHT, failed by a clear margin (peak cortisol

Assessing ecological impacts of shrimp and sewage effluent: Biological indicators with standard water quality analyses

Despite evidence linking shrimp farming to several cases of environmental degradation, there remains a lack of ecologically meaningful information about the impacts of effluent on receiving waters. The aim of this study was to determine the biological impact of shrimp farm effluent, and to compare and distinguish its impacts from treated sewage effluent. Analyses included standard water quality/sediment parameters, as well as biological indicators including tissue nitrogen (N) content, stable isotope ratio of nitrogen (delta N-15) and amino acid composition of inhabitant seagrasses, mangroves and macroalgae. The study area consisted of two tidal creeks, one receiving effluent from a sewage treatment plant and the other from an intensive shrimp farm. The creeks discharged into the western side of Moreton Bay, a sub-tropical coastal embayment on the east coast of Australia. Characterization of water quality revealed significant differences between the creeks, and with unimpacted eastern Moreton Bay. The sewage creek had higher concentrations of dissolved nutrients (predominantly NO3-/NO2- and PO43-, compared to NH4+ in the shrimp creek). In contrast, the shrimp creek was more turbid and had higher phytoplankton productivity. Beyond 750 m from the creek mouths, water quality parameters were indistinguishable from eastern Moreton Bay values. Biological indicators detected significant impacts up to 4 km beyond the creek mouths (reference site). Elevated plant delta N-15 values ranged from 10.4-19.6 parts per thousand at the site of sewage discharge to 2.9-4.5 parts per thousand at the reference site. The free amino acid concentration and composition of seagrass and macroalgae was used to distinguish between the uptake of sewage and shrimp derived N. Proline (seagrass) and serine (macroalgae) were high in sewage impacted plants and glutamine (seagrass) and alanine (macroalgae) were high in plants impacted by shrimp effluent. The delta N-15 isotopic signatures and free amino acid composition of inhabitant flora indicated that sewage N extended further from the creek mouths than shrimp N. The combination of physical/chemical and biological indicators used in this study was effective in distinguishing the composition and subsequent impacts of aquaculture and sewage effluent on the receiving waters. (C) 2001 Academic Press.

On the nonlocality of the quantum channel in the standard teleportation protocol

By exhibiting a violation of a novel form of the Bell-CHSH inequality, Żukowski has recently established that the quantum correlations exploited in the standard perfect teleportation protocol cannot be recovered by any local hidden variables model. In the case of imperfect teleportation, we show that a violation of a generalized form of Żukowski's teleportation inequality can only occur if the channel state, considered by itself, already violates a Bell-CHSH inequality. On the other hand, the fact that the channel state violates a Bell-CHSH inequality is not sufficient to imply a violation of Żukowski's teleportation inequality (or any of its generalizations). The implication does hold, however, if the fidelity of the teleportation exceeds ≈ 0.90. © 2001 Elsevier Science B.V. All rights reserved.

An automated multi-unit composting facility for biodegradability evaluations

A system has been developed for studying the biodegradation of natural and synthetic polymeric material. The system is based on standard methods developed by the European Committee for Standardisation (CEN TC 261) (ISO/DIS 14855) and the American Society of Testing Materials, 'ASTM. Standard Test Method for Determining Aerobic. Biodegradation of Plastic Materials under Controlled Composting Conditions' (ASTM D 5338-92). A new low-cost compost facility has been used which satisfies the requirements of these standards. The system has been automated for data collection and has been run under the conditions specified by the standards. In the system, cellulose, newspaper and two starch-based polymers were treated with compost in a series of 3dm(3) vessels at 52 degreesC and under conditions of optimum moisture and pH. The degradation was followed over time by measuring the amount of carbon released as carbon dioxide. (C) 2001 Society of Chemical Industry.

A ISO 9000 e outras exigências da maior potência econômica do mundo

Exigências de certificação, normas obrigatórias, selo de conformidade da Comunidade Européia e suas novas regulamentações restritivas sobre sistemas de gerenciamento da qualidade e ambiental.

The undergraduate level (1st study cycle) as a fundamental platform/standard for the development of Urban and Regional Planning in higher education programs

LUDA is a research project of Key Action 4 "City of Tomorrow & Cultural Heritage" of the programme "Energy, Environment and Sustainable Development" within the Fifth Framework Programme of the European Commission

Air fungal contamination in two elementary schools in Lisbon, Portugal

A descriptive study was developed to monitor air fungal contamination in two elementary schools in Lisbon, Portugal. Eight air samples of 250 litres through impaction method were collected in canteen, library, classrooms and also, outside premises as reference place. Simultaneously, were also monitored environmental parameters, including temperature, and humidity through the equipment Babouc, LSI Sistems and according to the International Standard ISO 7726 - 1998. Considering both schools, sixteen different species of fungi in air were identified, being the 2 most commonly isolated Cladosporium sp. (51,1%) and Penicillium sp. (27,5%). Besides these genera Trichoderma, Aspergillus, Alternaria, Chrysonilia, Botritys, Ulocladium, Athrium, Aureobasidium, Phoma, Scedosporium e Geotrichum were also isolated. Regarding yeasts, Candida sp., Cryptococcus sp. and Rhodotorula sp. were isolated. The youngest school, as well canteens in each school, presented the worst results concerning the air fungal contamination, maybe due to the higher number of occupants. There was no significant relationship (p>0,05) between fungal contamination and temperature and humidity.

Formaldeído em habitações domésticas: contaminação ambiental e potenciais fontes

Do ponto de vista das preocupações de saúde, os níveis de contaminação do ar interior assumem actualmente uma elevada importância quando se tem em consideração que as pessoas passam a maior parte do seu tempo no interior de edifícios. Neste contexto, o formaldeído é um dos poluentes mais preocupantes e, inclusivamente, os resultados de concentração obtidos em habitações do espaço Europeu foram considerados preocupantes devido ao facto de estarem relacionados com efeitos negativos para a saúde. O estudo exploratório desenvolvido pretendeu disponibilizar informação acerca das concentrações de formaldeído existentes em habitações domésticas portuguesas. Estudou‑se a presença de formaldeído em habitações novas e habitações domésticas com ocupação, abrangendo 6 unidades de cada um dos tipos considerados. Para a avaliação ambiental foi utilizado um equipamento de leitura direta que deteta as concentrações de formaldeído por fotoionização com uma lâmpada de 11,7 eV. A temperatura ambiente e a humidade relativa foram igualmente medidas, de acordo com o estipulado na Norma Internacional ISO 7726:1998. No caso das habitações novas foram registados valores de concentração superiores a 0,08 ppm em 3 das unidades estudadas. Por outro lado, em 4 das habitações com ocupação foram obtidos valores superiores a 0,08 ppm. O desenvolvimento deste estudo permitiu reconhecer algumas das possíveis fontes emissoras e os factores que influenciam as concentrações de formaldeído nas habitações em Portugal. ABSTRACT - Nowadays, indoor air contamination is considering an important health issue considering that people spend most of their time indoors. In this context, formaldehyde is a pollutant of major concern and, recently, concentration results obtained in European dwellings reveal high concentrations and values related with negative health effects in occupants. The present exploratory study sought to provide information about formaldehyde concentrations in Portuguese dwellings. It was studied formaldehyde presence in new dwellings and dwellings with occupation and included 6 units of each setting. For concentrations measure, it was used a direct‑reading equipment that detects formaldehyde concentration by photoionization. Temperature and relative humidity were also measured in accordance with International Standard ISO 7726:1998. In the case of new dwellings, in 3 units concentration values were higher than 0.08 ppm. In addition, in 4 units of the 6 dwellings with occupation, concentrations higher than this reference value were obtained. The development of this study permitted to recognize some of the possible indoors emissions sources and to define several of the preventive measures that can be applied.

Air fungal contamination in ten hospitals’ food units from Lisbon

A descriptive study was developed to monitor air fungal contamination in ten food units from hospitals. Fifty air samples of 250 litres were collected through impaction method. Samples were collected in food storage facilities, kitchen, food plating, canteen and also, outside premises, since this is the place regarded as reference. Simultaneously, environmental parameters were also monitored, including temperature and relative humidity through the equipment Babouc, LSI Sistems and according to the International Standard ISO 7726.

Concepção da implementação de um sistema de gestão ambiental e estudo da sua integração com o sistema de gestão da qualidade numa metalomecânica

A protecção do meio ambiente e a promoção de um desenvolvimento sustentável têm assumido um papel de crescente importância junto das organizações que, conscientes das suas fragilidades e pressionadas pela opinião pública, têm adoptado sistemas voluntários de acção ambiental. O presente trabalho tem como principal objectivo desenvolver um projecto de planeamento de gestão ambiental tendo por base a norma NP EN ISSO 14001:2004, possibilitando o desenvolvimento e a implementação de um Sistema de Gestão Ambiental numa indústria metalomecânica, para potencial integração com o actual Sistema de Gestão da Qualidade e posterior certificação. Nesse sentido realizou-se uma revisão bibliográfica aos principais conceitos relacionados com o sistema de gestão ambiental, para permitir um melhor entendimento dos requisitos necessários para a concepção do SGA. Posteriormente procedeu-se ao enquadramento da organização face à NP EN ISSO 14001:2004, procedendo-se ao levantamento dos aspectos ambientais da sua actividade e avaliação da sua significância. Foi realizada igualmente a identificação e análise da situação da organização em termos de requisitos legais ambientais. Para os aspectos ambientais significativos foi elaborado o programa de melhoria ambiental, tendo os mesmos sido classificados por prioridades e sempre que aplicável, definiram-se metas e objectivos ou procedimentos de controlo operacional para prevenir, reduzir ou eliminar o respectivo impacte ambiental. Realizou-se ainda um estudo da integração com base na especificação PAS 99:2006 do British Standard Institute, que permitiu concluir que a especificação em si constitui uma boa ferramenta para orientar a integração de sistemas de gestão. Como príncipais benefícios do desenvolvimento e implementação do SGA para a organização, extraimos um controlo eficaz da legislação; uma redução dos impactes ambientais significativos associados às actividades da organização, optimizando os consumos de água e energia e prevenindo a poluição através de uma gestão eficiente no consumo das matérias-pimas e na produção de resíduos. O Sistema Integrado de Gestão de Qualidade e Ambiente em implementação na ARNEG Portuguesa permite atingir benefícios nomeadamente ao nível operacional e burocrático com a integração de procedimentos, processos, estrutura organizacional e responsabilidades.