Gastroprotective effect of Cissus sicyoides (Vitaceae): Involvement of microcirculation, endogenous sulfhydryls and nitric oxide

Aim of the study: Cissus sicyoides L. is a medicinal plant popularly known in Brazil against various diseases and the research interest in this plant is justifiable because of its potential medicinal value in stomachache and gastric ulcer.Materials and methods: The methanolic extract obtained from the leaves of Cissus sicyoides (Cc) was evaluated for the ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3 M HCl/60% EtOH, absolute ethanol, piroxicam and pylorus ligature) in rodents. We also evaluated microcirculation, antioxidant action and participation of NO (nitric oxide) and sulfhydryls (SH) groups in the Cc gastroprotective action.Results: Administration of Cc significantly reduced gastric lesions induced by different ulcerogenic agents in rodents. This extract administered by oral route significantly increased gastric volume without exerting antisecretory effect. The Cc effect involved an increase of the defense mechanism of the gastrointestinal mucosa such as NO and SH groups that prevent and attenuate the ulcer process. The Cc also has antioxidant property against oxidative stress but does not modify microcirculation response in gastric mucosa.Conclusions: These results confirmed the traditional use of Cissus sicyoides for the treatment of gastric ulcer. (C) 2008 Elsevier B.V. All rights reserved.

First observation of the doubly charmed baryon Ξcc +

The first experimental evidence for one of the six predicted baryon states which contain two valence charmed quarks-the doubly charmed baryons. As such, there were many predictions of the masses and other properties of these states. The properties of doubly charmed baryons provide a new window into the structure of baryonic matter.

Retificador trifásico de 18 pulsos com estágio CC controlado por histerese constante

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise e modelação de perdas em conversores CC-CC do tipo Boost entrelaçados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estabilidade, desempenho e observação de estado de sistemas chaveados afins: aplicações aos conversores CC-CC

Pós-graduação em Engenharia Elétrica - FEIS

Projeto de controladores para sistemas chaveados com aplicações em conversores cc-cc

Pós-graduação em Engenharia Elétrica - FEIS

Análise da expressão de genes em gêmeos monozigóticos: impacto da aptidão cardiorrespiratória

Pós-graduação em Ciências da Motricidade - IBRC

Projeto e usinagem do cabeçote para um motor 4 tempos, a gasolina, monocilíndrico de 400 cc e refrigerado a ar

Pós-graduação em Engenharia Mecânica - FEG

Retificador entrelaçado com elevado fator de potência para operação de um veículo trólebus alimentado por redes em CA Ou CC

This paper presents the development and the main results for an interleaved boost rectifier operating as a special input power stage for a trolleybus type vehicle, allowing its feeding by alternate current (AC) or direct current (DC) distribution power systems. When feeding with two wires (single phase) alternate current distribution system, the converter accomplish active power factor correction, providing a relatively sinusoidal current with low total harmonic distortion (THD) and fully complying with IEC 61000-3-4 standards. In addition, a management control system promotes the required automatic operation changes for the proposed rectifier when the vehicle is changing from the DC distribution power system to the AC distribution power system and vice-versa, keeping its original electrical DC system characteristics for the adjustable speed driver sub-system. The main experimental results for a prototype rated at 150kW are presented, considering its application for a trolleybus with DC adjustable speed driver, demonstrating the proposed converter benefits and the possibility of AC feeding system for trolleybus type vehicle.

The Probe, Issue 174 – March 1997

Outwitting Urban Beaver, by C. E. "Ki" Faulkner, Regional Director, Region 0, NADCA Bear Gets Attention in Southeast Chinese disease Threatens Rabbits Product Announcements: BEAR BE GONE™ -- a device designed to deter bears from foraging in trash cans. Booklet: "Using Guard Animals to Protect Livestock" Abstracts Published at the 3rd Annual Conference of The Wildlife Society: A case study of black bear movements and survival after landfill closure in the central Adirondacks, by Ann M. Russell and S.L. Simek Ecology of coyotes in a sheep ranching environment, by Ben N. Sacks, J.C.C. Neale, M. Jaeger, and D. R. McCullough Design and analysis of carnivore scent-station surveys, by Glen Sargeant, Douglas H. Johnson, and William Berg Public attitudes toward wildlife damage management, by Robert H. Schmidt, M.W. Brunson, andD. Reiter Human dimensions of wildlife contraception, by Robert H. Schmidt and D. E. Mclvor Economic assessment of rabies control efforts in Texas, by Randy M. Smith Methyl salicylate: a naturally occurring avian repellent, by Shirley Wager-Page A brief historical perspective on wildlife contraception research, by Robert J. Warren Wildlife-caused losses to agriculture in 1994, by Alice P. Wywialowski

CC chemokine ligand 3 and receptors 1 and 5 gene expression in recurrent aphthous stomatitis

Objective. The aim of this study was to investigate the local and systemic expression of CC-chemokine ligand 3 (CCL3) and its receptors (CCR1 and CCR5) in tissue samples and peripheral blood mononuclear cells of recurrent aphthous stomatitis (RAS) patients. Study Design. This case-control study enrolled 29 patients presenting severe RAS manifestations and 20 non-RAS patients proportionally matched by sex and age. Total RNA was extracted from biopsy specimens and peripheral blood mononuclear cells for quatitative reverse-transcription polymerase chain reaction. The data obtained by relative quantification were evaluated by the 2(-Delta Delta Ct) method, normalized by the expression of an endogenous control, and analyzed by Student t test. Results. The results demonstrated overexpression in RAS tissue samples of all of the chemokines evaluated compared with healthy oral mucosa, whereas the blood samples showed only CCR1 overexpression in RAS patients. Conclusions. These findings suggest that the increased expression of CCL3, CCR1, and CCR5 may influence the immune response in RAS by T(H)1 cytokine polarization. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:93-98)

Pavimentando Roraima: a BR-174 como exemplo das lógicas neoliberais de transnacionalização do território na Amazônia Ocidental

Este artigo discute a pavimentação da BR-174 na metade da década de 1990 e as suas consequências socioespaciais no estado de Roraima. O caso é apresentado como um exemplo da transformação das intervenções territoriais na Amazônia no contexto da neoliberalização do Estado e da produção de um espaço econômico transnacional. Os investimentos federais para o desenvolvimento rodoviário e infraestruturas auxiliares trouxeram conectividade sem precedentes para o estado de Roraima, além de gerar crescimento econômico. Todavia, o artigo argumenta que, além dos novos discursos de desenvolvimento regional sustentável, as lógicas dominantes dos projetos, tais como o melhoramento da BR-174, são as de um neoliberalismo em expansão transnacional, no qual o Estado empreendedor torna-se um parceiro para o estabelecimento de mercados externos mais do que o principal agente da integração do território nacional. Assim, no desenho da BR-174, Roraima aparece, principalmente, como um espaço estratégico de conexão transfronteiriça que liga a Amazônia brasileira aos portos do Caribe. Entretanto, passada mais de uma década desde a conclusão do projeto, a concentração territorial tem se aprofundado ao passo que emergem novas desigualdades socioespaciais intimamente atreladas às funções e fluxos que a integração rodoviária criou.