University of Michigan Men's Tennis Team, 1928

Standing: Ralph Brody, coach Henry Hutchins, Kenneth Schafer, Henry Graham

Seated: Kingsley Moore, Robert Heaney, captain Horace Barton, Durwin Algyer, Ralph Kempner

Delle opere.

Vol. i, Lettere scientifiche ed erudite. [With 'Elogio del Conte L. Magalotti'.] Vol. ii, Saggi di naturali esperienze fatte nell'Accademia del Cimento.

Opere scelte di Alfonso Varano, degli antichi duchi di Camerino.

Includes errata: p. [4], at end.

Verona illustrata, di Scipione Maffei; con giunte, note e correzioni inedite dell' autore.

Ed. by G. Donadelli.

La Mente di Giambattista Vico; aggiuntovi il primo scritto istorico di Vico.

Mode of access: Internet.

Dante e la filosofia cattolica nel tredicesimo secolo /

Translation of the author's Dante et la philosophie catholique, Paris, 1839.

Considerazioni intorno all'opera del cavaliere Vincenzo Monti intitolata Proposta di alcune correzioni ed aggiunte al Vocabolario della Crusca,

Mode of access: Internet.

Modelling the behaviour of the new issue market

This paper analyses the time series behaviour of the initial public offering (IPO) market using an equilibrium model of demand and supply that incorporates the number of new issues, average underpricing, and general market conditions. Model predictions include the existence of serial correlation in both the number of new issues and the average level of underpricing, as well as interactions between these variables and the impact of general market conditions. The model is tested using 40 years of monthly IPO data. The empirical results are generally consistent with predictions.

Size and book to market effects and the Fama French three factor asset pricing model: Evidence from the Australian stockmarket

The present study adds to the sparse published Australian literature on the size effect, the book to market (BM) effect and the ability of the Fama French three factor model to account for these effects and to improve on the asset pricing ability of the Capital Asset Pricing Model (CAPM). The present study extends the 1981–1991 period examined by Halliwell, Heaney and Sawicki (1999) a further 10 years to 2000 and addresses several limitations and findings of that research. In contrast to Halliwell, Heaney and Sawicki the current study finds the three factor model provides significantly improved explanatory power over the CAPM, and evidence that the BM factor plays a role in asset pricing.

Use of derivatives in public sector organisations

The present paper develops and tests a model explaining public sector derivative use in terms of budget discrepancy minimization. The model is different from private sector models. Private sector models do not readily translate into the public sector, which typically faces different objectives. Hypotheses are developed and tested using logistic regression over a sample of Australian Commonwealth public sector organizations. It is found that public sector organization derivative use is positively correlated with liabilities and size consistent with the hypotheses concerning budget discrepancy management.

Different routes to pure food allergens: extraction, recombinant techniques and total chemical synthesis for obtaining the plant-food pan-allergen LTP

La richiesta di allergeni puri è in continuo aumento per scopi diagnostici, come standard per metodi di rilevamento e di quantificazione, per l'immunoterapia e per lo studio a livello molecolare dei meccanismi delle reazioni allergiche, al fine di facilitare lo sviluppo di possibili cure. In questa tesi di dottorato sono descritte diverse strategie per l’ottenimento di forme pure di non-specific Lipid Transfer Proteins (nsLTPs), le quali sono state riconosciute essere rilevanti allergeni alimentari in molti frutti e verdure comunemente consumati e sono state definite come modello di veri allergeni alimentari. Una LTP potenzialmente allergenica, non nota in precedenza, è stata isolata dalle mandorle, mentre una LTP dall’allergenicità nota contenuta nelle noci è stata prodotta mediante tecniche di DNA ricombinante. Oltre a questi approcci classici, metodi per la sintesi chimica totale di proteine sono stati applicati per la prima volta alla produzione di un allergene, utilizzando Pru p 3, la LTP prototipica e principale allergene della pesca nell'area mediterranea, come modello. La sintesi chimica totale di proteinepermette di controllarne completamente la sequenza e di studiare la loro funzione a livello atomico. La sua applicazione alla produzione di allergeni costituisce perciò un importante passo avanti nel campo della ricerca sulle allergie alimentari. La proteina Pru p 3 è stata prodotta nella sua intera lunghezza e sono necessari solo due passaggi finali di deprotezione per ottenere il target nella sua forma nativa. Le condizioni sperimentali per tali deprotezioni sono state messe a punto durante la produzione dei peptidi sPru p 3 (1-37) e sPru p 3 (38-91), componenti insieme l'intera proteina. Tecniche avanzate di spettrometria di massa sono state usate per caratterizzare tutti i composti ottenuti, mentre la loro allergenicità è stata studiata attraverso test immunologici o approcci in silico.

Storia e tragedia. P. Oxy. XXIII 2382: edizione critica e commento

Il lavoro consta di un’introduzione dedicata in primis alla presentazione formale di P. Oxy. XXIII 2382, di cui sono posti in evidenza i legami strutturali e concettuali con il racconto di Hdt. I 8-12. Segue dunque la trattazione dei problemi posti da P. Oxy. 2382, quello del genere letterario di appartenenza (tragedia o novella in versi?) e quello della datazione (età classica o età ellenistica?), finalizzata ad una puntuale definizione dello status quaestionis. Le conclusioni mettono in luce gli elementi a favore dell’ipotesi tragica: la presenza di paragraphoi e il passo di Ach. Tat. I 8 4-7 (corredato da un’appendice relativa alla storia del termine δρᾶμα: se e quando tale termine assume l’accezione di ‘narrazione romanzesca’?), nonché il soggetto storico (con un excursus relativo ai drammi di argomento storico). Si evidenziano infine gli elementi di debolezza contenuti nelle ipotesi avanzate da Cantarella (1952) e Lloyd-Jones (1953), propensi a ritenere P. Oxy. 2382 rispettivamente una novella in versi (il che offre lo spunto per una breve trattazione relativa alle caratteristiche contenutistiche e formali delle novelle milesie) e un giambo archilocheo, di cui il fr. 19 W.2 conserverebbe l’incipit. Quanto alla cronologia, sono enumerati i limiti della datazione alta, nonché gli elementi di affinità di P. Oxy. 2382 con la tragedia ellenistica; infine, pensando ad una possibile attribuzione, si propone, in termini puramente ipotetici, il confronto con l’esperienza della Pleiade alessandrina. Segue dunque un’analisi (laddove le condizioni dei testi, spesso frammentarie, lo consentano) dell’opera di Licofrone di Calcide, Sositeo e Sosifane di Siracusa, esponenti della Pleiade, nonché di Moschione ed Ezechiele, volta ad individuare elementi di continuità con P. Oxy. 2382. Il lavoro si conclude con l’edizione critica e il commento verso per verso di P. Oxy. XXIII 2382, corredati da un’appendice dedicata a P. Oxy. XLIV 3161, testo con notazioni musicali apparentemente affine a P. Oxy. XXIII 2382, costituito da 4 frr. notevolmente accidentati, di cui si fornisce l’edizione critica.

Mixing the grant cocktail:towards an understanding of the outcomes of financial support to small firms

One of the key policy objectives of government at national and regional level, is to overcome the constraints preventing local industry achieving greater competitiveness in the international market-place. This paper examines the impact of grant assistance to Northern Ireland small firms delivered over the period 1994 ^ 97 by the former Local Enterprise Development Unit through its Growth Business Support Programme (GBSP). Previous work by the authors showed that there was some tentative evidence to suggest a link between employment growth and grant aid provided to very small firms (fewer than 10 employees) assisted under the GBSP. The central objective of the empirical work reported in this paper is to extend the previous analysis by understanding the extent to which the value of financial assistance influences growth (employment, turnover, and productivity measures) and if differential impacts arise depending on the nature and timing (lag structures) of the grant assistance.

The prediction of vibration in large electric machines

This thesis reports the development of a reliable method for the prediction of response to electromagnetically induced vibration in large electric machines. The machines of primary interest are DC ship-propulsion motors but much of the work reported has broader significance. The investigation has involved work in five principal areas. (1) The development and use of dynamic substructuring methods. (2) The development of special elements to represent individual machine components. (3) Laboratory scale investigations to establish empirical values for properties which affect machine vibration levels. (4) Experiments on machines on the factory test-bed to provide data for correlation with prediction. (5) Reasoning with regard to the effect of various design features. The limiting factor in producing good models for machines in vibration is the time required for an analysis to take place. Dynamic substructuring methods were adopted early in the project to maximise the efficiency of the analysis. A review of existing substructure- representation and composite-structure assembly methods includes comments on which are most suitable for this application. In three appendices to the main volume methods are presented which were developed by the author to accelerate analyses. Despite significant advances in this area, the limiting factor in machine analyses is still time. The representation of individual machine components was addressed as another means by which the time required for an analysis could be reduced. This has resulted in the development of special elements which are more efficient than their finite-element counterparts. The laboratory scale experiments reported were undertaken to establish empirical values for the properties of three distinct features - lamination stacks, bolted-flange joints in rings and cylinders and the shimmed pole-yoke joint. These are central to the preparation of an accurate machine model. The theoretical methods are tested numerically and correlated with tests on two machines (running and static). A system has been devised with which the general electromagnetic forcing may be split into its most fundamental components. This is used to draw some conclusions about the probable effects of various design features.

Can certain genotypes predispose to poor asthma control in children? A pharmacogenetic study of 9 candidate genes in children with difficult asthma

Objective - We tested the hypothesis that patients with difficult asthma have an increased frequency of certain genotypes that predispose them to asthma exacerbations and poor asthma control. Methods - A total of 180 Caucasian children with confirmed asthma diagnosis were selected from two phenotypic groups; difficult (n = 112) versus mild/moderate asthma (n = 68) groups. All patients were screened for 19 polymorphisms in 9 candidate genes to evaluate their association with difficult asthma. Key Results - The results indicated that LTA4H A-9188>G, TNFα G-308>A and IL-4Rα A1727>G polymorphisms were significantly associated with the development of difficult asthma in paediatric patients (p<0.001, p = 0.019 and p = 0.037, respectively). Haplotype analysis also revealed two haplotypes (ATA haplotype of IL-4Rα A1199>C, IL-4Rα T1570>C and IL-4Rα A1727>G and CA haplotype of TNFα C-863>A and TNFα G-308>A polymorphisms) which were significantly associated with difficult asthma in children (p = 0.04 and p = 0.018, respectively). Conclusions and Clinical Relevance - The study revealed multiple SNPs and haplotypes in LTA4H, TNFα and IL4-Rα genes which constitute risk factors for the development of difficult asthma in children. Of particular interest is the LTA4H A-9188>G polymorphism which has been reported, for the first time, to have strong association with severe asthma in children. Our results suggest that screening for patients with this genetic marker could help characterise the heterogeneity of responses to leukotriene-modifying medications and, hence, facilitate targeting these therapies to the subset of patients who are most likely to gain benefit.