Rede von Georg Waltemath gegen die Antisemiten : geh. am 1. Sept. 1891 in d. Versammlung d. Hamburger Vereins d. Deutschen Freisinnigen Partei

Georg Waltemath. Hrsg. vom Vorstand d. Vereins

Novel radiotherapy techniques for involved-field and involved-node treatment of mediastinal Hodgkin lymphoma: when should they be considered and which questions remain open?

PURPOSE Hodgkin lymphoma (HL) is a highly curable disease. Reducing late complications and second malignancies has become increasingly important. Radiotherapy target paradigms are currently changing and radiotherapy techniques are evolving rapidly. DESIGN This overview reports to what extent target volume reduction in involved-node (IN) and advanced radiotherapy techniques, such as intensity-modulated radiotherapy (IMRT) and proton therapy-compared with involved-field (IF) and 3D radiotherapy (3D-RT)- can reduce high doses to organs at risk (OAR) and examines the issues that still remain open. RESULTS Although no comparison of all available techniques on identical patient datasets exists, clear patterns emerge. Advanced dose-calculation algorithms (e.g., convolution-superposition/Monte Carlo) should be used in mediastinal HL. INRT consistently reduces treated volumes when compared with IFRT with the exact amount depending on the INRT definition. The number of patients that might significantly benefit from highly conformal techniques such as IMRT over 3D-RT regarding high-dose exposure to organs at risk (OAR) is smaller with INRT. The impact of larger volumes treated with low doses in advanced techniques is unclear. The type of IMRT used (static/rotational) is of minor importance. All advanced photon techniques result in similar potential benefits and disadvantages, therefore only the degree-of-modulation should be chosen based on individual treatment goals. Treatment in deep inspiration breath hold is being evaluated. Protons theoretically provide both excellent high-dose conformality and reduced integral dose. CONCLUSION Further reduction of treated volumes most effectively reduces OAR dose, most likely without disadvantages if the excellent control rates achieved currently are maintained. For both IFRT and INRT, the benefits of advanced radiotherapy techniques depend on the individual patient/target geometry. Their use should therefore be decided case by case with comparative treatment planning.

Annäherung an die soziale Wirklichkeit der SS-Ärzte. Sprachanalysen und sozialpsychologische Untersuchungen anhand von Hans Münchs Erinnerungserzählungen

Die Arbeit untersucht, wie Tätererinnerungen für die Geschichtswissenschaft nutzbar gemacht werden können. Hans Münch, ein ehemaliger SS-Arzt in Auschwitz, hat sein Leben lang zahlreiche Interviews gegeben. Diese werden einer Sprach- und Diskursanalyse unterzogen und aus sozialpsychologischer Perspektive betrachtet. Dabei wird deutlich, wie die Methodenwahl die Ergebnisse mitbestimmt. Strukturelemente und Rahmenbedingungen, die das Denken und Handeln Münchs beeinflusst haben, werden herausgearbeitet. Dadurch werden die soziale Wirklichkeit der SS-Ärzte sowie die Beweggründe für diesen Genozid auf der Täterebene greifbarer gemacht. Es wird aufgezeigt, wie Münch Brüche in seiner Lebensgeschichte mit einem konsistenten Selbstbild, einer Sinnkonstruktion, zu überdecken versuchte.

Can in-vitro chemoresponse assays help find new treatment regimens for malignant gliomas?

Various in-vitro chemosensitivity and resistance assays (CSRAs) have been demonstrated to be helpful decision aids for non-neurological tumors. Here, we evaluated the performance characteristics of two CSRAs for glioblastoma (GB) cells. The chemoresponse of fresh GB cells from 30 patients was studied in vitro using the ATP tumor chemoresponse assay and the chemotherapy resistance assay (CTR-Test). Both assay platforms provided comparable results. Of seven different chemotherapeutic drugs and drug combinations tested in vitro, treosulfan plus cytarabine (TARA) was the most effective, followed by nimustine (ACNU) plus teniposide (VM26) and temozolomide (TMZ). Whereas ACNU/VM26 and TMZ have proven their clinical value for malignant gliomas in large randomized studies, TARA has not been successful in newly diagnosed gliomas. This seeming discrepancy between in vitro and clinical result might be explained by the pharmacological behavior of treosulfan. Our results show reasonable agreement between two cell-based CSRAs. They appear to confirm the clinical effectiveness of drugs used in GB treatment as long as pharmacological preconditions such as overcoming the blood-brain barrier are properly considered.

Adolph Hannovers faedrene og mødrene Slaegt : 1814 - 24. Nov. - 1914 ; tillige indeholdene Adolph Hannovers Autobiografi samt en Fortegnelse over hans vidensdabelige Arbejder m. m.

udg. i anledning af Hundredaarsdagen for hans Fødsel af martin Ad. Hannover.

Simon Isac Kalkar og hans Slaegt

paa Foranledning af Nic. Abrahamsen ved Josef Fischer