Validação de intervenção educativa em farmacovigilância

A farmacovigilância permite a avaliação do risco/benefício da utilização dos medicamentos disponíveis no mercado. A análise da segurança e da efetividade dos fármacos é realizada, fundamentalmente, pelo método de notificação espontânea de evento adverso a medicamento. Entretanto, este método passivo contém limitações, sendo a principal, a subnotificação dos casos. Portanto, fazem-se necessárias metodologias que contribuam para a promoção da farmacovigilância de modo a contribuir com análise da segurança dos medicamentos e para o uso racional destas tecnologias em saúde. O presente estudo teve como objetivo validar metodologia de intervenção educativa para estimular a notificação de evento adverso a medicamento por profissionais da saúde. A intervenção foi realizada com alunos do curso de Farmácia Bioquímica e da Especialização em Saúde Pública da Faculdade de Ciências Farmacêuticas da Universidade Estadual Paulista “Júlio de Mesquita Filho”. Foram propostos quatro encontros, com duração de uma hora cada, para o desenvolvimento de aula expositiva sobre o tema, com distribuição de material educativo e certificado de participação, realização de dinâmica de grupo para o correto preenchimento da ficha de notificação de evento adverso a medicamento e aplicação de questionário, antes e após a intervenção, para avaliação do impacto sobre o conhecimento/atitude/habilidade em farmacovigilância. Participaram da pesquisa 14 voluntários, os quais aceitaram participar da pesquisa, assinando o termo de consentimento livre esclarecido, sendo 9 alunos de graduação e 5 do curso de especialização, graduados em farmácia 1, enfermagem 2, nutrição 1 e biomédica 1. A análise qualitativa das respostas indicou melhora nas definições e conceitos de farmacovigilância, porém as contestações ainda permaneceram incompletas... (Resumo completo, clicar acesso eletrônico abaixo)

A formação profissional e a aplicação dos modelos de periodização do treinamento desportivo, por treinadores de judô de atletas de elite

Pós-graduação em Ciências da Motricidade - IBRC

Sobre o pensamento bakhtiniano: uma recepção de recepções

There are several receptions of the Bakhtinian work: those which situate it in a cultural and historical perspective, making it possible to understand the context inherent to it, the interchanges with which it was instituted and its development paths; those which separately take one or other of its ideas, and those which search to infer a less or more systemized framework from it in order to consider a specific object. When we concentrate on those last ones and on the field of studies about language, we examine the receptions of the Bakhtinian thought as a pragmatics, a sociolinguistics, a semiotics, a social theory, a theory of the discourse. The perspective of this branch of instruction is the one on which we lastly focus in order to reflect upon some of its fundamental basis.

Subjetividade, individualidade e singularidade na criança: um sujeito que se constitui socialmente

Considering the hypothesis that Bakhtin and his Circle's reflections can help us think about issues involving the field of Language Acquisition, in addition to the fact that there are only a few works developed within this perspective in Brazil, in this article, we intend to discuss the notions of subject, subjectivity, individuality and singularity, drawing on Bakhtin's theory. Thus, in order to make this discussion clearer, we bring data from the speech of young children, from 1.8 to 3 years old, who were filmed in natural contexts interacting with their parents and relatives. From these data, we could verify, among other things, that children, as individuals who constitute themselves as subjects in and through language, bring marks to their discourse, revealing their subjectivity (through lexical, morphological, syntactic or genre choices).

Relações entre gênero e escola no discurso de professoras do ensino fundamental

The school and its teachers have great responsibility in the formation of gender identities. Ten teachers of a public schools participated in a semi-structured interview for the analysis of the content. The teachers perceive gender relations among the students, by their behaviors in the classroom: how quickly are the boys and the whim of the girls, the choice of colors and academic performance distinguished. They also have a concerned about the supposed homosexuality of some boys. The justification on perceived gender differences in students were assigned to the influence of family and to the reproduction of hegemonic standards of gender. Most teachers believe that school has little responsibility in gender issues, highlighting the poor training they had to work with sexual education of their students.

Experiências de conversas nas ruas: aprendizados e questões no estar com o outro

Pós-graduação em Artes - IA

Competências em relações públicas: qualidades profissionais para atuação em comunicação pública

The professional skills desirable to graduates in public relations are defined by many authors of scientific specialized literature, and are continually developed throughout the academic life of the PR student. There are many opportunities of learning aspects such as professional behavior, responsibilities and challenges in the activity's various branches. The field of public communication has particularities that must be respected in order to have an effective communication process with quality and focused vision for citizenship building. This paper examines the specificities of public communication in Brazil, characterized by innovations of the right to information on public social policies, and offers a contribution to the characterization of the necessary skills and abilities of the communicator of this field in the contemporary scenario

A análise do discurso diante de estranhos espelhos: visualidade e (inter)discursividade na pintura

This paper aims to understand the discursive dimension of some paintings through Michel Foucault'sdiscourse analysis approach. The image of the mirror in several canonical paintings was selected, intending to observe its discursive operation as an element of the visual artistic utterance. Basically, this text has three parts: firstly, it determines the place occupied by the aesthetic discourse in Michel Pêcheux's and Michel Foucault's works; secondly, it focuses on the analysis of three European paintings, namely The Maids of Honour by Velásquez, A Bar at the Folies-Bergère by Manet, and Dangerous Liaisons by Magritte; thirdly, it discusses the intersection between visuality and interdiscursivity based on a) the contributions of M. Foucault's works on aesthetic discourse and b) the image of the mirror found in those paintings.

Diretrizes de conduta e tratamento de síndromes febris periódicas associadas à criopirina (Criopirinopatias–CAPS)

To establish guidelines based on cientific evidences for the management of cryopyrin associated periodic syndromes. The Guideline was prepared from 4 clinical questions that were structured through Pico (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 1215 articles were retrieved and evaluated by title and abstract; from these, 42 articles were selected to support the recommendations. 1. The diagnosis of Caps is based on clinical history and clinical manifestations, and later confirmed by genetic study. Caps may manifest itself in three phenotypes: FCAS (mild form), MWS (intermediate form) and Cinca (severe form). Neurological, ophthalmic, otorhinolaryngological and radiological assessments may be highly valuable in distinguishing between syndromes; 2. The genetic diagnosis with NLRP3 gene analysis must be conducted in suspected cases of Caps, i.e., individuals presenting before 20 years of age, recurrent episodes of inflammation expressed by a mild fever and urticaria; 3. Laboratory abnormalities include leukocytosis and elevated serum levels of inflammatory proteins; 4. Targeted therapies directed against interleukin-1 lead to rapid remission of symptoms in most patients. However, there are important limitations on the long-term safety. None of the three anti-IL-1β inhibitors prevents progression of bone lesions.

Diretrizes de conduta e tratamento de síndromes febris periódicas: síndrome de febre periódica, estomatite aftosa, faringite e adenite

To establish guidelines based on scientific evidence for the management of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 806 articles were retrieved and evaluated by title and abstract; from these, 32 articles were selected to support the recommendations. 1. PFAPA is a diagnosis of exclusion established on clinical grounds, and one must suspect of this problem in children with recurrent and periodic febrile episodes of unknown origin, or with recurrent tonsillitis interspersed with asymptomatic periods, especially in children in good general condition and with preservation of weight and height development; 2. Laboratory findings are nonspecific. Additional tests do not reveal pathognomonic changes; 3. The evidence supporting an indication for surgical treatment (tonsillectomy with or without adenoidectomy), is based on two non-blinded randomized clinical trials with small numbers of patients; 4. The use of prednisone at the onset of fever in patients with PFAPA proved to be an effective strategy. There is still need for more qualified evidence to support its use in patients with PFAPA; 5. Despite promising results obtained in studies with IL-1ß inhibitors, such studies are limited to a few case reports.

Guidelines for the management and treatment of periodic fever syndromes Familial Mediterranean Fever

To establish guidelines based on scientific evidence for the management of familial Mediterranean fever. The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 10,341 articles were retrieved and evaluated by title and abstract; from these, 46 articles were selected to support the recommendations. 1. The diagnosis of FMF is based on clinical manifestations, characterized by recurrent febrile episodes associated with abdominal pain, chest or arthritis of large joints; 2. FMF is a genetic disease presenting an autosomal recessive trait, caused by mutation in the MEFV gene; 3. Laboratory tests are not specific, demonstrating high serum levels of inflammatory proteins in the acute phase of the disease, but also often showing high levels even between attacks. SAA serum levels may be especially useful in monitoring the effectiveness of treatment; 4. The therapy of choice is colchicine; this drug has proven effectiveness in preventing acute inflammatory episodes and progression towards amyloidosis in adults; 5. Based on the available information, the use of biological drugs appears to be an alternative for patients with FMF who do not respond or are intolerant to therapy with colchicine.

Análise da proteína EGFR em carcinoma espinocelular de lábio

Pós-graduação em Biopatologia Bucal - ICT

Avaliação do grau de conhecimento sobre Leishmaniose e Toxoplasmose em moradores do município de Araçatuba, SP

Considering the importance of zoonotic infections by Leishmania spp. and Toxoplasma gondii in Araçatuba region, São Paulo, this study determined the degree of knowledge of residents of Araçatuba about these two diseases. Questionnaires about these diseases were applied to 123 people. Regarding schooling, all the respondents were literate, and 69.9% (86/123) did not attend higher education and 30.8% (37/123) completed an undergraduate degree. Of these, 91.9% (34/37) knew the meaning of the term zoonosis, with significant difference compared to those who were not trained. This word was unknown by 57% (29/123) of total respondents. Most non-graduates, 59.3% (51/86) did not know what is toxoplasmosis and among graduates, 35.1% (13/37) ignored the subject.There were significant difference between these groups. Regarding the prevention of Leishmania infection, a greater proportion of the residents advocated environmental cleanup, the collar repellent and use of citronella. In relation to toxoplasmosis, 54.5% did not know the ways of transmission of this disease and among those with graduate degree, 13 ignoring any transmission medium. When it comes to prevention of this disease, 55.3% (68/123) did not know any prophylactic. In the group of higher education, 14 did not know how to prevent toxoplasmosis. The results of this study show that the majority of respondents are not aware about the mode of transmission of these diseases, especially in relation to toxoplasmosis.

La relacion entre la calidad de la ensenanza y mala prática odontológica: relato de un caso clínico

The activities developed in health area are of great importance, because they have the aim to preserve the life of the men, and therefore, must be performed by authorized persons. The increase of the number of dental schools, the decline at the education quality and a higher admission of students with low ability to exercise their profession, are facts that bring disastrous consequences for society. These facts are, also, reflected at the moral, ethical and technical-scientific performance of the professional. The purpose of this clinic case is to show that although there is a significant suplly of education institutions, there is a lack of scientific and adequate technical knowledgement from the graduated dentals surgeons. The patient MSL, 17 year old, female, went to a dental clinic presenting a tray type Vernis, attached to the lower arch. After clinical evaluation, it was showed that an incorrect material was used for the impression technique, being impossible to take out the tray by the conventional manner. The planning for the removal of the tray was through the divide of it. Thus, the consequence of the lack of knowledge in the use of impression materials had caused a great incovinience to the patient. It can be concluded that the rate of malpractice is directly related to the professional preparation, highlighting the importance of quality dental education for a responsible clinical practice.

Exercício físico aeróbio para promoção da saúde de pacientes com doença de Alzheimer

Introdução: Sabe-se que a prática regular e sistematizada de atividade física é uma eficiente estratégia para evitar a deterioração cognitiva e funcional associada à Doença de Alzheimer (DA), uma doença progressiva, degenerativa e irreversível. Na população idosa os benefícios observados com a prática de exercícios físicos aeróbios já se encontram bem estabelecidos, contudo pouco ainda se sabe quanto à prática deste tipo de atividade em pacientes com DA. Em estudos realizados com modelo animal pode-se observar que o exercício físico aeróbio foi capaz de reduzir os níveis da proteína β-amilóide, sendo esta uma proteína característica da DA, que provoca degeneração no cérebro dos pacientes. A redução dos marcadores característicos da doença pode promover benefícios para os pacientes. Objetivos: Promover a prática de exercícios físicos para promoção/manutenção da saúde de pacientes com DA. Métodos: O estudo está sendo desenvolvido no PRO-CDA (Programa de Cinesioterapia Funcional e Cognitiva em Idosos com Doença de Alzheimer), projeto de Extensão do Departamento de Educação Física da UNESP – Campus Rio Claro, vinculado ao Núcleo Local UNESP-UNATI. O projeto atende atualmente 34 pacientes, divididos em dois grupos: Grupo Convívio Social e Grupo Exercício. O primeiro tem por objetivo desenvolver a adaptação do paciente à rotina do projeto. Já o segundo grupo busca promover os benefícios observados com a prática de atividade física nos pacientes participantes. Ambos os grupos realizam atividades três vezes na semana, com 60 minutos de duração cada sessão. O projeto conta com a participação de alunos de graduação, dos cursos de educação física, pedagogia e biologia, bem como discentes de pós-graduação da UNESP, além de aprimorandos graduandos e graduados dos cursos de educação física, fisioterapia, gerontologia e psicologia de outras universidades, que atuam sob a coordenação de docentes vinculados ao Departamento de Educação Física e de Educação. Resultados: Por se tratar de um protocolo de intervenção motora iniciado recentemente, o presente estudo ainda não apresenta resultados. Contudo protocolos de atividade física desenvolvidos anteriormente no PRO-CDA evidenciam melhora na realização de atividades de vida diária, manutenção das funções cognitivas, qualidade de vida e redução dos distúrbios de comportamento nos pacientes participantes. Espera-se que o protocolo de exercício físico aeróbio possa influenciar positivamente os participantes do projeto, com melhora na qualidade de vida, tanto de pacientes como de cuidadores, redução de sintomas depressivos, melhora dos distúrbios do sono e da condição motora.