Avaliação genética de seleções e híbridos de limões cravo, volkameriano e rugoso como porta-enxertos para laranjeiras Valência na presença da morte súbita dos citros

Este estudo teve como objetivo realizar a avaliação genética da produção de frutos, eficiência produtiva e altura de laranjeiras Valência (Citrus sinensis) enxertadas em seleções e híbridos dos limões Cravo (C. limonia), Volkameriano (C. volkameriana) e Rugoso (C. jambhiri), em área endêmica para morte súbita dos citros (MSC). Foram avaliados 36 genótipos desses porta-enxertos, representados por cinco plantas cada, avaliados em cinco safras, do terceiro ao sétimo ano após o plantio. Sete dos genótipos avaliados apresentaram plantas com sintomas de MSC até o sétimo ano: Rangpur Otaheite orange 12901 (859), Rangpur Red Lime D.33.30 (866), Limão-Cravo EEL (871), Rangpur Borneo red (874), Citrus kokhai (1649), Limão-Rugoso 58329 (1655) e Limão- Cravo x Swingle B (1695). Para os genótipos que não manifestaram sintomas da doença, foram estimados parâmetros genéticos e fenotípicos e realizada a predição de valores genéticos dos indivíduos, visando à seleção e ao melhoramento genético para as características citadas, empregando-se o método REML/BLUP (máxima verossimilhança restrita/melhor predição linear não viciada). A análise de produção de frutos de cinco safras mostrou acurácia seletiva de 84,59%, tornando-se desnecessária a avaliação de maior número de safras. A seleção dos sete melhores genótipos proporcionou ganhos genéticos de 11,5% na produção de frutos, enquanto a do melhor genótipo conferiu ganho genético de 16,3%. As maiores médias genéticas preditas (>70,0 kg.pl-1) para produção de frutos foram obtidas pelos genótipos Limão-Cravo- Ipanema (1522), Santa- Bárbara-Red- Lime (884), Limão- Cravo- Limeira (863), Limão- Cravo- Taquaritinga (869), Limão- Rugoso- do -Cabo (1643), Rangpur- Rose Lime (868) e Limão- Cravo- da- Califórnia (1467). Já a acurácia seletiva da eficiência produtiva, para quatro colheitas, foi 77,4%. Para este caráter, as maiores médias genéticas (>8,0 kg.m-3) foram dos genótipos Rangpur- Lime x Trifoliata 3810 (1648), Rangpur- Lime x Trifoliata 5320 (1644), Limão- Cravo x Citrange- Carrizo (1524), Citrus pennivesiculata (880), Limão- Cravo x Trifoliata- Swingle A (1707), Rangpur- Rose- Lemon 124684 (864), Rangpur- Red -Lime D33.47 (867) e Limão- Cravo -Ipanema (1522). Dentre os 10 melhores genótipos para produção de frutos e para eficiência produtiva, apenas três são coincidentes: Rangpur- Rose -Lime (868), Citrus pennivesiculata (880) e Limão- Cravo-Ipanema (1522).

Directional dominance on stature and cognition in diverse human populations.

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.

El Jardín de Falerina, Francisco de Rojas Zorrilla, Antonio Coello Ochoa y Pedro Calderón de la Barca. Edición, introducción y notas de Felipe B. Pedraza Jiménez y Rafael González Cañal, (Barcelona: Octaedro, 2010)

Parece mentira que una pieza teatral firmada por Calderón de la Barca haya tardado más de tres cientos años en aparecer impresa y que sea ahora,en el 2010, cuando lo haga por primera vez. ¿A qué se debe esta falta de interés por la obra?La respuestanos la ofrecen Felipe B. Pedza Jiménez y Rafael González Cañal en el capítulo que abre el estudio preliminar de su edicion tulado«Razones de una sin razón»

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension

Genome-wide association studies (GWASs) have identified many genetic variants underlying complex traits. Many detected genetic loci harbor variants that associate with multiple-even distinct-traits. Most current analysis approaches focus on single traits, even though the final results from multiple traits are evaluated together. Such approaches miss the opportunity to systemically integrate the phenome-wide data available for genetic association analysis. In this study, we propose a general approach that can integrate association evidence from summary statistics of multiple traits, either correlated, independent, continuous, or binary traits, which might come from the same or different studies. We allow for trait heterogeneity effects. Population structure and cryptic relatedness can also be controlled. Our simulations suggest that the proposed method has improved statistical power over single-trait analysis in most of the cases we studied. We applied our method to the Continental Origins and Genetic Epidemiology Network (COGENT) African ancestry samples for three blood pressure traits and identified four loci (CHIC2, HOXA-EVX1, IGFBP1/IGFBP3, and CDH17; p < 5.0 × 10(-8)) associated with hypertension-related traits that were missed by a single-trait analysis in the original report. Six additional loci with suggestive association evidence (p < 5.0 × 10(-7)) were also observed, including CACNA1D and WNT3. Our study strongly suggests that analyzing multiple phenotypes can improve statistical power and that such analysis can be executed with the summary statistics from GWASs. Our method also provides a way to study a cross phenotype (CP) association by using summary statistics from GWASs of multiple phenotypes.

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.

Arithmetica eller een kort och eenfaldigh räknebook

Aegidius Aurelius (1500-luvun loppupuoli -1648 ) oli Uppsalassa syntynyt oppikirjantekijä ja opettaja. Laskuopin opetus Euroopan kouluissa yleistyi vasta 1600-luvulta alkaen, ja ensimmäiset oppikirjat olivat latinankielisiä. Aureliuksen Arithmetica on ensimmäinen painettu ruotsinkielinen matematiikan oppikirja, jota käytettiin Ruotsin kouluissa yli sadan vuoden ajan. Kansalliskirjaston hallussa oleva, kirjan ensimmäisen painoksen kappale on myös tämän teoksen ainoa tunnettu kappale maailmassa. Se on aikoinaan merkintöjen mukaan kuulunut 1700-luvun suomalaisille koululaisille.

Seguidilles, fandangos i boleros a les sonates ibèriques per tecla dels compositors Domenico Scarlatti, José de Nebra i Antoni Soler

Aquest projecte neix amb la finalitat d’oferir una perspectiva sobre les sonates ibèriques de les dècades centrals del segle XVIII, i en concret dels cèlebres compositors Domenico Scarlatti, José de Nebra i Antoni Soler, centrada en alguns dels balls de major popularitat a l’època com són les seguidilles, els fandangos i els boleros. Algunes de les sonates ibèriques d’aquests compositors es corresponen amb molts dels paràmetres que condicionen aquests balls i com a conseqüència són sonates que poden ser ballades, tot i que desconeixem si a l’època s’interpretaven amb ballarins. Al voltant d’aquest tema se’ns formulen algunes preguntes referents al gènere i l’estil de les sonates o a la relació dels seus compositors amb els moviments culturals de la ciutat de Madrid que podien haver propiciat aquesta connexió.

Manuale Lapponicum

Manuale Lapponicum on Johannes Tornaeuksen ruotsin kielestä (Manuale Sueticum) saamen kielelle kääntämä teos, joka sisältää kirkkokäsikirjan, katekismuksen, raamatun kirjoja, laulukirjan ja rukouskirjan. Tornaeus oli Upsalassa opiskellut Ala-Tornion kirkkoherra, joka koetti käännöksessään noudattaa "keskitietä" eli sellaista kielimuotoa, jonka kaikki lappalaiset ymmärtäisivät. Kielestä tuli kuitenkin näin hieman kankea ja keinotekoinen.

Lectores de Saavedra Fajardo en la Alemania ilustrada: Leipzig y la traducción alemana de 'Locuras de Europa'

Se analiza la recepción de Diego de Saavedra Fajardo en la Alemania ilustrada del siglo XVIII, donde se imprimieron y tradujeron algunas obras de este autor. A través del análisis del prólogo que precede la edición alemana de Locuras de Europa, conoceremos el universo editorial que impulsó su aparición en Leipzig y la conyuntura histórico-política que lo propició

Un manuscrito inédito de "Suspiros de Francia" de Saavedra Fajardo

El descubrimiento de un nuevo manuscrito inédito de Suspiros de Francia, texto que forma parte del conjunto de obras panfletarias del escritor y diplomático Diego de Saavedra Fajardo, ayuda a establecer un nuevo texto crítico de notable calidad, con la aclaración de algunos pasajes que hasta ahora habían sido confusos. Asimismo, los paralelismos que se establecen entre Suspiros y Empresas políticas permiten analizar el proceso de la reescritura en la obra literaria de Diego de Saavedra Fajardo

La Connoissance des temps, ou calendrier et éphémérides du lever & coucher du soleil, de la lune, & des autres planètes...

1729.

La Transmisión textual de Locuras de Europa de Diego de Saavedra Fajardo

Treball de investigació centrat en la crítica textual on es descriuen atentament tots els testimonis que s’han conservat de l’obra tardana de Diego de Saavedra Fajardo “Locuras de Europa,” ambaixador i escriptor murcià. Es realitza una anàlisi exhaustiva dels quatre manuscrits i de les dues edicions impreses de l’obra per acabar filiant tots els testimonis en un stemma. El cos del treball es complementa amb el text crític final i amb un apartat crític

Exercitium academicum

Invocatio: Deo duce.

De diversis philosophor. methodis in demonstranda existentia Dei

Invocatio: Q.F.F.Q.S.