Influence of Spironolactone on Matrix Metalloproteinase-2 in Acute Decompensated Heart Failure

Background: Matrix metalloproteinases (MMPs) are a family of enzymes important for the resorption of extracellular matrices, control of vascular remodeling and repair. Increased activity of MMP2 has been demonstrated in heart failure, and in acutely decompensated heart failure (ADHF) a decrease in circulating MMPs has been demonstrated along with successful treatment. Objective: Our aim was to test the influence of spironolactone in MMP2 levels. Methods: Secondary analysis of a prospective, interventional study including 100 patients with ADHF. Fifty patients were non-randomly assigned to spironolactone (100 mg/day) plus standard ADHF therapy (spironolactone group) or standard ADHF therapy alone (control group). Results: Spironolactone group patients were younger and had lower creatinine and urea levels (all p < 0.05). Baseline MMP2, NT-pro BNP and weight did not differ between spironolactone and control groups. A trend towards a more pronounced decrease in MMP2 from baseline to day 3 was observed in the spironolactone group (-21 [-50 to 19] vs 1.5 [-26 to 38] ng/mL, p = 0.06). NT-pro BNP and weight also had a greater decrease in the spironolactone group. The proportion of patients with a decrease in MMP2 levels from baseline to day 3 was also likely to be greater in the spironolactone group (50% vs 66.7%), but without statistical significance. Correlations between MMP2, NT-pro BNP and weight variation were not statistically significant. Conclusion: MMP2 levels are increased in ADHF. Patients treated with spironolactone may have a greater reduction in MMP2 levels.

Flora of Peru : Euphorbiaceae, spurge family / J. Francis MacBride.

v.13:pt.3A:no.1 (1951) [Euphorbiaceae]

A revision of the Family Geastraceae.

v.31:no.14(1968)

Effect of day time on foliar spraying of several levels of nitrogen fertilizer, NPKS solutions and its components, on common bean leaves

An experiment was carried out in order to determine the effect of day time of foliar spraying of several levels of nitrogen fertilizers, N-P-K-S station, and its components on common bean leaves. Results, based on the visual observations, indicated the maximum levels of each fertilizer that did not cause injuries and showed that the foliar spraying early in the morning is the best day time.

Family Asteraceae, part V : [tribe Inuleae] / Michael O. Dillon, Abundio Sagástegui Alva.

n.s. no.26(1991)

Flora Costaricensis. William Burger, editor. Family #40, Casuarinaceae, Family #41, PIperaceae [by] William Burger.

v.35(1971)

Flora of Peru: Family compositae : Walter C. Holmes, Sidney McDaniel.

n.s. no.9(1982)

Flora Costaricensis : Family #200, Acanthaceae by L.H. Durkee, Family #201, Plantaginaceae by William Burger.

n.s. no.18(1986)

Mammals of the Collins-Day South American expedition, by Wilfred H. Osgood.

v.10:no.14(1916)

Austral Hepaticae the genus Balantiopsis in New Zealand, with observations on extraterritorial taxa and a phylogeny of Balantiopsis and the family Balantiopsaceae (Jungermanniales) / John J. Engel, G.L. Smith Merrill.

n.s. no.37(1997)

Family #15, Gramineae / Richard W. Pohl.

n.s. no.4(1980)

Two new rodent genera from the Oligocene White River formation (family Heteromyidae) / William G. Reeder --

v.10:no.35(1960)