Pilot study about the effect of rt-PA administration on the excitotoxicity mediated brain damage and its repercussion on the functional prognosis of patients with ischaemic stroke: research protocol

Fibrinolytic therapy with Recombinant Tissue-Plasminogen Activator (rt-PA) is currently the only effective treatment for ischaemic stroke in its acute phase. Even though its use generally improves the prognosis of those patients likely to receive it, rt-PA administration is associated to several risks, such as haemorrhagic transformation ofthe ischaemic lesion and activation of excitotoxic mechanisms that may contribute to an increase in mortality or to a poor outcome in certain occasions, specially when arterial recanalization is not achieved or the rt-PA is lately administrated. Since in the last few years the role of glutamate in the neurotoxicity associated toischaemia has been widely studied and it is known that high plasma glutamate levels are predictors of ischaemic lesion growth and poor neurological outcome, it is necessary to find out which factors can contribute to glutamate release in the brain. The aim of this study is to determine if rt-PA administration is related to an increase in plasma glutamate levels, as well as to define if higher plasma glutamate levels at admission are related to different evolution and prognosis of our patients, both in those in which recanalisation is achieved and not. A series of cases of patients with hemispheric cerebral infarction admitted in our hospital during a year will be studied, and the data obtained from them will be compared to the data obtained from a control group, the samples of wich were takenyears ago, before rt-PA was routinely used

La Palma - Nova Classis: a Publius Cornelius Scipio Africanus encampment during the Second Punic War in Iberia

This paper presents the discovery of the oldest Roman camp on the Iberian Peninsula, a camp from the Second Punic War situated in La Palma (Tarragona, Spain), by the mouth of the River Ebro. Although no structural remains have been found, the site's strategic in- terest along with many coins, arms and fragments of amphoras and other objects indicate that a military camp was established here between 218 and 209 BC. Written sources, mainly Polybius and Livy, suggest that La Palma was where the legions of Publius Cornelius Scipio gathered before the attack on Carthago Nova in 209 BC. The paper ends by suggesting that La Palma may be the Roman camp of Nova Classis mentioned by Livy during the events of the war in 217 BC.

Determinação da composição isotópica de estrôncio em águas naturais: exemplos de sua aplicação em águas subsuperficiais da zona costeira na região Bragantina-PA

Analytical procedures used for determining the concentrations and isotope composition of strontium in subsurface waters, by mass spectrometry, are described. Sampling was performed in coastal plateaus, salt marsh and mangrove environments in the coastal region of Pará. Coastal plateau waters have delta87Sr between 1.51 and 6.26‰ and Sr concentration bellow 58 ppb. Salt marsh waters show delta87Sr between 0.55 and 0.90‰ and Sr concentration between 93 and 114 ppm, while mangrove waters have delta87Sr‰ around zero and Sr concentration above 15 ppm. Differences in the 87Sr/86Sr ratio in these subsurface waters are detected, as well as seasonal variations in the coastal pleteau waters.

Teores de nitrato (NO3-) e amônio (NH4+) nas águas do aqüífero Barreiras nos bairros do Reduto, Nazaré e Umarizal - Belém/PA

This paper evaluates the occurrence of nitrate and ammonium in the Barreiras aquifer in the metropolitan area of Belém, Pará State, Brazil. The results show that some wells display ammonium and nitrate concentrations above or close to the limits of water potability regulations. The main cause of the pollution of these waters is related the local disposal of domestic effluents and/or leakage from pipes of old sewage systems.

War Requiem op. 66

Digitoitu 5. 1. 2009

Vuer af Helsingfors år 1838 / stentryck af F. Tengström

Vuorimestari Fredrik Tengström (1799-1871) perusti Helsinkiin Suomen ensimmäisen kivipainon vuonna 1834. Tätä aikaisemmin kuva- ja karttatyöt oli jouduttu teettämään ulkomaisissa painoissa. Myös kaivertajista oli Suomessa ollut pulaa. Tengströmin painama ja osittain piirtämäkin Helsinki-sarja esitteli kaupungin uutta empire-keskustaa, josta tuli maisemakuvauksen suosittu kohde. Osa kuvista pohjautui Magnus von Wrightin ja C. E. Westlingin luonnoksiin. Rakennustaide herätti ihastusta, ja aikalaiset kyselivätkin, oliko Perikleen Ateena yhtäkkiä siirtynyt Helsinkiin. Senaatintori-panoraamassa näkyvä päävartio purettiin vuonna 1840 Nikolainkirkon portaiden tieltä.

The Brazilian and patagonian fishes of the wilkes expedition: 1838-1842

Na viagem efetuada à volta do mundo pela U. S. Exploring Expedition mais conhecida pelo nome de Expedição Wilkes e durante o período em que a mesma operava no Atlântico Ocidental, foram visitadas as regiões do Rio de Janeiro e da Patagônia. Por ocasião da festa comemorativa do centenário da The American Philosophical Society, de Filadélfia, ocorrida a 23 de Fevereiro de 1930, o autor teve a oportunidade de apresentar uma nota prévia da qual constava uma lista de peixes capturados durante o cruzeiro da Expedição. Teve, então, o ensejo de examinar o diário redigido pelo Dr. Charles Pickering, botânico da Expedição, nele encontrando anotações valiosas para a História Natural, considerada em seu sentido amplo, detalhes a respeito das localidades percorridas e relações extensas de animais e plantas, além de diversos representantes pertencentes a outros grupos. Sob o ponto de vista histórico, os comentários aí constantes são de importância significativa. Em muitos casos, essas apreciações fornecem base sólida para a efetivação de estudos faunísticos, de caráter comparativo, muito instrutivos e úteis. O autor examinou a coleção de peixes da Expedição Wilkes que se encontra no Museu Nacional dos Estados Unidos, em Washington, acervo esse gentilmente posto à sua disposição para estudo. Dessa maneira, no presente trabalho, fornece matéria de amplo interesse histórico, visando com isso lançar alguma luz sobre a imensa fauna do Brasil e da Argentina. Baseando-se nos dados fornecidos por Pickering, o autor divulga dados curiosos a respeito da baía do Rio de Janeiro e adjacências, no ano de 1838. Segue-se uma lista contendo a diagnose de 82 espécimes de água doce, salobra e salgada, estudados e comparados com outros de várias procedências. Referindo-se ao Rio Negro, descreve o autor o aspeto da região patagônica, durante certo período de 1839, fazendo comentários a respeito de 7 espécies de peixes nela, encontradas.