University Symphony and Student Soloists in a Concerto Concert, January 13, 1963

Concert program for University Symphony and Student Soloists in a Concerto Concert, January 13, 1963

University Concert Band, December 6, 1964

Concert program for University Concert Band, December 6, 1964

Concert of Harpsichord Music, November 3, 1966

Concert Program for Concert of Harpsichord Music, November 3, 1966

A Concert of 17th and 18th Century Music, November 16, 1953

Concert Program for A Concert of 17th and 18th Century Music, November 16, 1953

Noon Concert, William Bolcom, Harrison Ryker, Bruce Bailey, February 1, 1966

Concert Program for Noon Concert, William Bolcom, Harrison Ryker, Bruce Bailey, February 1, 1966

A Concert of Japanese Music, January 20, 1966

Concert Program for A Concert of Japanese Music, January 20, 1966

A Concert of Works by Ross Lee Finney, 1966

Concert Program for A Concert of Works by Ross Lee Finney, 1966

A Concert of American Music, February 9, 1964

Concert Program for A Concert of American Music, February 9, 1964

Concerto Concert with Members of the University Symphony Orchestra, May 14, 1969

Concert program for Concerto Concert with members of the University Symphony Orchestra, May 14, 1969

The Winter Jazz Concert, December 8, 1976

Concert program for The Winter Jazz Concert, December 8, 1976

Annual Christmas Concert, December 14, 1933

Concert Program for Annual Christmas Concert, December 14, 1933

Concert Program for Mallet Head Series, Mallet Jazz October 19, 2012

Concert Program

Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina.

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors. The nuclear hormone receptor gene Rev-erb alpha/Nr1d1 has been widely studied for its role in the circadian cycle and cell metabolism, however its role in the retina is unknown. In order to understand the role of Rev-erb alpha/Nr1d1 in the retina, we evaluated the effects of loss of Nr1d1 to the developing retina and its co-regulation with the photoreceptor-specific nuclear receptor gene Nr2e3 in the developing and mature retina. Knock-down of Nr1d1 expression in the developing retina results in pan-retinal spotting and reduced retinal function by electroretinogram. Our studies show that NR1D1 protein is co-expressed with NR2E3 in the outer neuroblastic layer of the developing mouse retina. In the adult retina, NR1D1 is expressed in the ganglion cell layer and is co-expressed with NR2E3 in the outer nuclear layer, within rods and cones. Several genes co-targeted by NR2E3 and NR1D1 were identified that include: Nr2c1, Recoverin, Rgr, Rarres2, Pde8a, and Nupr1. We examined the cyclic expression of Nr1d1 and Nr2e3 over a twenty-four hour period and observed that both nuclear receptors cycle in a similar manner. Taken together, these studies reveal a novel role for Nr1d1, in conjunction with its cofactor Nr2e3, in regulating transcriptional networks critical for photoreceptor development and function.