Drug treatment of macular oedema secondary to central retinal vein occlusion: a network meta-analysis

Objective
To indirectly compare aflibercept, bevacizumab, dexamethasone, ranibizumab and triamcinolone for treatment of macular oedema secondary to central retinal vein occlusion using a network meta-analysis (NMA).

Design
NMA.

Data sources
The following databases were searched from January 2005 to March 2013: MEDLINE, MEDLINE In-process, EMBASE; CDSR, DARE, HTA, NHSEED, CENTRAL; Science Citation Index and Conference Proceedings Citation Index-Science.

Eligibility criteria for selecting studies
Only randomised controlled trials assessing patients with macular oedema secondary to central retinal vein occlusion were included. Studies had to report either proportions of patients gaining ≥3 lines, losing ≥3 lines, or the mean change in best corrected visual acuity. Two authors screened titles and abstracts, extracted data and undertook risk of bias assessment. Bayesian NMA was used to compare the different interventions.

Results
Seven studies, assessing five drugs, were judged to be sufficiently comparable for inclusion in the NMA. For the proportions of patients gaining ≥3 lines, triamcinolone 4 mg, ranibizumab 0.5 mg, bevacizumab 1.25 mg and aflibercept 2 mg had a higher probability of being more effective than sham and dexamethasone. A smaller proportion of patients treated with triamcinolone 4 mg, ranibizumab 0.5 mg or aflibercept 2 mg lost ≥3 lines of vision compared to those treated with sham. Patients treated with triamcinolone 4 mg, ranibizumab 0.5 mg, bevacizumab 1.25 mg and aflibercept 2 mg had a higher probability of improvement in the mean best corrected visual acuity compared to those treated with sham injections.

Conclusions
We found no evidence of differences between ranibizumab, aflibercept, bevacizumab and triamcinolone for improving vision. The antivascular endothelial growth factors (VEGFs) are likely to be favoured because they are not associated with steroid-induced cataract formation. Aflibercept may be preferred by clinicians because it might require fewer injections.

A method for under-sampled ecological network data analysis: plant-pollination as case study

In this paper, we develop a method, termed the Interaction Distribution (ID) method, for analysis of quantitative ecological network data. In many cases, quantitative network data sets are under-sampled, i.e. many interactions are poorly sampled or remain unobserved. Hence, the output of statistical analyses may fail to differentiate between patterns that are statistical artefacts and those which are real characteristics of ecological networks. The ID method can support assessment and inference of under-sampled ecological network data. In the current paper, we illustrate and discuss the ID method based on the properties of plant-animal pollination data sets of flower visitation frequencies. However, the ID method may be applied to other types of ecological networks. The method can supplement existing network analyses based on two definitions of the underlying probabilities for each combination of pollinator and plant species: (1), pi,j: the probability for a visit made by the i’th pollinator species to take place on the j’th plant species; (2), qi,j: the probability for a visit received by the j’th plant species to be made by the i’th pollinator. The method applies the Dirichlet distribution to estimate these two probabilities, based on a given empirical data set. The estimated mean values for pi,j and qi,j reflect the relative differences between recorded numbers of visits for different pollinator and plant species, and the estimated uncertainty of pi,j and qi,j decreases with higher numbers of recorded visits.

An Upgrade of Network Traffic Recognition System for SIP/VoIP Traffic Recognition

The purpose of this project is to update the tool of Network Traffic Recognition System (NTRS) which is proprietary software of Ericsson AB and Tsinghua University, and to implement the updated tool to finish SIP/VoIP traffic recognition. Basing on the original NTRS, I analyze the traffic recognition principal of NTRS, and redesign the structure and module of the tool according to characteristics of SIP/VoIP traffic, and then finally I program to achieve the upgrade. After the final test with our SIP data trace files in the updated system, a satisfactory result is derived. The result presents that our updated system holds a rate of recognition on a confident level in the SIP session recognition as well as the VoIP call recognition. In the comparison with the software of Wireshark, our updated system has a result which is extremely close to Wireshark’s output, and the working time is much less than Wireshark. In the aspect of practicability, the memory overflow problem is avoided, and the updated system can output the specific information of SIP/VoIP traffic recognition, such as SIP type, SIP state, VoIP state, etc. The upgrade fulfills the demand of this project.

Spam filtering for network traffic security on a multi-core environment

This paper presents an innovative fusion-based multi-classifier e-mail classification on a ubiquitous multicore architecture. Many previous approaches used text-based single classifiers to identify spam messages from a large e-mail corpus with some amount of false positive tradeoffs. Researchers are trying to prevent false positive in their filtering methods, but so far none of the current research has claimed zero false positive results. In e-mail classification false positive can potentially cause serious problems for the user. In this paper, we use fusion-based multi-classifier classification technique in a multi-core framework. By running each classifier process in parallel within their dedicated core, we greatly improve the performance of our multi-classifier-based filtering system in terms of running time, false positive rate, and filtering accuracy. Our proposed architecture also provides a safeguard of user mailbox from different malicious attacks. Our experimental results show that we achieved an average of 30% speedup at an average cost of 1.4 ms. We also reduced the instances of false positives, which are one of the key challenges in a spam filtering system, and increases e-mail classification accuracy substantially compared with single classification techniques.

A novel semi-supervised approach for network traffic clustering

Network traffic classification is an essential component for network management and security systems. To address the limitations of traditional port-based and payload-based methods, recent studies have been focusing on alternative approaches. One promising direction is applying machine learning techniques to classify traffic flows based on packet and flow level statistics. In particular, previous papers have illustrated that clustering can achieve high accuracy and discover unknown application classes. In this work, we present a novel semi-supervised learning method using constrained clustering algorithms. The motivation is that in network domain a lot of background information is available in addition to the data instances themselves. For example, we might know that flow ƒ1 and ƒ2 are using the same application protocol because they are visiting the same host address at the same port simultaneously. In this case, ƒ1 and ƒ2 shall be grouped into the same cluster ideally. Therefore, we describe these correlations in the form of pair-wise must-link constraints and incorporate them in the process of clustering. We have applied three constrained variants of the K-Means algorithm, which perform hard or soft constraint satisfaction and metric learning from constraints. A number of real-world traffic traces have been used to show the availability of constraints and to test the proposed approach. The experimental results indicate that by incorporating constraints in the course of clustering, the overall accuracy and cluster purity can be significantly improved.

Predicted packet padding for anonymous web browsing against traffic analysis attacks

Anonymous communication has become a hot research topic in order to meet the increasing demand for web privacy protection. However, there are few such systems which can provide high level anonymity for web browsing. The reason is the current dominant dummy packet padding method for anonymization against traffic analysis attacks. This method inherits huge delay and bandwidth waste, which inhibits its use for web browsing. In this paper, we propose a predicted packet padding strategy to replace the dummy packet padding method for anonymous web browsing systems. The proposed strategy mitigates delay and bandwidth waste significantly on average. We formulated the traffic analysis attack and defense problem, and defined a metric, cost coefficient of anonymization (CCA), to measure the performance of anonymization. We thoroughly analyzed the problem with the characteristics of web browsing and concluded that the proposed strategy is better than the current dummy packet padding strategy in theory. We have conducted extensive experiments on two real world data sets, and the results confirmed the advantage of the proposed method.

Semi-supervised and compound classification of network traffic

This paper presents a new semi-supervised method to effectively improve traffic classification performance when few supervised training data are available. Existing semi supervised methods label a large proportion of testing flows as unknown flows due to limited supervised information, which severely affects the classification performance. To address this problem, we propose to incorporate flow correlation into both training and testing stages. At the training stage, we make use of flow correlation to extend the supervised data set by automatically labeling unlabeled flows according to their correlation to the pre-labeled flows. Consequently, the traffic classifier has better performance due to the extended size and quality of the supervised data sets. At the testing stage, the correlated flows are identified and classified jointly by combining their individual predictions, so as to further boost the classification accuracy. The empirical study on the real-world network traffic shows that the proposed method outperforms the state-of-the-art flow statistical feature based classification methods.

Network traffic classification using correlation information

Traffic classification has wide applications in network management, from security monitoring to quality of service measurements. Recent research tends to apply machine learning techniques to flow statistical feature based classification methods. The nearest neighbor (NN)-based method has exhibited superior classification performance. It also has several important advantages, such as no requirements of training procedure, no risk of overfitting of parameters, and naturally being able to handle a huge number of classes. However, the performance of NN classifier can be severely affected if the size of training data is small. In this paper, we propose a novel nonparametric approach for traffic classification, which can improve the classification performance effectively by incorporating correlated information into the classification process. We analyze the new classification approach and its performance benefit from both theoretical and empirical perspectives. A large number of experiments are carried out on two real-world traffic data sets to validate the proposed approach. The results show the traffic classification performance can be improved significantly even under the extreme difficult circumstance of very few training samples.

Classifying network traffic in the big data era

With the arrival of Big Data Era, properly utilizing the power of big data is becoming increasingly essential for the strength and competitiveness of businesses and organizations. We are facing grand challenges from big data from different perspectives, such as processing, communication, security, and privacy. In this talk, we discuss the big data challenges in network traffic classification and our solutions to the challenges. The significance of the research lies in the fact that each year the network traffic increase exponentially on the current Internet. Traffic classification has wide applications in network management, from security monitoring to quality of service measurements. Recent research tends to apply machine-learning techniques to flow statistical feature based classification methods. In this talk, we propose a series of novel approaches for traffic classification, which can improve the classification performance effectively by incorporating correlated information into the classification process. We analyze the new classification approaches and their performance benefit from both theoretical and empirical perspectives. A large number of experiments are carried out on two real-world traffic datasets to validate the proposed approach. The results show the traffic classification performance can be improved significantly even under the extreme difficult circumstance of very few training samples. Our work has significant impact on security applications.