44 resultados para gune geografikoa


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[Antoine Guénée] Revue et augm. de plusieurs notes nouv. par [Léon M.] Desdouits

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Work attributed to Antoine Guénée in the Biographie universelle, ancienne et moderne, Paris, 1817, v. 19.

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Findings on growth regulating activities of the end-product of lipid peroxidation 4-hydroxy-2-nonenal (HNE), which acts as a “second messenger of free radicals”, overlapped with the development of antibodies specific for the aldehyde-protein adducts. These led to qualitative immunochemical determinations of the HNE presence in various pathophysiological processes and to the change of consideration of the aldehyde’s bioactivities from toxicity into cell signalling. Moreover, findings of the HNE-protein adduct in various organs under physiological circumstances support the concept of “oxidative homeostasis”, which implies that oxidative stress and lipid peroxidation are not only pathological but also physiological processes. Reactive aldehydes, at least HNE, could play important role in oxidative homeostasis, while complementary research approaches might reveal the relevance of the aldehydic-protein adducts as major biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis. Aiming to join efforts in such research activities researchers interacting through the International 4-Hydroxynonenal Club acting within the SFRR-International and through networking projects of the system of the European Cooperation in Science and Technology (COST) carried validation of the methods for lipid peroxidation and further developed the genuine 4-HNE-His ELISA founding quantitative and qualitative methods for detection of 4-HNE-His adducts as valuable tool to study oxidative stress and lipid peroxidation in cell cultures, various organs and tissues and eventually for human plasma and serum analyses [1]. Reference: 1. Weber, Daniela. Lidija, Milkovic. Measurement of HNE-protein adducts in human plasma and serum by ELISA—Comparison of two primary antibodies. Redox Biol. 2013. 226-233.

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Askatasunez zirkulatu eta erresiditzeko eskubidea europaren integrazio prozesuko lorpen handienetako bat izan da, Europar Batasunean (aurrerantzean EB) egunero milaka pertsonek gauzatzen duten eskubidea izanik. Zertan datza eskubide honek? Pertsona batek nazionala ez den beste estatu batera sartu edo irtetzeko edo bertan bere egoitza finkatzeko duen eskubidea da. Hala ere, eskubide hau oso zabala izan daiteke, hau egikari dezaketen subjektuak anitzak izan daitezkeelako edota eskubidea egikaritu daitekeen espazio geografikoa oso zabala delako, beste zenbaiten artean. Horregatik, beharrezkoa deritzogu atal bat eskubidearen marko guztia aipatu eta horren barnean aztertuko duguna zehaztera eskaintzea.