Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa

Fanconi anemia (FA) is a rare, genetically heterogeneous autosomal recessive disorder associated with progressive aplastic anemia, congenital abnormalities, and cancer. FA has a very high incidence in the Afrikaner population of South Africa, possibly due to a founder effect. Previously we observed allelic association between polymorphic markers flanking the FA group A gene (FANCA) and disease chromosomes in Afrikaners. We genotyped 26 FA families with microsatellite and single nucleotide polymorphic markers and detected five FANCA haplotypes. Mutation scanning of the FANCA gene revealed association of these haplotypes with four different mutations. The most common was an intragenic deletion of exons 12–31, accounting for 60% of FA chromosomes in 46 unrelated Afrikaner FA patients, while two other mutations accounted for an additional 20%. Screening for these mutations in the European populations ancestral to the Afrikaners detected one patient from the Western Ruhr region of Germany who was heterozygous for the major deletion. The mutation was associated with the same unique FANCA haplotype as in Afrikaner patients. Genealogical investigation of 12 Afrikaner families with FA revealed that all were descended from a French Huguenot couple who arrived at the Cape on June 5, 1688, whereas mutation analysis showed that the carriers of the major mutation were descendants of this same couple. The molecular and genealogical evidence is consistent with transmission of the major mutation to Western Germany and the Cape near the end of the 17th century, confirming the existence of a founder effect for FA in South Africa.

Founder-effect speciation theory: failure of experimental corroboration.

The theory of founder-effect speciation proposes that colonization by very few individuals of an empty habitat favors rapid genetic changes and the evolution of a new species. We report here the results obtained in a 10-year-long and large-scale experiment with Drosophila pseudoobscura designed to test the theory. In our experimental protocol, populations are established with variable numbers of very few individuals and allowed to expand greatly for several generations until conditions of severe competition for resources are reached and the population crashes. A few random survivors are then taken to start a new population expansion and thus initiate a new cycle of founding events, population flushes, and crashes. Our results provide no support for the theories proposing that new species are very likely to appear as by-products of founder events.

Emerging From the Shadows : the Life of Captain John (Deserontyou), Circa 1742-1811, Founder of the Bay of Quinte Mohawk Village

This thesis is a biographical examination of the life of Mohawk leader Deserontyou (Captain John) and covers the years from the 1730's up to, and briefly following, 1811. The social, economic and political position of the Mohawk people and Deserontyou's position within the Fort Hunter community prior to the Revolution are addressed first. The Revolutionary War years are then covered with emphasis placed on Deserontyou's military role, the unpleasant conditions at Lachine and the painful reality for the Mohawk people in the aftermath of Britain's defeat. The post-war settlement on the Bay of Quinte is then explored, including the difficulties that Deserontyou experienced with the land, with the British Government, and with his own people. The documents upon which this examination are based come from many primary collections including: The Draper Manuscripts, the Haldimand Papers, the Stuart Papers, Ontario Lands & Forest Survey Records, the Society for the Propagation of the Gospel in Foreign Parts, Episcopal Records, the Bell Papers, the File Collection, the Claus Papers and Indian Affairs Papers.

Founder, Academic, or Employee? A Nuanced Study of Career Choice Intentions

We add novel insights to the debate about why individuals choose to start their own firm by comparing entrepreneurial intentions to the intentions to work at a university as an academic and to be employed in a private firm. To model this more complex set of career choices, we examine novel multiplicative aspects of the theory of planned behavior (TPB) and test our hypotheses on survey data of 15,866 students from 13 European countries. Multinomial logistic regression analyses reveal how the different TPB elements influence career preferences and demonstrate the moderating effects of perceived controllability and desirability.

Russell H. Conwell, founder of the Institutional Church in America;

On cover: Russell H. Conwell: The man and the work.

A Life of John Colet, D.D. : dean of St. Paul's and founder of St. Paul's school ; with an appendix of some of his English writings /

Includes index.

Little Gidding and its founder; an account of the religious community established by Nicholas Ferrar in the XVIIth century.

Mode of access: Internet.

The life of Captain John Smith, the founder of Virginia.

Mode of access: Internet.

The life of Captain John Smith, the founder of Virginia /

Mode of access: Internet.

The correspondence of John Cleves Symmes : founder of the Miami Purchase, chiefly from the collection of Peter G. Thomson /

"Letters from Jonathan Dayton to John Cleves Symmes": p. 197-277.

The life of Sir Halliday Macartney, K. C. M. G., commander of Li Hung Chang's trained force in the Taeping rebellion, founder of the first Chinese arsenals, for thirty years councillor and secretary to the Chinese legation in London,

Mode of access: Internet.

The life & times of Sir Thomas Gresham...founder of the Royal exchange; including notices of many of his contemporaries...

T.-p. in red & black.

A wonderful story of old time Evangelism, being a simple account of the life and time of Jacob Albright, founder of the Evangelical Association, with the historical background and antecedents.

Bibliographical references.