IV Jornadas de Participaci??n Educativa : 17 al 19 de enero del 95

El objetivo es dar a conocer las ponencias presentadas en las que se intenta potenciar la participaci??n educativa y conseguir mejor calidad en la educaci??n. El contenido se dispone en varios bloques: la participaci??n en los Consejos Escolares, la participaci??n de los padres, de los alumnos, de los profesores y de la Comunidad educativa. Termina con una serie de conclusiones elaboradas por cada grupo de trabajo de los colectivos mencionados..

Control of Steroid 21-oic Acid Synthesis by Peroxisome Proliferator-activated Receptor and Role of the Hypothalamic-Pituitary-Adrenal Axis

A previous study identified the peroxisome proliferator-activated receptor alpha (PPARalpha) activation biomarkers 21-steroid carboxylic acids 11beta-hydroxy-3,20-dioxopregn-4-en-21-oic acid (HDOPA) and 11beta,20-dihydroxy-3-oxo-pregn-4-en-21-oic acid (DHOPA). In the present study, the molecular mechanism and the metabolic pathway of their production were determined. The PPARalpha-specific time-dependent increases in HDOPA and 20alpha-DHOPA paralleled the development of adrenal cortex hyperplasia, hypercortisolism, and spleen atrophy, which was attenuated in adrenalectomized mice. Wy-14,643 activation of PPARalpha induced hepatic FGF21, which caused increased neuropeptide Y and agouti-related protein mRNAs in the hypothalamus, stimulation of the agouti-related protein/neuropeptide Y neurons, and activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in increased adrenal cortex hyperplasia and corticosterone production, revealing a link between PPARalpha and the HPA axis in controlling energy homeostasis and immune regulation. Corticosterone was demonstrated as the precursor of 21-carboxylic acids both in vivo and in vitro. Under PPARalpha activation, the classic reductive metabolic pathway of corticosterone was suppressed, whereas an alternative oxidative pathway was uncovered that leads to the sequential oxidation on carbon 21 resulting in HDOPA. The latter was then reduced to the end product 20alpha-DHOPA. Hepatic cytochromes P450, aldehyde dehydrogenase (ALDH3A2), and 21-hydroxysteroid dehydrogenase (AKR1C18) were found to be involved in this pathway. Activation of PPARalpha resulted in the induction of Aldh3a2 and Akr1c18, both of which were confirmed as target genes through introduction of promoter luciferase reporter constructs into mouse livers in vivo. This study underscores the power of mass spectrometry-based metabolomics combined with genomic and physiologic analyses in identifying downstream metabolic biomarkers and the corresponding upstream molecular mechanisms.

Wahre vnd eigentliche Abcontrafeihung, sambt gewissem Bericht des grossen Schadens vnd Niederlag der Hochfürstl. Durchleucht. Ertzhertzogen Leopoldi Armeen, sampt deroselben Abzug vor Hagenaw : vnd was sich sonst ferner zwischen der Leopoldischen vnd Manßfeldischen Armada, den 16. 17. 18. 19. 20. 21. vnd 22. May ... dieses instehenden 1622. Jahres eigentlich verlauffen vnd zugetragen hat

Bibliograph. Nachweis: VD 17 39:123977B; Harms, Dt. Illustr. Flugbl., II, 198; Paas P-946

Ley de timbres, vigente desde el 10. de enero de 1905. Edición arreglada por el Ministerio de Hacienda, de acuerdo con los Decretos legislativos de 21, 17 y 19 de octubre de 1899, 1903, y 1904 respectivamente.

Mode of access: Internet.

New economic realities [microform] : the role of women entrepreneurs : hearings before the Committee on Small Business, House of Representatives, One Hundredth Congress, second session, Washington, DC, April 26 and 27; May 10, 11, 17, and 19, 1988.

"Serial no. 100-53."

Examen público á que se presentan los caballeros alumnos del Real Seminario de Nobles de esta Córte dirigido por la Compañía de Jesús en los días 17, 18, 19, 20, 22 y 23 de diciembre del presente año de 1828

Descripción basada en ejemplar del CCPB.

National Conference on Increasing Highway Engineering Productivity, Somerset Hotel, Boston, Massachusetts, September 17-18-19, 1957.

Sponsored by Bureau of public roads, U.S. Department of Commerce, American Association of State Highway Officials, Association of Highway Officials of the North Atlantic States, Massachusetts Department of Public Works, Massachusetts Institute of Technology.