Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System

Purpose. To evaluate the contribution of the ocular risk factors in the conversion of the fellow eye of patients with unilateral exudative AMD, using a novel semiautomated grading system. Materials and Methods. Single-center, retrospective study including 89 consecutive patients with unilateral exudative AMD and ≥3 years of followup. Baseline color fundus photographs were graded using an innovative grading software, RetmarkerAMD (Critical Health SA). Results. The follow-up period was 60.9 ± 31.3 months. The occurrence of CNV was confirmed in 42 eyes (47.2%). The cumulative incidence of CNV was 23.6% at 2 years, 33.7% at 3 years, 39.3% at 5 years, and 47.2% at 10 years, with a mean annual incidence of 12.0% (95% CI = 0.088-0.162). The absolute number of drusen in the central 1000 and 3000  μ m (P < 0.05) and the absolute number of drusen ≥125 µm in the central 3000 and 6000 µm (P < 0.05) proved to be significant risk factors for CNV. Conclusion. The use of quantitative variables in the determination of the OR of developing CNV allowed the establishment of significant risk factors for neovascularization. The long follow-up period and the innovative methodology reinforce the value of our results. This trial is registered with ClinicalTrials.gov NCT00801541.

RETINAL ANGIOMATOUS PROLIFERATION: A Quantitative Analysis of the Fundoscopic Features of the Fellow Eye

PURPOSE: To quantitatively analyze and compare the fundoscopic features between fellow eyes of retinal angiomatous proliferation and typical exudative age-related macular degeneration and to identify possible predictors of neovascularization. METHODS: Retrospective case-control study. Seventy-nine fellow eyes of unilateral retinal angiomatous proliferation (n = 40) and typical exudative age-related macular degeneration (n = 39) were included. Fundoscopic features of the fellow eyes were assessed using digital color fundus photographs taken at the time of diagnosis of neovascularization in the first affected eye. Grading was performed by two independent graders using RetmarkerAMD, a computer-assisted grading software based on the International Classification and Grading System for age-related macular degeneration. RESULTS: Baseline total number and area (square micrometers) of drusen in the central 1,000, 3,000, and 6,000 μm were considerably inferior in the fellow eyes of retinal angiomatous proliferation, with statistically significant differences (P < 0.05) observed in virtually every location (1,000, 3,000, and 6,000 μm). A soft drusen (≥125 μm) area >510,196 μm2 in the central 6,000 μm was associated with an increased risk of neovascularization (hazard ratio, 4.35; 95% confidence interval [1.56-12.15]; P = 0.005). CONCLUSION: Baseline fundoscopic features of the fellow eye differ significantly between retinal angiomatous proliferation and typical exudative age-related macular degeneration. A large area (>510,196 μm2) of soft drusen in the central 6,000 μm confers a significantly higher risk of neovascularization and should be considered as a phenotypic risk factor.

Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System

Purpose. To evaluate the contribution of the ocular risk factors in the conversion of the fellow eye of patients with unilateral exudative AMD, using a novel semiautomated grading system. Materials and Methods. Single-center, retrospective study including 89 consecutive patients with unilateral exudative AMD and ≥3 years of followup. Baseline color fundus photographs were graded using an innovative grading software, RetmarkerAMD (Critical Health SA). Results. The follow-up period was 60.9 ± 31.3 months. The occurrence of CNV was confirmed in 42 eyes (47.2%). The cumulative incidence of CNV was 23.6% at 2 years, 33.7% at 3 years, 39.3% at 5 years, and 47.2% at 10 years, with a mean annual incidence of 12.0% (95% CI = 0.088-0.162). The absolute number of drusen in the central 1000 and 3000  μ m (P < 0.05) and the absolute number of drusen ≥125 µm in the central 3000 and 6000 µm (P < 0.05) proved to be significant risk factors for CNV. Conclusion. The use of quantitative variables in the determination of the OR of developing CNV allowed the establishment of significant risk factors for neovascularization. The long follow-up period and the innovative methodology reinforce the value of our results. This trial is registered with ClinicalTrials.gov NCT00801541.

RETINAL ANGIOMATOUS PROLIFERATION: A Quantitative Analysis of the Fundoscopic Features of the Fellow Eye

PURPOSE: To quantitatively analyze and compare the fundoscopic features between fellow eyes of retinal angiomatous proliferation and typical exudative age-related macular degeneration and to identify possible predictors of neovascularization. METHODS: Retrospective case-control study. Seventy-nine fellow eyes of unilateral retinal angiomatous proliferation (n = 40) and typical exudative age-related macular degeneration (n = 39) were included. Fundoscopic features of the fellow eyes were assessed using digital color fundus photographs taken at the time of diagnosis of neovascularization in the first affected eye. Grading was performed by two independent graders using RetmarkerAMD, a computer-assisted grading software based on the International Classification and Grading System for age-related macular degeneration. RESULTS: Baseline total number and area (square micrometers) of drusen in the central 1,000, 3,000, and 6,000 μm were considerably inferior in the fellow eyes of retinal angiomatous proliferation, with statistically significant differences (P < 0.05) observed in virtually every location (1,000, 3,000, and 6,000 μm). A soft drusen (≥125 μm) area >510,196 μm2 in the central 6,000 μm was associated with an increased risk of neovascularization (hazard ratio, 4.35; 95% confidence interval [1.56-12.15]; P = 0.005). CONCLUSION: Baseline fundoscopic features of the fellow eye differ significantly between retinal angiomatous proliferation and typical exudative age-related macular degeneration. A large area (>510,196 μm2) of soft drusen in the central 6,000 μm confers a significantly higher risk of neovascularization and should be considered as a phenotypic risk factor.

On the brink of madness: Leituras do tema da loucura na obra pré-heteronímica de Fernando Pessoa

O tema da loucura na obra pessoana tem sido objecto de várias aproximações interpretativas, decorrentes da multiplicidade de textos que fazem eco do fenómeno e da sua persistência enquanto topos ao longo de praticamente toda a sua produção. Na sua acepção literal, manteve constantes interferências com a dimensão empírica do autor sobretudo quando sustentadas na contingência de certos textos basilares, os quais têm vindo a ser questionados quanto ao seu valor estritamente testemunhal. Como fenómeno desde cedo relacionado com a criação artística, a loucura surge neste estudo não apenas na representatividade da condição distintiva do sujeito criador mas ainda como figuração da contingência que envolve qualquer acto criativo que tome a linguagem na sua dimensão essencialmente metafórica e ambígua. Neste sentido, o presente trabalho pretende a abertura de várias vias de leitura do fenómeno através da análise crítica dos vocabulários relativos a diferentes âmbitos e concepções de loucura e a sua relação com o génio (capítulos I e II), focando o seu interesse no que diz respeito a alguma produção pessoana pré-heteronímica, nomeadamente Charles Robert Anon, Alexander Search (capítulo III) e Jean Seul de Méluret (capítulo IV), a que acrescentaremos o Primeiro Fausto (capítulo IV), de modo a conseguirmos estabelecer uma possível relação entre as primeiras experiências de alterização e a descoberta simultânea da irredutibilidade do discurso literário face a tentativas de literalização e de racionalização da linguagem, defendidas por outros modelos (paradigma biologista). A identificação da ambiguidade e da ironia nas suas mais variadas acepções como componentes essenciais da aprendizagem do valor contingente do processo de criação contribuirá tanto para a definição da autonomização da literatura como para a redescrição moderna do sujeito criador, paradoxalmente investido do pathos criativo anunciado no Romantismo e confrontando-se com os seus limites, que corresponderão aos da própria linguagem, situação de crise de que a figuração do louco lúcido será um dos tópicos mais produtivos. ABSTRACT: The theme of madness in the Pessoa work has been the subject of several interpretive approaches, from the multiplicity of texts that echo the phenomenon and its persistence as a topos priority over virtually all its production. ln its physiological sense, remained constant interference with the empirical dimension of the author when sustained in the contingency of certain basic texts that have been questioned as to their strictly testimonial value. As early phenomenon associated with artistic creation, the madness in this study is not only representative in the distinctive condition of the subject creator but also as the contingency figuration involving any creative act to take the language mainly in its essential metaphorical and ambiguous dimension. Accordingly, this work intends to open several analysis manners of the phenomenon through critical analysis of vocabularies for different areas and concepts of madness and its special relationship with the genius (Chapters I and II), focusing its interest in respect to some of the previous-heteronomy Pessoa production, including Charles Robert Anon, Alexander Search (Chapter III) and Jean Seul de Méluret (Chapter IV), and the Primeiro Fausto (Chapter IV), among others, to establish a possible relationship between changing early experiences and the discovery simultaneous literary discourse of irreducibility in the face of the attempts of literacy and the rationalization of language defended by other models (biologist paradigm). The identification of the ambiguity and irony in its many different meanings as essential components of learning the contingent value of the creation process which will contribute to the definition of empowerment in the literature as to the redescription of the modem subject creator that paradoxically had the creative pathos announced in Romanticism and from the confrontation with its limits, which will correspond to the language itself, the crisis situation from which the mad-lucid figuration will be one of the most productive topics.

Efeito da temperatura no desenvovimento in vitro de pimenteira-do-reino (Piper nigrum L.).

A pimenteira-do-reino (Piper nigrum L.) é uma importante especiaria usada em diversas industriais e é um dos principais produtos agrícolas da pauta de exportações do estado do Pará. A propagação vegetativa, método comercial de produção de mudas de pimenteira-do-reino, se realizada a partir de plantas matrizes infectadas com vírus, promove à degenerescência da planta e prejuízos na produtividade. A temperatura elevada é uma alternativa para a limpeza clonal via micropropagação. O objetivo desse estudo foi verificar a termotolerância dos brotos cultivadas in vitro visando a limpeza clonal. Os explantes (gemas apicais e laterais) foram cultivados in vitro em experimentos preliminares de termotolerância. As temperaturas usadas foram: 32 ºC, 33 ºC, 34 ºC, 36 ºC e 38 ºC, com fotoperíodo de 16 h. luz. Foram avaliados: taxa de oxidação e desenvolvimento de novas folhas. Explantes de pimenteira-do-reino permaneceram incubadas em câmaras do tipo BOD com ajuste de temperatura por 30 dias em cada temperatura. À temperatura de 38 ºC ocorreu elevada taxa de oxidação dos explantes e sem desenvolvimento de brotos enquanto à temperatura de 32 ºC, os explantes diferenciaram in vitro com novas brotações e folhas, sem oxidação. A temperatura dos explantes in vitro influencia diretamente da taxa de sobrevivência e desenvolvimento de pimenteira-do-reino micropropagadas, sendo sugerida a temperatura de 32 ºC para auxiliar a limpeza clonal no processo de micropropagação.