CDKN2A promoter hypermethylation in astrocytomas is associated with age and sex

CDKN2A promoter hypermethylation has been widely related to many cancers. In astrocytomas, although CDKN2A (p16INK4A protein) is often inactivated, there are still some controversial issues regarding the mechanism by which this alteration occurs. Thus, we analyzed a series of astrocytomas to assess the association between CDKN2A expression and methylation of grade I-IV tumors (WHO) and clinicopathological parameters. DNA extracted from formalin-fixed paraffin-embedded material of 93 astrocytic tumors was available for CDKN2A promoter methylation analysis and p16INK4A expression by methylation-specific PCR and immunohistochemistry, respectively. A strong negative correlation between nuclear and cytoplasmic immunostaining and CDKN2A promoter methylation was found. Additionally, a significant negative correlation between CDKN2A promoter methylation and age was observed; also, female patients had statistically more CDKN2A methylated promoters (p=0.036) than men. In conclusion, CDKN2A inactivation by promoter methylation is a frequent event in astrocytomas and it is related to the age and sex of patients. © 2013 Surgical Associates Ltd.

Violência sexual infantil: compreensão de professoras sobre conceito e prevenção

Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

Entre la pureza y la perversión : Construcciones médico-jurídicas sobre los delitos sexuales en menores en la Argentina entre 1860 y 1880

El trabajo tiene como objetivo indagar respecto de algunas de las construcciones que peritos médicos y juristas compartían o discutían respecto de qué define al niño, al joven y al menor (tanto varón como mujer) así como las ideas que circularon en el ámbito de la justicia respecto de la sexualidad de aquellos, en el contexto específico de los delitos sexuales que los tuvieran como víctimas en un amplio marco temporal que va de 1850 a 1890 en la Provincia de Buenos Aires. He decidido trabajar en forma simultánea ambos grupos de profesionales por cuanto comparten al mismo tiempo una base educativa común, teniendo formación universitaria, y un conjunto de lecturas similar: escritos ingleses sobre el tratamiento de las pruebas, manuales franceses sobre medicina legal, y las teorías nuevas que circulaban en Europa sobre la psiquiatría y la psicopatología sexual. Para el trabajo utilizo expedientes judiciales relevados en el Archivo Judicial de la Corte Suprema (AJCS) y en el Archivo Histórico de la Provincia de Buenos Aires (AHPBA) buscando mostrar como los legistas involucrados dejan constancia de imágenes cristalizadas sobre cómo debe ser y quién es una victima

Entre la pureza y la perversión : Construcciones médico-jurídicas sobre los delitos sexuales en menores en la Argentina entre 1860 y 1880

El trabajo tiene como objetivo indagar respecto de algunas de las construcciones que peritos médicos y juristas compartían o discutían respecto de qué define al niño, al joven y al menor (tanto varón como mujer) así como las ideas que circularon en el ámbito de la justicia respecto de la sexualidad de aquellos, en el contexto específico de los delitos sexuales que los tuvieran como víctimas en un amplio marco temporal que va de 1850 a 1890 en la Provincia de Buenos Aires. He decidido trabajar en forma simultánea ambos grupos de profesionales por cuanto comparten al mismo tiempo una base educativa común, teniendo formación universitaria, y un conjunto de lecturas similar: escritos ingleses sobre el tratamiento de las pruebas, manuales franceses sobre medicina legal, y las teorías nuevas que circulaban en Europa sobre la psiquiatría y la psicopatología sexual. Para el trabajo utilizo expedientes judiciales relevados en el Archivo Judicial de la Corte Suprema (AJCS) y en el Archivo Histórico de la Provincia de Buenos Aires (AHPBA) buscando mostrar como los legistas involucrados dejan constancia de imágenes cristalizadas sobre cómo debe ser y quién es una victima

A guide to sex offender registration in Illinois /

On cover : Sex Offender Registration Program.

A guide to sex offender registration and community notification in Illinois : sex offender registration program.

Cover title.

Guide to sex offender registration in Illinois /

Mode of access: Internet.

Rape Study Committee : report to the House of Representatives and the 80th General Assembly of the State of Illinois.

Cover title.

Desistance from Sexual Offending: Do the Mainstream Theories Apply?

The literature on desistance from crime has become well established in recent years with strong bodies of evidence supporting the role of factors such as employment, relationships and identity change in this process. However, the relevance of this literature to individuals convicted of sexual crimes is not known as such individuals are almost always excluded from this research. This article presents the results from one of the first empirical studies on desistance from sexual offending based on 32 in-depth life story interviews with adult males previously convicted of child sex offences. In this analysis we explore the significance of work, the role of relationships, and changes in imagined selves in the self-identities of individuals successfully desisting from sexual offending. The findings provide support for all three factors in helping to sustain desistance from sex offending, but also suggest clear differences between desistance from sex offending and other types of crime in these regards.

Preschoolers’ Executive Control and Diurnal Cortisol as Mediators of the Relations of Prenatal Stress to Child Adjustment

Thesis (Ph.D.)--University of Washington, 2016-08

Sex, culpability, and the defence of provocation

The partial defence of provocation is one of the most controversial doctrines within the criminal law. It has now been abolished in a number of international jurisdictions. Addressing the trajectory of debates about reform of the provocation defence across different jurisdictions, Sex, Culpability and the Defence of Provocation considers the construction and representation of subjectivity and sexual difference in legal narrations of intimate partner homicide. Undeniably, the most vexing exculpatory cultural narrative of our times is that of a woman 'asking for it'. This book explores how the process of judgment in a criminal trial involves not only the drawing of inferences from the facts of a particular case, but also operates to deliver a narrative. Law, it is argued, constructs a narrative of how the female body incites male violence. And, pursuing an approach that is informed by socio-legal studies, literary theory and feminist theories of the body, Sex, Culpability and the Defence of Provocation considers how this narrative is constructed via a range of discursive practices that position woman as a threat to masculine norms of propriety and autonomy. Once we have a clear understanding of the significance of narrative in legal decision-making, we can then formulate textual strategies of resistance to the violence of law's victim-blaming narratives by rewriting them.

A guide to clarifying evidence in Australian child forensic interviews

Purpose – Interviewing victims of child sex abuse requires considerable care in order to minimise error. Due to children’s heightened suggestibility any question asked of a child could potentially incite error that could undermine the witness’s credibility. A focus group was conducted in order to facilitate the development of guidance for interviewers around the circumstances in which it is necessary to ask children follow-up questions in an interview. The paper aims to discuss these issues.

Design/methodology/approach – Seven Crown prosecutors representing every Australian state and territory (with the exception of one small state) were issued with 25 hypothetical narrative accounts of child abuse and asked to indicate what information, if any, required follow-up in the child’s narrative. Their responses and rationale for requiring following up in some cases and not others were discussed.

Findings – Thematic analysis revealed three recommendations to guide questioning: whether the case involved identification or recognition evidence; the presence of contextual features that may influence the witness’s memory, or that should trigger a particular line of questioning; and whether the information can or should be sought at a later stage by the trial prosecutor, rather than by the interviewer. Practical implications – The recommendations are discussed within the context of their implications for interviewing, that is, how each recommendation could be implemented in practice.

Originality/value – The present study extends prior literature by elucidating principles to guide decision making across interview topic areas. The need for such guidance is highlighted by research suggesting that topics such as offender identity, offence time and place, and witnesses are a source of overzealous questioning in interviews.

Contemporary comment : is it time for Australia to adopt Circles of Support and Accountability (COSA)?

Circles of Support and Accountability (COSA) - an innovative process for reintegrating child sex offenders into the community after a period of incarceration - have not yet been firmly established in any Australian jurisdiction. This is the case despite their widespread use in Canada, the United Kingdom. and parts of the United States of America, and despite a growing body of research evidence that demonstrates their efficacy in reducing recidivism among child sex offenders. This Contemporary Comment outlines the emergence of COSA and the existing evidence in support of COSA. It argues that COSA should be piloted in Australia.

UK church orders abuse inquiry

THE Church of England has ordered a formal independent investigation into the handling of child-sex allegations against a senior clergyman in Australia and Britain. Archbishop of York John Sentamu at the weekend commissioned the high-level inquiry into the alleged child sex abuse in the 1960s and 80s by the late Reverend Robert Waddington, and the church's response to complaints over the past 15 years. It comes as the head of Australia's Anglican Church, Archbishop Phillip Aspinall, flew to north Queensland to meet the region's bishop over the revelations, which centre on Waddington's stint as principal of St Barnabas boarding school at Ravenshoe, west of Cairns, and later as dean of Manchester.

Anglican Church knew clergyman Robert Waddington was a risk

AUSTRALIAN church officials knew of child-sex allegations in Britain against a senior clergymen when they pushed a victim into accepting a compensation payout on the basis that there was no evidence to back up his claims of abuse. Former Church of England investigator Ray Morris says he prepared a 2004 report about allegations in Britain and Australia - from the 1960s and 80s - against Robert Waddington. He sent it to north Queensland diocese officials, who were at the time involved in mediation with the Australian victim over his claims that he was abused weekly by Waddington between 1964 and 1968, who was headmaster of St Barnabas boarding school in Ravenshoe, southwest of Cairns.