New generation genomic platforms in investigation of complex diseases and BEN.

(Full text is available at http://www.manu.edu.mk/prilozi). New generation genomic platforms enable us to decipher the complex genetic basis of complex diseases and Balkan Endemic Nephropathy (BEN) at a high-throughput basis. They give valuable information about predisposing Single Nucleotide Polymorphisms (SNPs), Copy Number Variations (CNVs) or Loss of Heterozygosity (LOH) (using SNP-array) and about disease-causing mutations along the whole sequence of candidate-genes (using Next Generation Sequencing). This information could be used for screening of individuals in risk families and moving the main medicine stream to the prevention. They also might have an impact on more effective treatment. Here we discuss these genomic platforms and report some applications of SNP-array technology in a case with familial nephrotic syndrome. Key words: complex diseases, genome wide association studies, SNP, genomic arrays, next generation sequ-encing.

Król "Gebalim" w liście Chasdaja : studyum historyczne z.x.w.

napisał Teofil Emiol Modelski

First EURONEAR NEA discoveries from La Palma using the INT

Since 2006, the European Near Earth Asteroids Research (EURONEAR) project has been contributing to the research of near-Earth asteroids (NEAs) within a European network. One of the main aims is the amelioration of the orbits of NEAs, and starting in 2014 February we focus on the recovery of one-opposition NEAs using the Isaac Newton Telescope (INT) in La Palma in override mode. Part of this NEA recovery project, since 2014 June EURONEAR serendipitously started to discover and secure the first NEAs from La Palma and using the INT, thanks to the teamwork including amateurs and students who promptly reduce the data, report discoveries and secure new objects recovered with the INT and few other telescopes from the EURONEAR network. Five NEAs were discovered with the INT, including 2014 LU14, 2014 NL52 (one very fast rotator), 2014 OL339 (the fourth known Earth quasi-satellite), 2014 SG143 (a quite large NEA), and 2014 VP. Another very fast moving NEA was discovered but was unfortunately lost due to lack of follow-up time. Additionally, another 14 NEA candidates were identified based on two models, all being rapidly followed-up using the INT and another 11 telescopes within the EURONEAR network. They include one object discovered by Pan-STARRS, two Mars crossers, two Hungarias, one Jupiter trojan, and other few inner main belt asteroids (MBAs). Using the INT and Sierra Nevada 1.5 m for photometry, then the Gran Telescopio de Canarias for spectroscopy, we derived the very rapid rotation of 2014 NL52, then its albedo, magnitude, size, and its spectral class. Based on the total sky coverage in dark conditions, we evaluate the actual survey discovery rate using 2-m class telescopes. One NEA is possible to be discovered randomly within minimum 2.8 deg2 and maximum 5.5 deg2. These findings update our past statistics, being based on double sky coverage and taking into account the recent increase in discovery.

Nauka polska, jej potrzeby, organizacja i rozwöj. Rocznik Kasy pomocy dla osób pracujacych na polu naukowym imienia doktora Józefa Mianowskiego.

Subtitle varies.

My return to the Church of Christ.

Mode of access: Internet.

Wirydarz poetycki /

Mode of access: Internet.

Application of mint and cinamon against Fusarium disease of winter wheat

In our study the application of mint species (spearmint, peppermint ‘Mitcham’ and peppermint ‘Mexian’) and cinnamon was investigated against Fusarium head blight of winter wheat in vitro and in vivo. The effect of crude drugs and the aqueous extract of mint, and the effect of essential oils of mint and cinnamon on mycelial growth were evaluated in lab. On artificial media the crude drug showed higher inhibition than aqueous plant extracts. Cinnamon and spearmint oils e.ectively inhibited mycelia growth. In field trial artificially inoculated winter wheat was treated with the in vitro effective oils under small-plot conditions. The disease incidence was most inhibited by cinnamon oil, applied curative. According to our results the essential oil of cinnamon can be an appropriate candidate for the research of alternative disease control.

On the political dimension of political science – a few words about political dimension as the final judgment and reasoning

The subject of the text is the issue of the "political", which is defined as the nature and level of the final judgment and ultimate reasoning. The issues of this kind of the "political" has been attempted to distinguish in political sciences. The text focuses on: (1) the scientist as an agent for the final judgment and reasoning, (2) the subject of study of political science, (3) "theoretical strategies" in the science of politics. The latter problem has been discussed mainly on the example of Polish political science. Discussed were among others: (1) "the dilemma of scale", (2) limited operational capacity (methodological and theoretical), (3) aesthetic imagery of political life, (4) structural ignorance in the field of ontology, epistemology and methodology.

Czas wolny, turystyka i rekreacja osób niesłyszących w Polsce - zarys specyfiki problemu

This study brings closer the problems of a selected group with a handicap – deaf people for whom the main mode of communication is the Polish Sign Language. The subject of studies is leisure time, how it is spent by them both everyday and during vacation. The book presents a survey of literature, good practice and also results of the author’s own studies conducted in the years 2004-2010, concerning problems of tourism and recreation of the deaf. In the years 2008-2010 studies were conducted within the research project financed by Ministerstwo Nauki i Szkolnictwa Wyższego (the Ministry of Science and Higher Education). One of the results of work on this project are multimedia programmes – tourist guides: SITur and SITex containing a translator of the Polish Sign Language.

Polityka Turcji wobec mniejszości muzułmańskich i niemuzułmańskich w świetle standardów Unii Europejskiej

Wydział Nauk Politycznych i Dziennikarstwa

Ocena humanistyki w świetle wyzwań Narodowego Programu Rozwoju Humanistyki

Za lekturę i uwagi do pierwszej wersji tekstu dziękuję Anecie Drabek i Ewie Rozkosz.

Plejotropowe działanie neuropeptydów allatostatynowych w regulacji procesów fizjologicznych u chrząszczy

Wydział Biologii

Historiografia dziejów najnowszych po 1989 roku wobec innych nauk społecznych (na przykładzie psychologii). Refleksja metodologiczna i postulaty badawcze

Celem artykułu jest krytyczna rekonstrukcja stanu refleksji metodologicznej w kwestii interdyscyplinarnej współpracy między naukami historycznymi i psychoiogicznymi.

Raport z analizy bibliometrycznej. „Pamiętnik Literacki” i „Diametros – An Online Journal of Philosophy”

Prace realizowane w projekcie "Współczesna polska humanistyka wobec wyzwań naukometrii ze środków Narodowego Programu Rozwoju Humanistyki", numer decyzji 0057/NPHR3/H11/82/2014