990 resultados para Worcester, Edward Somerset, Marquis of, 1601-1667.


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Half-title: Delineations of ... Somerset, and of the Mendip caverns.

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Mode of access: Internet.

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Works, and Appendix of attributed works: v. 2, p. 269-541.

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Anticardiolipin (aCL) autoantibodies are associated with thrombosis, recurrent fetal loss, and thrombocytopenia. Only aCL found in autoimmune disease require the participation of the phospholipid binding plasma protein β2 glycoprotein I (β2GPI) for antibody binding and now are called anti-β2GPI. The antigenic specificity of aCL affinity purified from 11 patients with high titers was evaluated in an effort to better understand the pathophysiology associated with aCL. Seven different recombinant domain-deleted mutants of human β2GPI, and full length human β2GPI (wild-type), were used in competition assays to inhibit the autoantibodies from binding to immobilized wild-type β2GPI. Only those domain-deleted mutants that contained domain 1 inhibited the binding to immobilized wild-type β2GPI from all of the patients. The domain-deleted mutants that contained domain 1 inhibited all aCL in a similar but not identical pattern, suggesting that these aCL recognize a similar, but distinguishable, epitope(s) present on domain 1.

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"The article is attributed to the pen of Edward S. Gould." cf. p. [2]

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On spine: The works of Edward FitzGerald.

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Mode of access: Internet.