The phylogeography of trypanosomes from South American alligatorids and African crocodilids is consistent with the geological history of South American river basins and the transoceanic dispersal of Crocodylus at the Miocene

Background: Little is known about the diversity, phylogenetic relationships, and biogeography of trypanosomes infecting non-mammalian hosts. In this study, we investigated the influence of host species and biogeography on shaping the genetic diversity, phylogenetic relationship, and distribution of trypanosomes from South American alligatorids and African crocodilids. Methods: Small Subunit rRNA (SSU rRNA) and glycosomal Glyceraldehyde Phosphate Dehydrogenase (gGAPDH) genes were employed for phylogenetic inferences. Trypanosomes from crocodilians were obtained by haemoculturing. Growth behaviour, morphology, and ultrastructural features complement the molecular description of two new species strongly supported by phylogenetic analyses. Results: The inferred phylogenies disclosed a strongly supported crocodilian-restricted clade comprising three subclades. The subclade T. grayi comprised the African Trypanosoma grayi from Crocodylus niloticus and tsetse flies. The subclade T. ralphi comprised alligatorid trypanosomes represented by Trypanosoma ralphi n. sp. From Melanosuchus niger, Caiman crocodilus and Caiman yacare from Brazilian river basins. T. grayi and T. ralphi were sister subclades. The basal subclade T. terena comprised alligatorid trypanosomes represented by Trypanosoma terena n. sp. from Ca. yacare sharing hosts and basins with the distantly genetic related T. ralphi. This subclade also included the trypanosome from Ca. crocodilus from the Orinoco basin in Venezuela and, unexpectedly, a trypanosome from the African crocodilian Osteolaemus tetraspis. Conclusion: The close relationship between South American and African trypanosomes is consistent with paleontological evidence of recent transoceanic dispersal of Crocodylus at the Miocene/Pliocene boundaries (4–5 mya), and host-switching of trypanosomes throughout the geological configuration of South American hydrographical basins shaping the evolutionary histories of the crocodilians and their trypanosomes.

Towards a new design of South American integration? Jean Monnet/Robert Schuman Paper Series, Special Issue January 2013

The design of South American integration is becoming different. This has been quite common in the trajectory of over six decades of initiatives aimed at generating institutional frameworks to facilitate regional integration. However, even when it has become apparent that the previous design is undergoing a new process of change, it would be difficult to predict for how long the one that is beginning to take shape will remain in effect. The experience of recent decades suggests great caution in forecasts that are optimistic about any eventual longevity. Several factors are contributing to this redesign. Some are external to the region while others are endogenous. The combination of these factors will influence the future design of South American integration. If past lessons are correctly capitalized and certain advantage is derived from the leeway provided by a decentralized international system with multiple options, we can anticipate that what will predominate in the region will be multidimensional integration agreements (with political and economic objectives at the same time) and with cross-memberships and commitments. If this were the case, the actual impact on regional governance, social and productive integration and the competitive insertion at a global scale will depend largely on the following factors: the quality and sustainability of the strategy for development and global and regional insertion of each country; the combination of a reasonable degree of flexibility and predictability in the commitments made and their corresponding ground rule, and the density of the network of cross-interests that can be achieved as a result of the respective regional integration agreements, reflected in multiple transnational social and production networks.

The industrial censuses of the American Nations,

Includes bibliographies.

Statutes of the Union of South Africa = Wetten van die Unie van Zuid-Afrika.

Issues for <1948>-1960 have title in Afrikaans: Wette van die Unie van Suid-Afrika.

Minutes of evidence taken in the Union of South Africa in 1914.

At head of title: Royal Commission on the Natural Resources, Trade, and Legislation of certain portions of His Majesty's Dominions.

Handbook of South American Indians.

Includes bibliographies.

Census of the European or white races of the Union of South Africa, 1918 = Census van de Europees of blanke bevolking van de Unie van Zuid-Afrika, 1918.

Prepared by the Office of Census and Statistics, South Africa.

Proposed constitution for one national industrial union of all American seamen, respectfully submitted for the consideration of the membership of the following organizations: Pacific Coast Marine Firemen, Oilers, Water-tenders & Wipers Association; Sailors'Union of the Pacific; Marine Cooks & Stewards' Association of the Pacific Coast; Inlandboatmen's Union of the Pacific; and, National Maritime Union of America.

Proposed constitution of the United Seamen of America.

The Federal Convention and the formation of the Union of the American States.

"The Federal Convention: Madison's notes of debates": p. [65]-344.

The agricultural journal of the Union of South Africa.

Mode of access: Internet.

TAFRO Syndrome in a Patient of South-American Descent

A 31-year-old Caucasian woman of South-American descent was diagnosed with a variant of multicentric Castleman disease (MCD) that has been reported in Japan as Castleman-Kojima disease. This is a systemic inflammatory disorder known as TAFRO Syndrome which includes thrombocytopenia, polyserositis (ascites/pleural effusion), microcytic anemia, myelofibrosis, fever, renal dysfunction and organomegaly, with immunologic disorder, polyclonal hypergammaglobulinemia, and elevated levels of interleukin-6 (IL-6) and the vascular endothelial growth factor present in serum and/or effusions. Optimal therapies are not well established. The patient was treated with methylprednisolone and rituximab. Following the start of treatment, the patient has been asymptomatic for over 8 months.

La política exterior brasilera como eje del nuevo proceso de integración: la Unión de Naciones Suramericanas (2004-2008)

La Unión de Naciones Suramericanas (UNASUR) fue creada en el año 2008 después de un largo proceso impulsado en gran medida por Brasil. Esta monografía analizará los intereses que promueven esta propuesta y los beneficios que la misma trae al país, por medio de un análisis de su política exterior.

La estrategia exterior de seguridad y defensa de Brasil (2001-2008) como elemento de proyección hacia Suramérica. Caso de estudio : promoción del Consejo Suramericano de Defensa

La estrategia exterior de seguridad y defensa de Brasil es el elemento por excelencia de proyección regional de este país. A través de la utilización de Instituciones Internacionales y regionales, como la Unión de Naciones Suramericanas y el Consejo Suramericano de Defensa, Brasil logra configurarse como un actor emergente con grandes posibilidades de transformar la balanza de poder del Sistema Internacional.

El rol del Centro de Estudios Estratégicos de Defensa de la Unión de Naciones Suramericanas en la formación de un pensamiento estratégico regional

El presente estudio de caso analiza los aportes del Centro de Estudios Estratégicos de Defensa (CEED) de la Unión de Naciones Suramericanas (Unasur) en la formación de un pensamiento estratégico regional. Cuatro años han transcurrido desde la creación de dicho Centro, por lo que resulta pertinente estudiar sus principales logros y los aportes realizados al Consejo de Defensa Suramericano (CDS) para la formación de un pensamiento estratégico regional en materia de seguridad y defensa.

El surgimiento de una nueva diplomacia regional en salud en tiempos posteriores al neoliberalismo: el caso de UNASUR Salud (Otros Temas)

Since the creation of Union of South American Nations (UNASUR), health policies have become a strategic element in dealing with the impact of neoliberal policies in the region. The aim of this paper is: first, to describe the social, political and economic processes that explain the emergence of UNASUR and its focus on social policy through health care, and second, how through UNASUR Health, health became the engine behind a new kind of health diplomacy. This article hopes to contribute to the debate on the new forms of health diplomacy and the role of regional organizations concentrating on health policies as a centrepiece of their regional integration efforts and the reduction of social inequalities.