Process mining manifesto

Process mining techniques are able to extract knowledge from event logs commonly available in today’s information systems. These techniques provide new means to discover, monitor, and improve processes in a variety of application domains. There are two main drivers for the growing interest in process mining. On the one hand, more and more events are being recorded, thus, providing detailed information about the history of processes. On the other hand, there is a need to improve and support business processes in competitive and rapidly changing environments. This manifesto is created by the IEEE Task Force on Process Mining and aims to promote the topic of process mining. Moreover, by defining a set of guiding principles and listing important challenges, this manifesto hopes to serve as a guide for software developers, scientists, consultants, business managers, and end-users. The goal is to increase the maturity of process mining as a new tool to improve the (re)design, control, and support of operational business processes.

SHOX gene is expressed in vertebral body growth plates in idiopathic and congenital scoliosis : implications for the etiology of scoliosis in Turner Syndrome

Reduced SHOX gene expression has been demonstrated to be associated with all skeletal abnormalities in Turner syndrome, other than scoliosis (and kyphosis). There is evidence to suggest that Turner syndrome scoliosis is clinically and radiologically similar to idiopathic scoliosis, although the phenotypes are dissimilar. This pilot gene expression study used relative quantitative real-time PCR (qRT-PCR) of the SHOX (short stature on X) gene to determine whether it is expressed in vertebral body growth plates in idiopathic and congenital scoliosis. After vertebral growth plate dissection, tissue was examined histologically and RNA was extracted and its integrity was assessed using a Bio-Spec Mini, NanoDrop ND-1000 spectrophotometer and standard denaturing gel electrophoresis. Following cDNA synthesis, gene-specific optimization in a Corbett RotorGene 6000 real-time cycler was followed by qRT-PCR of vertebral tissue. Histological examination of vertebral samples confirmed that only growth plate was analyzed for gene expression. Cycling and melt curves were resolved in triplicate for all samples. SHOX abundance was demonstrated in congenital and idiopathic scoliosis vertebral body growth plates. SHOX expression was 11-fold greater in idiopathic compared to congenital (n = 3) scoliosis (p = 0.027). This study confirmed that SHOX was expressed in vertebral body growth plates, which implies that its expression may also be associated with the scoliosis (and kyphosis) of Turner syndrome. SHOX expression is reduced in Turner syndrome (short stature). In this study, increased SHOX expression was demonstrated in idiopathic scoliosis (tall stature) and congenital scoliosis.

An examination of how the military, the conservative press and ministerialist politicians generated support within Queensland for the war in South Africa in 1899 and 1900

This thesis examines the role of conservative newspaper proprietors and editors to generate support for war against the Boers in South Africa. The thesis utilises Rune Ottosen's theoretical model concerning newspapers creating a pro-war mentality, and S.E. Finer's theory on the influences of the military on civilian Government. The pivotal supportive roles of Governor Lamington and Premiers Dickson and Philp and the oppositional role of Premier Dawson are also examined.

A QUM partnership approach to regulating biosimilars in Australia

Despite the realisation of the potential implications from biosimilars is relatively recent, much has already been written about raising the awareness of differences between biosimilars and originating/ reference listed (innovator) pharmaceuticals. The European Medicines Agency has led the global charge in regulating biosimilars. Regardless of sufficient similarities across international regulations, differences do exist across jurisdictions. The consideration of regulating biosimilars demands a congruent approach across all stages: pre-registration (Australian copyright protection, patent, international obligations), registration (confidential information, international regulators, safety and efficacy), post-registration (Pharmaceutical Benefit Scheme, prescriber and dispenser awareness). Our National Medicines Policy could provide the necessary congruent framework and function for national and international regulation of biosimilars. The Policy concedes that pharmaceuticals will be affected by financial policies and trade considerations, international treaty obligations, industrial policies, education policies and the need for public-private partnerships.

The scholarship of Jonathan Silin: a reading through the lens of sexuality

While Jonathan Silin's ideas have challenged early childhood educators to think seriously about the relationship between developmentalism and revisioning early education, they have done much more than this. They also challenge us to know who we are and how our identities might be enacted in our teacher-selves, whether in the classroom with young children, teacher education students or engaging professionally with teachers. In doing so he shows how to resist injustice and unmasks ways in which institutions function in society to marginalise and exclude.

Aus meinem Leben 1899-1918

The memoir was written between 1899 and 1918. Family history going back to the early 18th century. Recollection of the author's childhood in Hildesheim. Moritz was the youngest child of Joseph and Bena Guedemann. Early death of his father in 1847. Moritz attended the Jewish elementary school prior to the age of five. In 1843 he was enrolled in the episcopal "Josephinum Gymnasium", where he was the only Jewish student in the entire school. He had friendly relationships with students and teachers and was not confronted with antisemitism during his school years. Moritz Guedemann graduated in 1853 and enrolled in the newly established Jewish Theological Seminary in Breslau. Description of teachers and colleagues in the seminary. Doctorate in 1858 and continuation of rabbinic studies. Occasional invitation to preach at the high holidays in Berlin, where Moritz got acquainted with the famous rabbi Dr. Michael Sachs. Position as a rabbi in Magdeburg in 1862. Small publications of studies in Jewish history. Engagement with Fanny Spiegel. In 1863 Moritz and Fanny Guedemann got married. Offer to succeed rabbi Michael Sachs in Berlin. Division and intrigues in the Jewish community and withdrawing from the position. Invitation to give a sermon in Vienna. In 1866 Moritz Guedemann was nominated to succeed rabbi Mannheimer at the Leopoldstadt synagogue in Vienna. Austro-Prussian war and defeat of Austria in Koeniggraetz. Initial difficulties and cultural differences. Criticism toward his orthodox conduct in the Vienna Jewish press ("Neuzeit"). Cultural life in Vienna. Welfare institutions and philanthropists. Difference within the Jewish community. Crash of the stock exchange and rise of antisemitism. Publication of sermons and studies in Jewish history. In 1891 Max Guedemann became chief rabbi of Vienna. Speeches against antisemitism and blood libel trials. He was awarded with the title "Ritter" of the Kaiser Franz Joseph order for these achievements. Death of his wife in

Franks family papers, 1711-1821, [1965-1968].

Contains business correspondence, accounts and documents relating to Jacob Franks of New York, his two sons, Moses and David, a nephew, Isaac, and a John Franks of Halifax, possibly a member of the family.

Industrial Removal Office records undated, 1899-1922

Contains Board of Directors minutes (1903, 1907), Executive Committee minutes (1907), Removal Committee minutes (1903-1917), Annual Reports (1910, 1913), Monthly Reports (1901-1919), Monthly Bulletins (1914-1915), studies of those removed, Bressler's "The Removal Work, Including Galveston," and several papers relating to the IRO and immigration. Financial papers include a budget (1914), comparative per capita cost figures (1909-1922), audits (1915-1918), receipts and expenditures (1918-1922), investment records, bank balances (1907-1922), removal work cash book (1904-1911), office expenses cash account (1903-1906), and the financial records of other agencies working with the IRO (1906). Includes also removal case records of first the Jewish Agricultural Society (1899-1900), and then of the IRO (1901-1922) when it took over its work, family reunion case records (1901-1904), and the follow-up records of persons removed to various cities (1903-1914). Contains also the correspondence of traveling agents' contacts throughout the U.S. from 1905-1914, among them Stanley Bero, Henry P. Goldstein, Philip Seman, and Morris D. Waldman.

Ennaltamäärätty kääntymys: Predestinaatio ja vapaan tahdon ongelma Jonathan Edwardsin teologiassa

Tämän tutkielman tehtävänä on ollut selvittää onko ihmisellä vapaata tahtoa Jonathan Edwardsin mukaan. Lähteenäni minulla on ollut Edwardsin Freedom of the Will -teos sekä Miscellaneous- sarjasta Concerning the Divine Degrees -kirjoitus. Metodina minulla on ollut systemaattinen analyysi. Edwardsin taustana oli puritanismi. Esimerkiksi sakramenteilla ei ollut puritanismin piirissä samaa ratkaisevaa merkitystä uskon synnyttäjänä ja ylläpitäjänä kuin perinteisissä kristillisissä kirkoissa oli ollut. Puritanistien keskeinen armonväline oli saarna. Saarnalla pyrittiin vaikuttamaan ihmisen tahtoon antamalla rationaalisia perusteita Raamatun pelastustapahtumasta. Tämä on nähtävissä myös Jonathan Edwardsin teologiassa. Deismi ja valistus vaikuttivat myös Edwardsin aikaiseen ajatteluun voimakkaasti. Edwardsin Berkeleytä muistuttava idealismi kuitenkin takasi sen, että Jumala ei irronnut maailmasta vaan oli kaikessa koko ajan läsnä. Erityisesti Locke Newtonin luonnontieteiden filosofina vaikutti Edwardsin filosofiseen ajatteluun tahdon vapaus -kysymyksen osalta. Edwards pyrki Locken ja Newtonin avulla puolustamaan perinteistä kalvinistista kristillisyyttä. Tämän kilpailijaksi puritanismin piirissä oli tullut ajan henkeen sopiva järkiperäinen arminiolaisuus, joka edusti myös anti-revivalismia. Tähän arminiolaisuuteen liittyi perinteisistä kristillisistä opeista luopuminen. Tämä arminiolaisuus oli kehittynyt antropologisempaan suuntaan Remonstranssin ajoista korostaen ihmisen vapaita tahdon akteja. Näin ihminen pystyi päättämään uskoiko hän vai ei. Edwardsille usko ja pelastuminen perustuivat Jumalan valintaan, jossa kolmiyhteinen Jumala otti ihmisen yhteyteensä. Tämä kääntymys ilmeni kommuuniona ja uniona Kristuksen kanssa. Edwardsin ajattelua tahdon vapauden osalta avaa kompatibilismi. Kompatibilismin mukaan ennaltamäärääminen ei ole ristiriidassa vapaan tahdon kanssa, vaan päinvastoin sen lähtökohta ja perusta. Kääntymissä olemme eri näkökulmista täysin passivisia ja täysin aktiivisia. Kompatibilismin myötä Edwardsin kirjoitusten pohjalta pystytään johtamaan ennalta määrätty uskonratkaisu. Myöhemmin Edwardsin seuraajat New Lights harppasivat ironisesti arminiolaiseen suuntaan korostaen juuri uskonratkaisua. Vaikka Jumalalla on sanan varsinaisessa merkityksessä vapaa tahto, niin silti Hän toimii välttämättä pyhästi. Samoin Jeesus Kristus on linkkinä ihmisten välttämättömälle, mutta vastuulliselle toiminnalle. Jeesuksen valinta on kaikkien pyhien valinnan perusta. Ne, jotka Jumala hylkää helvettiin saavat oikeudenmukaisen rangaistuksen, koska Jumala rankaisee heissä itsessään olevaa pahaa. Se, miksi Jumala valitsee toiset ja hylkää toiset, kuuluu Jumalan salattuun tahtoon. Jumalan ilmoitetun tahdon mukaan Hän tahtoo kaikkien pelastuvan. Arminiolaiset hylkäävät ennaltamääräämisen, mutta hyväksyvät ennalta tietämisen. Edwardsille nämä ovat sama asia. Edwardsin mukaan välttämättömyys ei ole ristiriidassa vapauden kanssa. Luonnollisella ja moraalisella välttämättömyydellä on yhteys. Arkikielessä moraalista välttämättömyyttä ei oleteta. Koko tahdon vapaus -kysymys on pitkälti kielellinen. Arkikielessä ja filosofisessa kielessä on ero. Tahto ei ole agentti, joka voi valita itsenäisesti. Vapaus on ihmisen, ei tahdon ominaisuus. Siksi kysymys tahdon vapaudesta tulisi esittää onko ihminen vapaa. Edwards ja arminiolaiset ymmärtävät vapauden eri tavoin. Edwardsin mukaan tahdolla on oltava alku, eikä tahto voi koskaan arminiolaisten tavoin neutraali. Arminiolaiset hylkäävät perisyntiopin klassisessa merkityksessä, mistä seuraa erilainen lähtökohta. Sellaisena kuin arminiolaiset esittävät vapaan tahdon, meillä ei sitä Edwardsin mukaan ole. Vaikka kaikki tapahtuu Edwardsin mukaan välttämättä, niin silti olemme vastuullisia moraalisia agentteja.

CTFS-ForestGEO: a worldwide network monitoring forests in an era of global change

Global change is impacting forests worldwide, threatening biodiversity and ecosystem services including climate regulation. Understanding how forests respond is critical to forest conservation and climate protection. This review describes an international network of 59 long-term forest dynamics research sites (CTFS-ForestGEO) useful for characterizing forest responses to global change. Within very large plots (median size 25ha), all stems 1cm diameter are identified to species, mapped, and regularly recensused according to standardized protocols. CTFS-ForestGEO spans 25 degrees S-61 degrees N latitude, is generally representative of the range of bioclimatic, edaphic, and topographic conditions experienced by forests worldwide, and is the only forest monitoring network that applies a standardized protocol to each of the world's major forest biomes. Supplementary standardized measurements at subsets of the sites provide additional information on plants, animals, and ecosystem and environmental variables. CTFS-ForestGEO sites are experiencing multifaceted anthropogenic global change pressures including warming (average 0.61 degrees C), changes in precipitation (up to +/- 30% change), atmospheric deposition of nitrogen and sulfur compounds (up to 3.8g Nm(-2)yr(-1) and 3.1g Sm(-2)yr(-1)), and forest fragmentation in the surrounding landscape (up to 88% reduced tree cover within 5km). The broad suite of measurements made at CTFS-ForestGEO sites makes it possible to investigate the complex ways in which global change is impacting forest dynamics. Ongoing research across the CTFS-ForestGEO network is yielding insights into how and why the forests are changing, and continued monitoring will provide vital contributions to understanding worldwide forest diversity and dynamics in an era of global change.

Evaluación de Rhizobium tropici UMR 1899 en tres variedades de frijol común (Phaseolus vulgaris L.) y la extracción de macronutrientes primarios por el cultivo

El presente trabajo fue realizado en la finca experimental La Compañía, Carazo, en época de postrera (octubre- diciembre de 1996), en suelos jóvenes de origen volcánico con altos contenidos de potasio y deficiente de fósforo. El propósito del experimento fue determinar la influencia de dos tipos de Rhizobium en tres variedades de frijol común (Phaseolus vulgaris L.), sobre la producción de materia seca y rendimiento, así como la extracción de los elementos mayores tales como N, P y K. Las variedades evaluadas fueron: Honduras - 46, DOR - 364 y Revolución - 79 y los tipos de Rhizobium evaluados fueron: Rhizobium tropici UMR 1899 y la bacteria nativa Rhizobium leguminosarum bv phaseoli. El diseño utilizado fue bloques completos al azar (B.C.A), con seis tratamientos y cuatro repeticiones. Las variables evaluadas fueron: altura de planta, número de nódulos, peso seco de nódulos, peso seco de cada nódulo, materia seca, densidad de plantas por hectárea, número de vainas por planta, número de granos por vaina, peso de 100 granos, rendimiento y extracciones de macronutrientes como N, P y K. Los datos se procesaren usando análisis de varianza (ANDEVA) y se utilizó la prueba de rangos múltiples de DUNCAN (Ps0.05). Los resultados obtenidos se pueden sintetizar de la siguiente forma: la variedad Honduras - 46, presentó mayor producción de materia seca en los tejidos del follaje (1563.23 kg/ha), así como también obtuvo el mayor rendimiento (1 000.51 kg/ha), la variedad Revolución - 79 obtuvo la mayor producción de materia seca en los tejidos de la raíz (117.91 Kg/ha). La variedad DOR - 364 obtuvo la mayor extracción de macro nutrientes primarios (67.12 kg/ha de nitrógeno, 6.90 kg/ha de fósforo y 60.91 kg/ha de potasio). La bacteria nativa Rhlzobium leguminosarum bv phaseoli obtuvo la mayor producción de materia seca en los tejidos del follaje y la raíz, asi como en el rendimiento y extracciones totales de macronutrientes primarios.

Região occidental de Matto Grosso : viagem e estudos sobre o Valle do Baixo Guaporé : da cidade de Matto Grosso ao Forte de Principe da Beira pelo Dr. Manoel Esperidião da Costa Marques, 1906. A seguir : Projectos de vias de communicação : exploração do Alto Guaporé e dos rios Jaurú, Aguapehy e Alegre : do mesmo autor, 1899

Apontamentos, notas e narrativas sobre o vale do Baixo Guaporé, com detalhes sobre riqueza, civilização, indústria, comércio, população, comunidades indígenas, usos e costumes.

Collecção das Leis da Republica dos Estados Unidos do Brazil de 1899

Parte 1 - Atos do Poder Legislativo