292 resultados para Transkutane Immunisierung, Imiquimod, Squalen, Jojobawachs, gefriergetrocknete feste Nanoemulsion, Saccharose-Fettsäureester, Emulsionsgel
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von Hans Blaufuss
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von Leopold Stein
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Boberach: Da Staat und die Kirche sich voneinander entfernen, der Staat vielleicht sogar in Gegensatz zur Kirche treten wird, sollen Christen von ihren politischen Rechten keinen Gebrauch machen
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BACKGROUND More data are needed to define factors that predict long-term success after imiquimod therapy for lentigo maligna (LM). OBJECTIVE We sought to determine the demographic, clinical, and histologic prognostic markers of relapse-free survival in patients with LM who were treated with imiquimod. METHODS This was a single-arm, open-label, nonrandomized, prospective study. RESULTS Eighty-nine patients with histologically confirmed LM and a median follow-up time of 4.8 years after imiquimod treatment were included in our study. Sixteen patients (18%) relapsed. Statistically significant indicators of an increased risk of local recurrence included: the total number of melanocytes, the number of basal and suprabasal melanocytes and the number of pagetoid spreading melanocytes. LIMITATIONS Our study was a single-center, nonrandomized study. CONCLUSION An assessment of different melanocyte fractions in the diagnostic baseline biopsy specimen may help to predict the response of LM to imiquimod therapy.
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Jakob Weil
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Markus Mordechai Bär Friedenthal
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Stein
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W.
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Martin Buber
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David Oppenheim
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Leopold Treitel
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Leopold Treitel
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Leopold Treitel
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Leopold Treitel