Tim Burton : las alegres pesadillas del melancólico Niño Ostra.

La melancólica muerte del Chico Ostra, es todo un ejemplo del particular universo de Tim Burton, autor entre otros títulos de: Eduardo Manostijeras, La leyenda de Sleepy Hollow o Pesadilla antes de Navidad. Pertenece a una larga tradición anglosajona de fabulistas crueles, ingeniosos y de retorcida moral, aunque indudablemente moralistas, cuyas obras se mueven en las imprecisas y turbulentas aguas de una literatura infantil para adultos que difícilmente puede aceptarse como indicada para niños, pero en la que son precisamente los niños quienes encuentran el máximo disfrute, y la inequívoca expresión de la niñez como algo mucho más complejo, cruel, patético, agridulce y siniestro, a la par que divertido, lúdico y amoral. En este artículo se hace un recorrido por toda su obra y las influencias que ha recibido de otros autores como el literato Dr. Seuss o el ilustrador Gorey.

Immediate recall by aphasic, deaf and normally hearing children for visual forms presented simultaneously or sequentially in tim

This paper discusses a study to investigate immediate recall of visual stimuli presented simultaneously or sequentially in time.

Writing, death and absence in 'Tim' by H.O. Sturgis

There has been a considerable critical interest in the representation of death in Children's Literature, with an increasingly prevalent move to read it as granting the child the status of object. Thus, for example, Judith Plotz takes it to 'increase [the] presence' of the child. Through a detailed reading of one late C19th school story, I suggest that such readings proceed through a resistance to textuality. This essay offers a reading of death as bound up with the play of the text, deferred, shifting and retrospectively constructed rather than a state of simple, recoverable objecthood.

Detection of the Tim-3 ligand, galectin-9, inside the allograft during a rejection episode

Introduction: Tim-3 is a Th1 lymphocytes membrane protein with inhibitory function. Its ligand, galectin-9, was recently identified and it is expressed in some lymphocyte subpopulation. In addition, endothelial cells and fibroblasts can also express galectin-9 according to the local cytokine milieu. Both molecules can act as important regulatory tools in the immune system. Aim: Evaluate the expression of these immunoregulatory molecules inside kidney allografts during acute rejection episodes. Methods: By using a quantitative polymerase chain reaction assay, we measured the levels of messenger RNA (mRNA) for galectin-9 and Tim-3 in 21 samples obtained at allograft nephrectomy. Five samples received the histological diagnosis of acute non-vascular rejection (ANVR), twelve of acute vascular rejection (AVR), and five of loss of non-immune cause (LNIC; as control). As cytolytic response markers we measured mRNA levels of granzyme B, interferon-gamma and perforin. The statistic analysis was performed using one way analysis of variance (ANOVA) and Pearson correlation. Results: The mean levels of Tim-3 mRNA expression were 13.99 +/- 6.99 for LNIC, 48.13 +/- 54.47 for RACNV and 238.63 +/- 333.14 for RAV (p = 0.004). For galectin-9, the mean values were 0.57 +/- 0.49 for LNIC, 0.66 +/- 0.36 for RACNV and 2.34 +/- 1.62 for RAV (p = 0.006). Furthermore, there was a positive correlation between both molecules (r = 0.526, p = 0.016). Also. granzyme B, perforin and interferon-gamma mRNA expression were different among the three groups. Conclusion: Messenger RNA level expressions of all the studied molecules were higher inside allografts with more severe rejection. Moreover, there was a positive correlation between galectin-9 and Tim-3 mRNA levels. The simultaneous expression of galectin-9 and Tim-3 may indicate an immunoregulatory function, during the ongoing cytotoxic response. (C) 2008 Elsevier B.V. All rights reserved.

Axial ligand influence on geometries, charge distributions and electronic structures of iron tetraazamacrocycle [Fe((II))TIM(X)(Y)](2+) complexes assessed by Density Functional Theory

We employed the Density Functional Theory along with small basis sets, B3LYP/LANL2DZ, for the study of FeTIM complexes with different pairs of axial ligands (CO, H(2)O, NH(3), imidazole and CH(3)CN). These calculations did not result in relevant changes of molecular quantities as bond lengths, vibrational frequencies and electronic populations supporting any significant back-donation to the carbonyl or acetonitrile axial ligands. Moreover, a back-donation mechanism to the macrocycle cannot be used to explain the observed changes in molecular properties along these complexes with CO or CH(3)CN. This work also indicates that complexes with CO show smaller binding energies and are less stable than complexes with CH(3)CN. Further, the electronic band with the largest intensity in the visible region (or close to this region) is associated to the transition from an occupied 3d orbital on iron to an empty pi* orbital located at the macrocycle. The energy of this Metal-to-Ligand Charge Transfer (MLCT) transition shows a linear relation to the total charge of the macrocycle in these complexes as given by Mulliken or Natural Population Analysis (NPA) formalisms. Finally, the macrocycle total charge seems to be influenced by the field induced by the axial ligands. (C) 2011 Elsevier Ltd. All rights reserved.

Tim O'Reilly and web 2.0 : the economics of memetic liberty and control

This article presents an account of the role of Tim O'Reilly, both as an individual and as a corporate entity (O'Reilly Group), in the creation, spread and use of the concept of Web 2.0. It demonstrates that, whatever Web 2.0's current uses to describe variously the technologies, politics, commerce or social meaning of the Internet, it originates as a deliberately open signifier of novel and potential internet development in the mid-2000s. The article argues that O'Reilly has promoted the diversity of the term's meanings and uses - celebrating textual liberties - but has also emphasised the special role that O'Reilly plays in providing the authoritative definition of that term. In essence, O'Reilly profits from this 'control' of the idea of Web 2.0 but that, to enjoy that control O'Reilly must also allow differences in meaning. The article concludes by suggesting that Web 2.0 therefore signifies a new kind of economics that brings together freedom and control in a new way.

Dreams of belonging : Tim Winton's Cloudstreet

This essay is on Tim Wnton's novel Cloudstreet. It was commissioned by Copyright Agency Australia. It is written for a specific audience, teachers of English Literature and senior secondary, junior University students. It is a literary critical essay.