Moderate Exercise Reduces Food Consumption in Obese Mice for Activate Jak-2/Stat-3 Pathway in the Hypothalami

It is very known that due to inflammatory processes the obesity leads to resistance to leptin, it reduces phosphorylation via JAK-2/STAT-3, which generates lower STAT-3 activity in the cell nucleus, and it leads to decrease the number of transcription of anorexigenic neurons (POMC/CART) and allowing transcription of orexigenic (NPY/AgRP). PURPOSE: The present study aimed to evaluate the effects of moderate aerobic training on food intake of obese mice through analysis of activity of hypothalamic proteins JAK-2/STAT-3. METHODS: It were used 30 Swiss mice (30 days old) divided into 3 groups: Control Group (C): sedentary animals fed with balanced diet ; Obese (OB) sedentary animals fed with high-fat diet throughout the experiment and Trained Obese (TOB) : animals fed with high fat diet throughout the experiment , kept sedentary during the first half of the experiment (8 weeks) and submitted to physical training protocol during the second half of the experiment (8 weeks). The exercise program consisted of treadmill running 1h, 5 days/week during 8 weeks at a speed equivalent to 60 % of maximum potency determined at the beginning of training period. To assess the leptin resistance, after rats were deprived of food for 6h with free access to water, they received i.p injection with leptin (2.0µl, 10-6M), after this, the chow was returned and food intake was determined by measuring the quantity and Kcal consumed at the end of 2h. The hypothalami was removed for determination of JAK-2 and STAt-3 activity. RESULTS: Our results showed that moderate physical exercise was effective in improving the JAK/STAT signaling pathway in the hypothalamus of obese animals. This has made these obese animals had reduced food intake and consequently lower body mass gain. CONCLUSION: It can be concluded that physical exercise, for restoring leptin signaling in the hypothalamus, controls the synthesis of neurons responsible for appetite and thus is an important tool in the treatment of obesity.

Perfil de suscetibilidade, genes de resistência aos aminoglicosídeos e similaridade genética em amostras de Acinetobacter baumannii isoladas em um Hospital Terciário

Pós-graduação em Microbiologia - IBILCE

Caracterización petrográfica de los travertinos aragoníticos del Barranco de Azuaje (Gran Canaria)

[ES]El Barranco de Azuaje está situado en el NE de la isla volcánica de Gran Canaria. El barranco se formó por incisión sobre depósitos volcánicos de edad inferior a 5,5 Ma. La presencia de depósitos de travertino situados dentro del barranco constituye un rasgo destacado. Estos travertinos están compuestos por aragonito fibroso y calcita, en menor cantidad. Las principales facies reconocidas son: laminar, masiva porosa, de granos con cubiertas y tobácea. Sus especiales texturas, el infrecuente contexto volcánico y el hecho de que el travertino se haya formado en un área sin depósitos carbonáticos previos, hacen de éste un travertino único entre los depósitos relacionados con manantiales.Las principales facies y la mineralogía sugieren que estos depósitos se formaron bajo la influencia de aguas termógenas por desgasificación rápida de CO2 en un sistema de cascadas y pozas.

Namenszug des Baalschem [Illustration] : (Autograph)

Baal-Schem-Tob Israel ben Elieser

Jonteb Lipmann Heller an seine Verwandte Edel [Illustration] : (Autograph)

Jom-Tob Lipmann ben Nathan ha-Levi Heller

Majorca Island, Minorca Island, and Isla de Ibiza, Spain, ca. 1756 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte des l'isles de Maiorque, Minorque et d'Yvice, gravée par Matthieu Seutter, Geographe de S.M. Imper. et Cathol. ; Tob. Conr. Lotter, sc. It was published by M. Seutter ca. 1756. Scale [ca. 1:560,000]. Covers Majorca Island, Minorca Island, and Isla de Ibiza, Spain. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, Universal Transverse Mercator (UTM) Zone 31N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, road, shoreline features, and more. Relief shown by hachures and pictorially. Includes 2 insets, one showing the islands and the western part of the Mediterranean, and, "Plan du port et ville de Mahon, du Fort. St. Philippe et ses fortifications."This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Yemen, 1774 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Terrae Yemen maxima Pars. seu Imperii Imami, Principatus Kaukebân, nec non ditionum Haschid U Bekîl, Nehhm, Chaulân, Abu Arîsch Et Aden Tabula : ex observationibus astronomicis et hodometricis jussu et suntibus Potentissimor: Daniae Regnum Friderici V et Christiani VII institutis, delineata Auctore C. Niebuhr ; Gustav Conrad Lotter Sculps. It was published by Tob. Conr. Lotter in 1774. Scale [ca. 1,250,000]. Covers a portion of Yemen and Saudi Arabia. Map in Latin. The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Miller Cylindrical projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection as part of the Open Collections Program at Harvard University project: Islamic Heritage Project. Maps selected for the project represent a range of regions, originators, ground condition dates, scales, and purposes. The Islamic Heritage Project consists of over 100,000 digitized pages from Harvard's collections of Islamic manuscripts and published materials. Supported by Prince Alwaleed Bin Talal and developed in association with the Prince Alwaleed Bin Talal Islamic Studies Program at Harvard University.

Terrae Yemen maxima Pars. seu Imperii Imami, Principatus Kaukebân, nec non ditionum Haschid U Bekîl, Nehhm, Chaulân, Abu Arîsch Et Aden Tabula: ex observationibus astronomicis et hodometricis jussu et suntibus Potentissimor: Daniae Regnum Friderici V et Christiani VII institutis

delineata Auctore C. Niebuhr ; Gustav Conrad Lotter Sculps.

Thamos, König in Ägypten. [music] : historisches Drama mit Musik. Klavierauszug.

Libretto by Tob. Phil. Freiherr von Gebler. Köchel Nr. 345.

[Wallachian Testament]

Mode of access: Internet.

Flue-cured tobacco market review.

Vols. for 1957- issued as the division's TOB-FL-1-

Kyōto sōsho /

[1] Kyōwarabe, Atooi, Tsuginefu -- [2] Dekisai Kyō miyage, Horik awa no mizu, Kyō uchimairi, Miyako kagetsu meisho -- [3] Rakuyō meishoshū, Keishi junranshū, Kinki rekiranki -- [4] Fusō keikashi, Meisho miyakodori, Kyō machikagami -- [5] Kyō suzume, Ymashiro meiseki junkōshi, Keijō shōran, Miyako meishoguruma -- [6-7] Yamashiro meishōshi -- [8] Kyōhabutae, Kyōhabutae oridome, Yamashiro meisho jisha monogatari, Rakuyō jūnisha reigenki -- [9-13] Kyōtobō mokushi -- [14] Miyako meisho zue, Miyako meisho zue shūi -- [15] Yōshū fushi, Hinami kiji -- [16] Sakuin.

The white hecatomb, and other stories /

The white hecatomb -- The vengeance of the Dogolwana -- Gquma, or, The white waif -- The tramp's tragedy -- The seed of the church -- Little Tobè -- The Imishologu -- The madness of Gweva -- The love charm -- Derelicts -- The return of Sobèdè -- The quick and the dead -- Aiala.

Hayim ve-hesed. : Helek A[lef] ...

Vol. 2 published by Haktav Institute, Jerusalem.

Maʻaśe tsadiḳim : ... ḥidushe ha-Ramban ʻal masekhet ʻAvodah zarah ... : ḥidushe ha-Riṭba ʻal masekhet Shevuʻot ...

Mode of access: Internet.