Protein folding from a highly disordered denatured state: The folding pathway of chymotrypsin inhibitor 2 at atomic resolution

Previous experimental and theoretical studies have produced high-resolution descriptions of the native and folding transition states of chymotrypsin inhibitor 2 (CI2). In similar fashion, here we use a combination of NMR experiments and molecular dynamics simulations to examine the conformations populated by CI2 in the denatured state. The denatured state is highly unfolded, but there is some residual native helical structure along with hydrophobic clustering in the center of the chain. The lack of persistent nonnative structure in the denatured state reduces barriers that must be overcome, leading to fast folding through a nucleation–condensation mechanism. With the characterization of the denatured state, we have now completed our description of the folding/unfolding pathway of CI2 at atomic resolution.

Constitutional reason of state : the survival of the constitutional order /

Includes bibliographical references and index.

Racial state, the German nationalities policy in the protectorate of Bohemia-Moravia,

Bibliographical references included in "Footnotes" (p. [277]-303) Bibliography: p. [325]-347

At a General Assembly begun at Dover, in the Delaware State, ... the following Acts were passed ...

The 111th, 112th, and 113th session laws are lacking because it was ascertained by the Public Archives Commission that the regular session of the Delaware General Assembly which convened in January 1947 was the 114th regular Legislative session held following the adoption of the state's first Constitution in 1776.

Visa procedures of Department of State: the Struelens case. Report of the Subcommittee to Investigate the Administration of the Internal Security Act and Other Internal Security Laws to the Committee on the Judiciary, United States Senate, Eighty-seventh Congress, second session.

At head of title: 87th Cong., 2d sess. Committee print.

Departments of Commerce, Justice, and State, the Judiciary, and related agencies appropriations for 1985 [microform] : hearings before a subcommittee of the Committee on Appropriations, House of Representatives, Ninety-eighth Congress, second session /

Includes indexes.

An elementary system of physiology, comprising a complte view of the present state the science ... /

Mode of access: Internet.

Departments of Commerce, Justice, and State, the Judiciary, and related agencies appropriations for 1988 : hearings before a subcommittee of the Committee on Appropriations, House of Representatives, One hundredth Congress, first session /

Shipping list no.: 87-255-P (pts. 8-9).

The individual and the state : the problem as presented by the sentencing of Roger N. Baldwin.

Cover title.

Authorizing additional appropriations for the Department of State, the Board for International Broadcasting, and grants to Radio Free Europe/Radio Liberty for fiscal years 1980 and 1981 : hearings before the Subcommittee on International Operations of the Committee on Foreign Affairs, House of Representatives, Ninety-sixth Congress, second session, March 26 and April 16, 1980.

Mode of access: Internet.

Sketches of the early Catholic missions of Kentucky : from their commencement in 1787, to the Jubilee of 1826-7, embracing a summary of the early history of the state, the adventures of the first Catholic emigrants, biographical notices of the early missionaries, the early history of the principal Protestant sects in Kentucky, with some account of the establishment of the episcopal see at Bardstown, of the various religious societies, and of the general state of the Catholic religion in Kentucky /

Preface dated (p. ix): Bardstown, Kentucky, Feast of Corpus Christi, 1844.

The surprising case of Rachel Baker, who prays and preaches in her sleep, with specimens of her extraordinary performances taken down accurately in short hand at the time; and showing the unparelleled powers she possesses to pray, exhort, and answer questions, during her unconscious state. The whole authenticated by the most respectable testimony of living witnesses.

Further utterances ascribed to Rachel Baker were published in Devotional somnium, edited by J. H. Douglass, New York, 1815.

The surprising case of Rachel Baker, who prays and preaches in her sleep : with specimens of her extraordinary performances taken down accurately in short hand at the time; and showing the unparalleled powers she possesses to pray, exhort, and answer questions, during her unconscious state. The whole authenticated by the most respectable testimony of living witnesses /

Signatures: A-D⁴.

A new history of the life and reign of the Czar Peter the Great, Emperor of all Russia, and father of his country : Giving an exact relation of I. His travels, studies, and personal fatigues, for the attaining of knowledge in civil and military affairs, and the improvement of his subjects. II. His introduction of arts and sciences, a naval force, and commerce with foreign nations; also his many reformations in church and state, the army, and the customs and manners of his people. III. His wars with the Swedes, Turks, Tartars and Persians; victories by sea and land; acquisitions of territory, and increase of power. IV. His regard to genius and merit, particularly in the instances of General Le Fort, Prince Menzikoff, and the Empress Catharine: and his severe justice on offenders, exemplified in the proceedings against the czarewitz, and others. /

By John Bancks.