Holocene vegetation development in the catchment of Sagistalsee (1935 m asl), a small lake in the Swiss Alps

Pollen and plant macrofossils were analysed at Sägistalsee (1935 m asl), a small lake near timber-line in the Swiss Northern Alps. Open forests with Pinus cembra and Abies alba covered the catchment during the early Holocene (9000–6300 cal. BP), suggesting subcontinental climate conditions. After the expansion of Picea abies between 6300 and 6000 cal. BP the subalpine forest became denser and the tree-line reached its maximum elevation at around 2260 m asl. Charcoal fragments in the macrofossil record indicate the beginning of Late-Neolithic human impact at ca. 4400 cal. BP, followed by a extensive deforestation and lowering of the forest-limit in the catchment of Sägistalsee at 3700 cal. BP (Bronze Age). Continuous human activity, combined with a more oceanic climate during the later Holocene, led to the local extinction of Pinus cembra and Abies alba and favoured the mass expansion of Picea and Alnus viridis in the subalpine area of the Northern Alps. The periods before 6300 and after 3700 cal. BP are characterised by high erosion activity in the lake's catchment, whereas during the phase of dense Picea-Pinus cembra-Abies forests (6300–3700 cal. BP) soils were stable and sediment-accumulation rates in the lake were low. Due to decreasing land-use at higher altitudes during the Roman occupation and the Migration period, forests spread beween ca. 2000 and 1500 cal. BP, before human impact increased again in the early Middle Ages. Recent reforestation due to land-use changes in the 20th century is recorded in the top sediments. Pollen-inferred July temperature and annual precipitation suggest a trend to cooler and more oceanic climate starting at about 5500 cal. BP.

CHARACTERIZATION OF SELECTIVE INHIBITION OF ADENYLYL CYCLASE ACTIVITY BY SMALL MOLECULE INHIBITOR NKY80

The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule cyclic AMP (cAMP), are involved in many isoform specific physiological functions. Decreasing AC5 activity has been shown to have potential therapeutic benefit, including reduced stress on the heart, pain relief, and attenuation of morphine dependence and withdrawal behaviors. However, AC structure is well conserved, and there are currently no isoform selective AC inhibitors in clinical use. P-site inhibitors inhibit AC directly at the catalytic site, but with an uncompetitive or noncompetitive mechanism. Due to this mechanism and nanomolar potency in cell-free systems, attempts at ligand-based drug design of novel AC inhibitors frequently use P-site inhibitors as a starting template. One small molecule inhibitor designed through this process, NKY80, is described as an AC5 selective inhibitor with low micromolar potency in vitro. P-site inhibitors reveal important ligand binding “pockets” in the AC catalytic site, but specific interactions that give NKY80 selectivity are unclear. Identifying and characterizing unique interactions between NKY80 and AC isoforms would significantly aid the development of isoform selective AC inhibitors. I hypothesized that NKY80’s selective inhibition is conferred by AC isoform specific interactions with the compound within the catalytic site. A structure-based virtual screen of the AC catalytic site was used to identify novel small molecule AC inhibitors. Identified novel inhibitors are isoform selective, supporting the catalytic site as a region capable of more potent isoform selective inhibition. Although NKY80 is touted commercially as an AC5 selective inhibitor, its characterization suggests strong inhibition of both AC5 and the closely related AC6. NKY80 was also virtually docked to AC to determine how NKY80 binds to the catalytic site. My results show a difference between NKY80 binding and the conformation of classic P-site inhibitors. The selectivity and notable differences in NKY80 binding to the AC catalytic site suggest a catalytic subregion more flexible in AC5 and AC6 that can be targeted by selective small molecule inhibitors.

How small and medium enterprises can begin their implementation of ITIL?

Sequencing of Information Technology Infrastructure Library (ITIL) processes related to their order of implementation is one of the pending issues in the ITIL handbooks. Other frameworks and process models related to service management (e.g., COBIT, COSO and CMMI-SVC) are quite well described in the literature and their handbooks. However, the identifi cation of the fi rst process to be implemented has not been deeply analysed in the previous frameworks and models, and it is also a complex question to answer for organizations, especially Small and Medium Enterprises (SMEs). Moreover, SMEs are the organizations that have the largest presence in the world economy; offi cial data of General Business Directory, show that their range of presence in different countries around the world is between 93% and 99%, and the average of employment contribution is around 60%. Consequently, the improvement of information technology service management is of vital importance to accomplish in this type of enterprises. This research has focused on two surveys that aim at helping SMEs to select the ITIL process by which starting the implementation of ITIL. In the fi rst survey, data were gathered through a questionnaire to SMEs registered in the region of Madrid. The second survey obtained data from experts and enterprises in countries as Spain, Ecuador, Chile, Luxembourg, Colombia, Norway, El Salvador, and Venezuela. Finally, the results of both surveys show that the tendency for starting an ITIL implementation in SMEs points to one of the processes included in the Service Operation.

Polarized–unpolarized ground state of small polycyclic aromatic hydrocarbons

Do polyacenes, circumacenes, periacenes, nanographenes, and graphene nanoribbons show a spin polarized ground state? In this work, we present monodeterminantal (Hartree–Fock (HF) and density functional theory (DFT) types), and multideterminantal calculations (Møller–Plesset and Coupled Cluster), for several families of unsaturated organic molecules (n-Acenes, n-Periacenes and n-Circumacenes). All HF calculations and many DFT show a spin-polarized (antiferromagnetic) ground state, in agreement with previous calculations. Nevertheless, the multideterminantal calculations, carried out with perturbative and variational wavefunctions, show that the more stable state is obtained starting from the unpolarized HF wavefunction. The trend of the stabilization of wavefunctions (polarized or unpolarized) with respect to exchange and correlation potentials, and to the number of benzene rings, has been analyzed. A study of the spin (〈Ŝ2〉) and the spin density on the carbon atoms has also been carried out.

The Starting and managing series.

Mode of access: Internet.

Resource directory for minorities, women, veterans and disabled persons starting or owning a business.

"This publication has been made available through a partnership of the Illinois Department of Commerce and Economic Opportunity's Illinois Entrepreneurship Network Business Information Center, the Small Business Development Center Network and the U.S. Small Business Administration."--p. [4] of cover.

Starting a business in Illinois /

"Developed in cooperation with the U.S. Small Business Administration, the Illinois Department of Commerce and Community Affairs, and the First Stop Business Information Center of Illinois as a service to Illinois small businesses ... "

Starting a business in Illinois : handbook.

The Illinois Entrepreneurship Network was established throughout the state to provide business management, counseling and training, assistance in entering international markets, information on competing for the state and federal contracts, developing technology related products and providing a supportive environment for new, startup businesses. This network consists of Small Business Development Centers, Procurement Technical Assistance Centers, International Trade/NAFTA Centers, Small Business Incubators and of course Entrepreneurship Centers. Assistance is provided in the areas of preparing business and marketing plans, securing capital, improving business skills, accessing international trade opportunities and addressing other business management needs. DCEO also has programs targeted to assist minority and women-owned business concerns. The Illinois Entrepreneurship Network is a collaborative arrangement among DCEO, the US Small Business Administration, the US Department of Defense, colleges and universities and private business organizations. Pursuant to the Business Assistance and Regulatory Reform Act, the Illinois Department of Commerce and Economic Opportunity (DCEO) created the IEN Business Information Center of Illinois (the Center). The goal of the Center is to enhance the state's business climate by making it easier for businesses to comply with government requirements and gain access to the information they need to be competitive. Whether a startup or existing business, this handbook will inform you of various legal requirements and guide you to additional resources.

Starting a business in Illinois /

"First stop business information center."

Starting a winery in Illinois : profile and business plan workbook /

"Updated ... by Bradley Beam." -- p. [1].

Starting your business in Illinois handbook /

"IISG08-278; 11/07."

An examination of the appropriateness of the contemporary strategic management models for the Greek small manufacturing enterprises

The starting point of the project was the observation that strategic management is absent in small businesses. The first objective of the project was to examine the reasons causing this situation in Greece, the second one, to examine the appropriateness of the contemporary models of strategic planning for the Greek S.M.E.s, and the third to examine the appropriateness of the alternative approaches to strategic management for the Greek S.M.E.s. The term appropriateness includes (a) the ability of managers to use the models and (b) the ability of the models to assist the managers. The results of the research indicate that none of the two above conditions exists, hence, it is suggested that the contemporary models of strategic management are inappropriate for the Greek S.M.E.s. Many previous research projects on the topic suggest that since the strategic decision making process in S.M.E.s is informal, the whole process is absent or ineffective. Current trends in S.M.E.s' strategic management do not consider the informality of the strategic decision making process as a kind of managerial illness, but as a managerial characteristic. The use of sophisticated data collection and analytical methods does not indicate successful strategic decisions, but it indicates the method large firms use to manage their strategy. According to the literature review, the S.M.E.s' managers avoid the use of the contemporary models of strategic management, because they do not have the knowledge, the resources or the time. Another thesis, expressed by some firms' specialists, suggests that small firms are different from large ones, hence their practice of strategic management should not follow the large firm's prototypes.

Az e-business kooperatív turisztikai adaptációja : "A kicsi, a szép esélyei hazánkban" (The cooperative touristy adoption of e-business: "The chances of small beautiful in Hungary")

A cikk legfontosabb megválaszolandó kérdése: Milyen esélyekkel és milyen szükséges lépésekkel indulhatnak a nemzetközileg kevéssé ismert hazai célállomások és vállalkozásaik a turisztikai piac globális versenyében, melynek egyre jelentősebb színterét az internet adja? A turisztikai piacon az internet piacalakító hatása és az individualista, élmény, és értékközpontú kereslet megjelenése olyan változásokat indított el az elmúlt közel húsz évben, melyek befolyásolva a szereplők erőviszonyait a fejlődés lehetőségét hordozzák a regionális célállomások, a kevéssé ismert desztinációk számára. Mindezen trendek egyúttal kihívást jelentenek, mivel élesítik a versenyt, és megújulásra ösztönzik a globálisan ismert desztinációkat is, valamint számos nehézség megoldására késztetik a több szempontból hátrányban szenvedő vidéki régiókat. A cikkben ismertetendő kutatás célja az, hogy egy best practice-ként ismert osztrák és három hazai eset alapján felderítse azon tényezőket, melyek a desztinációfejlesztés kezdeti lépésétől az e-business sikeres adaptációjához, a desztinációmenedzsment-rendszerek bevezetéséhez és működtetéséhez vezetnek. __________ The main question of the paper: What kind of steps should the Hungarian less-known destinations take to meet the challenges of the global competition increasingly taking place on the internet? The trends of “new tourism” – driven by post-materialistic values –, and the growing role of internet in touristy activity have formed new conditions and changed the balance of forces in the touristy market. These two trends hand in hand have intensified the competition: on the one hand force global destinations to renew, on the other hand give great but challenging possibilities for regional destinations in comparative disadvantage. The aim of the paper is to identify the success-factors of adopting e-business solution called destination management system in the regional, undeveloped areas starting destination management from zero position. For this purpose case studies were examined by analyzing Hungarian regional destinations’ development and making a benchmark analysis through an Austrian best practice.

Truncation identities for the small polaron fusion hierarchy

We study a one-dimensional lattice model of interacting spinless fermions. This model is integrable for both periodic and open boundary conditions; the latter case includes the presence of Grassmann valued non-diagonal boundary fields breaking the bulk U(1) symmetry of the model. Starting from the embedding of this model into a graded Yang-Baxter algebra, an infinite hierarchy of commuting transfer matrices is constructed by means of a fusion procedure. For certain values of the coupling constant related to anisotropies of the underlying vertex model taken at roots of unity, this hierarchy is shown to truncate giving a finite set of functional equations for the spectrum of the transfer matrices. For generic coupling constants, the spectral problem is formulated in terms of a functional (or TQ-)equation which can be solved by Bethe ansatz methods for periodic and diagonal open boundary conditions. Possible approaches for the solution of the model with generic non-diagonal boundary fields are discussed.