Receipt bearing the letterhead Masonic Temple, London, England

Receipt bearing the letterhead Masonic Temple, London, England yet the receipt seems to be from James D. Tait of St. Catharines for clothing, Aug. 14, 1886.

Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity

Metabolic bioactivation, glutathione depletion, and covalent binding are the early hallmark events after acetaminophen (APAP) overdose. However, the subsequent metabolic consequences contributing to APAP-induced hepatic necrosis and apoptosis have not been fully elucidated. In this study, serum metabolomes of control and APAP-treated wild-type and Cyp2e1-null mice were examined by liquid chromatography-mass spectrometry (LC-MS) and multivariate data analysis. A dose-response study showed that the accumulation of long-chain acylcarnitines in serum contributes to the separation of wild-type mice undergoing APAP-induced hepatotoxicity from other mouse groups in a multivariate model. This observation, in conjunction with the increase of triglycerides and free fatty acids in the serum of APAP-treated wild-type mice, suggested that APAP treatment can disrupt fatty acid beta-oxidation. A time-course study further indicated that both wild-type and Cyp2e1-null mice had their serum acylcarnitine levels markedly elevated within the early hours of APAP treatment. While remaining high in wild-type mice, serum acylcarnitine levels gradually returned to normal in Cyp2e1-null mice at the end of the 24 h treatment. Distinct from serum aminotransferase activity and hepatic glutathione levels, the pattern of serum acylcarnitine accumulation suggested that acylcarnitines can function as complementary biomarkers for monitoring the APAP-induced hepatotoxicity. An essential role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the regulation of serum acylcarnitine levels was established by comparing the metabolomic responses of wild-type and Ppara-null mice to a fasting challenge. The upregulation of PPARalpha activity following APAP treatment was transient in wild-type mice but was much more prolonged in Cyp2e1-null mice. Overall, serum metabolomics of APAP-induced hepatotoxicity revealed that the CYP2E1-mediated metabolic activation and oxidative stress following APAP treatment can cause irreversible inhibition of fatty acid oxidation, potentially through suppression of PPARalpha-regulated pathways.

Address of the Trustees of a London Charity School to the Parent of a proposed scholar, 1776 June 24

This two-and-a-half-page handwritten document contains a copy of a set of rules for a parent of a school identified as "Saint Mary Rotherhith United Society."

The ports of southern New England. (Revised 1937)

Reports on the ports of Providence and Newport, Rhode Island; New Bedford and Fall River, Mass.; New Haven, New London, Bridgeport, Norwalk and Stamford, Conn. cf. p. v.

Some results of research in the history of education in England with suggestions for its continuance and extension,

"Read November 25, 1914."--p. [1]

England and France in the fifteenth century. The contemporary Franch tract entitled "The debate between the heralds of France and England," presumed to have been written by Charles, duke of Orleans: translated for the first time into English; with an introduction, notes, an inquiry into the authorship, etc.

Mode of access: Internet.

A short inquiry into the policy, humanity and past effects of the poor laws : and into the principles upon which any measures for their improvement should be conducted : in which are included a few considerations on the questions of political oeconomy, most intimately connected with the subject : particularly on the supply of food in England /

Mode of access: Internet.

Description of the tread mill invented by Mr. William Cubitt, of Ipswich, for the employment of prisoners, and recommended by the Society for the improvement of prison discipline, &c.

Mode of access: Internet.

The Penny Cyclopaedia of the Society for the Difussion of Useful Knowledge.

Printed by William Clowes and son.

The Jaulân. Surveyed for the German society for the exploration of the Holy Land,

Issued with the Quarterly statement of the Palestine exploration fund, for Jan.-Apr., 1888.

The propriety of allowing a qualified exportation of wool discussed historically. To which is added an appendix: containing a table, which shews the value of the woolen goods of every kind, that were entered for exportation at the custom-house, from 1697 to 1780 inclusive, as well as the prices of wool in England, during all that period.

Mode of access: Internet.