3,4-Methylenedioxymethamphetamine (Ecstasy) Decreases Inflammation and Airway Reactivity in a Murine Model of Asthma

Objective:3,4-Methylenedioxymethamphetamine(MDMA), or ecstasy, is a synthetic drug used recreationally, mainly by young people. It has been suggested that MDMA has a Th cell skewing effect, in which Th1 cell activity is suppressed and Th2 cell activity is increased. Experimental allergic airway inflammation in ovalbumin (OVA)-sensitized rodents is a useful model to study Th2 response; therefore, based on the Th2 skewing effect of MDMA, we studied MDMA in a model of allergic lung inflammation in OVA-sensitized mice. Methods: We evaluated cell trafficking in the bronchoalveolar lavage fluid, blood and bone marrow; cytokine production; L-selectin expression and lung histology. We also investigated the effects of MDMA on tracheal reactivity in vitro and mast cell degranulation. Results: We found that MDMA given prior to OVA challenge in OVA-sensitized mice decreased leukocyte migration into the lung, as revealed by a lower cell count in the bronchoalveolar lavage fluid and lung histologic analysis. We also showed that MDMA decreased expression of both Th2-like cytokines (IL-4, IL-5 and IL-10) and adhesion molecules (L-selectin). Moreover, we showed that the hypothalamus-pituitary-adrenal axis is partially involved in the MDMA-induced reduction in leukocyte migration into the lung. Finally, we showed that MDMA decreased tracheal reactivity to methacholine as well as mast cell degranulation in situ. Conclusions:Thus, we report here that MDMA given prior to OVA challenge in OVA-sensitized allergic mice is able to decrease lung inflammation and airway reactivity and that hypothalamus-pituitary-adrenal axis activation is partially involved. Together, the data strongly suggest an involvement of a neuroinnmune mechanism in the effects of MDMA on lung inflammatory response and cell recruitment to the lungs of allergic animals. Copyright (C) 2012 S. Karger AG, Basel

Management of diabetes mellitus and associated cardiovascular risk factors in Brazil – the Brazilian study on the practice of diabetes care

Abstract Background The Brazilian Study on the Practice of Diabetes Care main objective was to provide an epidemiological profile of individuals with type 1 and 2 diabetes mellitus (DM) in Brazil, concerning therapy and adherence to international guidelines in the medical practice. Methods This observational, cross-sectional, multicenter study collected and analyzed data from individuals with type 1 and 2 DM attending public or private clinics in Brazil. Each investigator included the first 10 patients with type 2 DM who visited his/her office, and the first 5 patients with type 1 DM. Results A total of 1,358 patients were analyzed; 375 (27.6%) had type 1 and 983 (72.4%) had type 2 DM. Most individuals were women, Caucasian, and private health care users. High prevalence rates of hypertension, dyslipidemia and central obesity were observed, particularly in type 2 DM. Only 7.3% and 5.1% of the individuals with types 1 and 2 DM, respectively, had optimal control of blood pressure, plasma glucose and lipids. The absence of hypertension and female sex were associated with better control of type 1 DM and other cardiovascular risk factors. In type 2 DM, older age was also associated with better control. Conclusions Female sex, older age, and absence of hypertension were associated with better metabolic control. An optimal control of plasma glucose and other cardiovascular risk factors are obtained only in a minority of individuals with diabetes. Local numbers, compared to those from other countries are worse.

Silvio Rigutini, Brustbild

Signatur des Originals: S 36/F01641

Silvio Rigutini, Kniestück

Signatur des Originals: S 36/F01642

Silvio Rigutini, Brustbild

Signatur des Originals: S 36/F01643

Manual para la preservación de papel: nueva era de la conservación preventiva y su aplicación actualizada de Silvio Gorén

Fil: Pené, Mónica Gabriela. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Las aspiraciones de Silvio Astier : Fama, delito y lectura en El juguete rabioso de Roberto Arlt

El presente trabajo tiene por objetivo el estudio de El juguete rabioso de Roberto Arlt, partiendo de la perspectiva de la crítica genética y atendiendo a la importancia que reviste el sistemático análisis de los diferentes tipos de esbozos preparatorios de la novela de Arlt, dados a conocer como adelantos en revista literarias. Estos aspectos desarrollados aquí apuntan a reflexionar sobre las relaciones entre pre-texto y texto como modo de abordaje al estudio de la obra literaria y tienen como principal finalidad advertir las diferentes trasformaciones sufridas por Silvio Astier en distintas etapas de la composición del texto. Se atenderá fundamentalmente a las representaciones vacilantes que introduce Arlt, en relación con la lectura y el universo libresco, como así también las consideraciones en torno a la idea de reconocimiento literario y el lugar del delito

Manual para la preservación de papel: nueva era de la conservación preventiva y su aplicación actualizada de Silvio Gorén

Fil: Pené, Mónica Gabriela. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Las aspiraciones de Silvio Astier : Fama, delito y lectura en El juguete rabioso de Roberto Arlt

El presente trabajo tiene por objetivo el estudio de El juguete rabioso de Roberto Arlt, partiendo de la perspectiva de la crítica genética y atendiendo a la importancia que reviste el sistemático análisis de los diferentes tipos de esbozos preparatorios de la novela de Arlt, dados a conocer como adelantos en revista literarias. Estos aspectos desarrollados aquí apuntan a reflexionar sobre las relaciones entre pre-texto y texto como modo de abordaje al estudio de la obra literaria y tienen como principal finalidad advertir las diferentes trasformaciones sufridas por Silvio Astier en distintas etapas de la composición del texto. Se atenderá fundamentalmente a las representaciones vacilantes que introduce Arlt, en relación con la lectura y el universo libresco, como así también las consideraciones en torno a la idea de reconocimiento literario y el lugar del delito

Manual para la preservación de papel: nueva era de la conservación preventiva y su aplicación actualizada de Silvio Gorén

Fil: Pené, Mónica Gabriela. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.