Sistemas microemulsionados como carreador lipídico para fármacos insolúveis

Several pharmaceutical products have been developed in recent years aiming to enhance the treatment of diseases by increasing the effectiveness of drugs. Many of these new products are based on new drug delivery systems. Among these, microemulsions, which were first studied in 1943 by Hoar and Schulman, is of great interest. Microemulsion can be defined as a thermodynamically stable, isotropic, translucent and transparent system of two immiscible liquids stabilized by a surfactant film located in the oil / water interface. The aim os this work was the incorporation of Amphotericin B and Simvasatin to a microemulsion system and analyzes its physicochemical properties and their therapeutical activity when incorporated into this system. Some very promising results were achieved as the reduction of the toxicity and maintenance of the efficacy of the Amphotericin B incorpored into a microemulsion, which was demonstrated in the in vitro pharmacotoxicological study. As for the incorporation of Simvastatin in microemulsion, it was observed a significant improvement in the potential antiinflammatory and anti-infective properties when the system was use to treat infected wounds (simvastatin pleiotropic effects). Therefore, it can be concluded that the incorporation of these drugs into microemulsion system reveal the potential of microemulsions as a promising and novel dosage form, qualifying them for future trials in order to make them available in the pharmaceutical market

Scorpiodinipora costulata (Canu & Bassler, 1929) (Bryozoa, Cheilostomata), a taxonomic and biogeographic dilemma: complex of cryptic species or human-mediated cosmopolitan colonizer?

Despite implausible cosmopolitanism, the species Scorpiodinipora costulata (Canu & Bassler, 1929) has been attributed with reservations to small encrusting colonies with similar morphological features whose known distribution is scattered in tropical and subtropical seas: Pacific Ocean (Philippines), Indian Ocean (Oman), Red Sea, SE Mediterranean, SE Atlantic (Ghana) and SW Atlantic (Brazil). This material raised questions about its generic assignment. The genus Scorpiodinipora Balavoine, 1959 is redescribed with Schizoporella costulata Canu & Bassler, 1929, from the Philippines as the type species, as Balavoine misidentified the specimens to define the genus as Cellepora bernardii Audouin, 1826. Moreover, SEM examination of the cotypes of S. costulata showed that Canu & Bassler confused two genera among them. A lectotype and paralectorype were thus chosen from Canu & Bassler's syntypes corresponding with the present morphotype. Hippodiplosia ottomuelleriana var. parva Marcus, 1938, from Brazil, which presents the same morphotype, is provisionally considered as the junior synonym of S. costulata. Considering the broad allopatric distribution of this morphotype across the oceans and the low capacity of dispersal of species with short-lived larvae, it is likely that this material includes several sibling species. However, the role of man-mediated dispersal is not excluded, at least in regions with high shipping activity, such as that comprising the Suez Canal.

Can Jupiters be found by monitoring Galactic bulge microlensing events from northern sites?

In 1998 the EXPORT team monitored microlensing event light curves using a charge-coupled device (CCD) camera on the IAC 0.8-m telescope on Tenerife to evaluate the prospect of using northern telescopes to find microlens anomalies that reveal planets orbiting the lens stars. The high airmass and more limited time available for observations of Galactic bulge sources make a northern site less favourable for microlensing planet searches. However, there are potentially a large number of northern 1-m class telescopes that could devote a few hours per night to monitor ongoing microlensing events. Our IAC observations indicate that accuracies sufficient to detect planets can be achieved despite the higher airmass.

Joannis-Emmanuel Gilibert, olim in Collegio ... Exercitia phytologica quibus omnes plantae europaeae [sic], quas vivas invenit in variis herbationibus, seu in Lithuania, Gallia ... : [Texto impreso] volumen primum : plantae lithuanicae cum lugdunensibus comparatae

Tit. en antep.: "Supplementum systematis plantarum Europae"

Joannis-Emmanuel Gilibert, olim in Collegio ... Exercitia phytologica quibus omnes plantae europeae, quas vivas invenit in variis herbationibus, seu in Lithuania, Gallia ... : [Texto impreso] volumen secundum : caeterae plantae lithuanicae cum lugdunensibus comparatae

Tit. en antep.: "Supplementum systematis plantarum Europae"

General Charte der Laender Zwischen dem Schwarzen und Caspischen Meere: Circassien, Georgien, Armenien, Wüste von Astrachan und Caucasus hauptsoechlich die Grosse und Kleine Kabarda

Nach Russischen und and Handschriften entworsen Strasburg bey Joh. Georg Treuttel ; I. P. Kremer delin ; B. F. Leizelt sc.

Monumens de l'histoire de France, en estampes et dessins ...

The present 30 volumes seem to have remained with the Dukes of Leuchtenberg, until the ducal library was acquired for sale in 1935 by the dealers Ulrich Hoepli (Milan) and Braus-Riggenbach (Basel). The volumes are not complete, as leaves have been wholly or partly removed throughout; this is particularly evident in preliminary volumes 2 and 10 and volume 75. Prints and the relatively small number of drawings are mostly French, with some German, Dutch and English, and are mostly of the 17th or 18th centuries. They are mounted generally on rectos of leaves, often with hand-written captions. Large prints are occasionally bound in directly; these are often folded. The engraved general title page (bearing the date 1788) appears at the beginning of each volume; below the printed title a hand-written volume number and brief title describing the volume's contents usually appear. In many volumes the title leaf is followed by a hand-written contents leaf listing the section titles, which are also written individually throughout the volume on leaves with etched decorative frames. Sections are numbered continuously throughout the work as a whole. Numbering of the leaves, when present, appears in black ink within each volume at top center recto. Printmakers include B. & J. Audran, Francesco Bartolozzi, Abraham Bosse, Stefano della Bella, Jacques Callot, François Chéreau, Wenceslaus Hollar, Romeyn de Hooghe, Raymond La Fage, Sébastien Le Clerc, Pierre Lepautre, Claude Mellan, Bernard Picart, and Simon Thomassin. There are also early color prints by Gautier-Dagoty and Jean-Baptiste Morret.

Les Fours électriques industriels et les fabrications électrothermiques ... /

Mode of access: Internet.

Histoire de France depuis les Gaulois jusqu'à la mort de Louis XVI ;

Vol. 12: Table des matières [par J. L. J. Brière]

Observations sur les affections catarrhales en général, et paticulièrement sur celles connues sous les noms de rhumes de cerveau et de rhumes de poitrine /

Mode of access: Internet.