Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study

Chronic low-grade systemic inflammation is a key component in atherogenesis. Decreased heart rate variability (HRV), a strong predictor of cardiovascular events, has been associated with elevations in circulating levels of C-reactive protein (CRP), interleukin (IL)-6, and fibrinogen in apparently healthy individuals. We investigated whether decreased HRV is associated with inflammatory markers in patients with coronary heart disease (CHD).

Willy Loman and the "Soul of a New Machine": Technology and the Common Man

As Death of a Salesman opens, Willy Loman returns home “tired to the death” (p. 13). Lost in reveries about the beautiful countryside and the past, he's been driving off the road; and now he wants a cheese sandwich. But Linda's suggestion that he try a new American-type cheese — “It's whipped” (p. 16) — irritates Willy: “Why do you get American when I like Swiss?” (p. 17). His anger at being contradicted unleashes an indictment of modern industrialized America: The street is lined with cars. There's not a breath of fresh air in the neighborhood. The grass don't grow any more, you can't raise a carrot in the back yard. (p. 17). In the old days, “This time of year it was lilac and wisteria.” Now: “Smell the stink from that apartment house! And another one on the other side…” (pp. 17–18). But just as Willy defines the conflict between nature and industry, he pauses and simply wonders: “How can they whip cheese?” (p. 18). The clash between the old agrarian ideal and capitalistic enterprise is well documented in the literature on Death of a Salesman, as is the spiritual shift from Thomas Jefferson to Andrew Carnegie to Dale Carnegie that the play reflects. The son of a pioneer inventor and the slave to broken machines, Willy Loman seems to epitomize the victim of modern technology.

Plan de marketing. Runner Soul

La elaboración de un Plan de Marketing es fundamental para cualquier empresa del mercado. El presente trabajo analiza la situación de una empresa especializada en running, la cual comenzó su actividad hace un año. El motivo principal del trabajo es la incertidumbre de los propietarios, ya que éstos no realizaron ningún tipo de estudio antes de comenzar la actividad. El análisis es realizado a través de un plan de marketing estructurado en varias partes. Primero se presenta la empresa y se establece la misión y visión. Luego, se analiza la empresa externa e internamente, obteniendo la matriz DAFO1. A continuación, se establecen los objetivos a alcanzar por la empresa, así como las estrategias para alcanzarlos. Finalmente, se determinan las acciones a seguir para las cuatro variables del marketing mix y se realiza un análisis del presupuesto de la empresa, así como la previsión de beneficios mediante tres escenarios distintos, con el fin de obtener las conclusiones oportunas acerca del futuro de la empresa.

The Soul never sleeps, 1761

Three-page handwritten composition in English beginning, "One would think that by this Time our opponents should be pretty near silenced..." The document is a draft with edits and struck-through words and the verso includes the handwritten title, "Argument at a forensic Disputation 1761."

[Forensic dispute on thinking and the soul], undated

One folio-sized leaf containing a handwritten essay responding to an unidentified opponent's claims that "thinking is essential to the soul." The response begins with the introduction, "In the consideration of this question, I shall only examine one or two of the most material objects of our antagonist." The verso is inscribed: "2d Forensic. not read."

An essay on the universal plentiude of being and on the nature and immortality of the human soul and its agency : manuscript, [1784]

Autograph manuscript, signed, with autograph manuscript revisions.

A Global Strategy for a soul-searching European Union. EPC Discussion Paper, 13 July 2016

On 28 June 2016, just a few days after the historic Brexit vote, High Representative of the Union for Foreign Affairs and Security Policy Federica Mogherini presented the paper on the new European Union Global Strategy (EUGS) at the European Council, outlining the strategic coordinates for the EU’s foreign and security policy. In this Discussion Paper, Giovanni Grevi takes a closer look at the EUGS and assesses its main rationale, features, added value and prospects against the backdrop of an ever more complex world. Not only is the EU dealing with increasingly contested and polarised politics at home, but the global theatre itself has become hugely disorienting, more integrated and yet more fragmented at the same time. The paper recalibrates the overall foreign policy posture of the EU and sketches out a more modest and concrete approach compared to earlier aspirations, and a more joined-up one compared to current practice. By doing so, the strategy seeks to square the circle between the need for Europe to be cohesive and purposeful in a harder strategic environment and the fact that domestic politics within the Union constrain its external action and drain its attractiveness. The EUGS calls on the EU and member states to fully take on their responsibility to underpin unity, prosperity and security at home by taking more effective and joined-up action abroad. The question is, of course, whether this call will be heeded.