A Hierarchical Bayesian Model for Measuring Motion Adaptation

Previous research has shown that motion imagery draws on the same neural circuits that are involved in perception of motion, thus leading to a motion aftereffect (Winawer et al., 2010). Imagined stimuli can induce a similar shift in participants’ psychometric functions as neural adaptation due to a perceived stimulus. However, these studies have been criticized on the grounds that they fail to exclude the possibility that the subjects might have guessed the experimental hypothesis, and behaved accordingly (Morgan et al., 2012). In particular, the authors claim that participants can adopt arbitrary response criteria, which results in similar changes of the central tendency μ of psychometric curves as those shown by Winawer et al. (2010).

Adaptation and maladaptation of heart and skeletal muscle to different diets in a rodent model of human obesity

Obesity and diabetes are metabolic disorders associated with fatty acid availability in excess of the tissues' capacity for fatty acid oxidation. This mismatch is implicated in the pathogenesis of cardiac contractile dysfunction and also in skeletal muscle insulin resistance. My dissertation will present work to test the overall hypothesis that "western" and high fat diets differentially affect cardiac and skeletal muscle fatty acid oxidation, the expression of fatty acid responsive genes, and cardiac contractile function. Wistar rats were fed a low fat, "western," or high fat (10%, 45%, or 60% calories from fat, respectively) diet for acute (1 day to 1 week), short (4 to 8 weeks), intermediate (16 to 24 weeks), or long (32 to 48 weeks) term. With high fat diet, cardiac oleate oxidation increased at all time points investigated. In contrast, with western diet cardiac oleate oxidation increased in the acute, short and intermediate term, but not in the long term. Consistent with a maladaptation of fatty acid oxidation, cardiac power (measured ex vivo) decreased with long term western diet only. In contrast to the heart, soleus muscle oleate oxidation increased only in the acute and short term with either western or high fat feeding. Transcript analysis revealed that several fatty acid responsive genes, including pyruvate dehydrogenase kinase 4, uncoupling protein 3, mitochondrial thioesterase 1, and cytosolic thioesterase 1 increased in heart and soleus muscle to a greater extent with high fat diet, versus western diet, feeding. In conclusion, the data implicate inadequate induction of a cassette of fatty acid responsive genes in both the heart and skeletal muscle by western diet resulting in impaired activation of fatty acid oxidation, and the development of cardiac dysfunction. ^

Adaptation of the Bolivia community postabortion care model in Egypt and Peru

La implementación del modelo de la comunidad del PAC en los tres países demuestra que el modelo es adaptable a diferentes niveles, en diferentes configuraciones y en una variedad de contextos socioculturales. Con el fin de efectuar cambios positivos, es importante para crear comunidades fuertes y unidas como fuerza motriz del cambio en el tratamiento de temas relacionados con las complicaciones del aborto involuntario e incompleto

Designing new cereal cultivars as an adaptation measure using crop model ensembles

To date, crop models have been little used for characterising the types of cultivars suited to a changed climate, though simulations of altered management (e.g. sowing) are often reported. However, in neither case are model uncertainties evaluated at the same time.

A model of excitation and adaptation in bacterial chemotaxis

Bacterial chemotaxis is widely studied because of its accessibility and because it incorporates processes that are important in a number of sensory systems: signal transduction, excitation, adaptation, and a change in behavior, all in response to stimuli. Quantitative data on the change in behavior are available for this system, and the major biochemical steps in the signal transduction/processing pathway have been identified. We have incorporated recent biochemical data into a mathematical model that can reproduce many of the major features of the intracellular response, including the change in the level of chemotactic proteins to step and ramp stimuli such as those used in experimental protocols. The interaction of the chemotactic proteins with the motor is not modeled, but we can estimate the degree of cooperativity needed to produce the observed gain under the assumption that the chemotactic proteins interact directly with the motor proteins.

Providing Bereavement Counseling to Chinese Americans: A Cultural Adaptation of a Western Grief Counseling Model.

The aim of this paper is to extend the existing literature and propose an alternative perspective on bereavement counseling with Chinese Americans. This aim is achieved by integrating William Worden's (2009) grief counseling model with several cultural components that are relevant to counseling with Chinese Americans, including: (a) the barriers to seeking counseling, (b) the clinical presentations of Asian Americans, (c) the common coping styles among Asian Americans, (d) the major Chinese religions and philosophies, and (e) the bereavement-related cultural practices. The corresponding treatment recommendations will be explored following the discussion of each cultural element. Finally, a culturally responsive grief counseling model for Chinese Americans will be proposed in the last section, along with a discussion of important caveats.

Corporate strategies of automotive manufacturers. Volume IV: adaptation of a computer simulation model of the industry. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Operator's manual : tractor, wheeled (DED) loader backhoe w/hydraulic impact tool and w/hydraulic earth auger attachment, John Deere model JD410 (CCE), w/Wain-Roy Bucket, Hughes Impactor and Danuser Earth Drill, (NSN 2420-00-567-0135).

Includes index.

Organizational maintenance manual : tractor, wheeled (DED) loader backhoe w/hydraulic impact tool and w/hydraulic earth auger attachment, John Deere model JD410 (CCE), w/Wain-Roy Bucket, Hughes Impactor and Danuser Earth Drill, (NSN 2420-00-567-0135).

Includes indexes.

Adaptation to being at-risk for Huntington's disease and the availability of genetic testing: Application of a stress and coping model

This study examined the utility of a stress/coping model in explaining adaptation in two groups of people at-risk for Huntington's Disease (HD): those who have not approached genetic testing services (non-testees) and those who have engaged a testing service (testees). The aims were (1) to compare testees and non-testees on stress/coping variables, (2) to examine relations between adjustment and the stress/coping predictors in the two groups, and (3) to examine relations between the stress/coping variables and testees' satisfaction with their first counselling session. Participants were 44 testees and 40 non-testees who completed questionnaires which measured the stress/coping variables: adjustment (global distress, depression, health anxiety, social and dyadic adjustment), genetic testing concerns, testing context (HD contact, experience, knowledge), appraisal (control, threat, self-efficacy), coping strategies (avoidance, self-blame, wishful thinking, seeking support, problem solving), social support and locus of control. Testees also completed a genetic counselling session satisfaction scale. As expected, non-testees reported lower self-efficacy and control appraisals, higher threat and passive avoidant coping than testees. Overall, results supported the hypothesis that within each group poorer adjustment would be related to higher genetic testing concerns, contact with HD, threat appraisals, passive avoidant coping and external locus of control, and lower levels of positive experiences with HD, social support, internal locus of control, self-efficacy, control appraisals, problem solving, emotional approach and seeking social support coping. Session satisfaction scores were positively correlated with dyadic adjustment, problem solving and positive experience with HD, and inversely related to testing concerns, and threat and control appraisals. Findings support the utility of the stress/coping model in explaining adaptation in people who have decided not to seek genetic testing for HD and those who have decided to engage a genetic testing service.

Blur adaptation explained by a norm-based model of contrast adaptation

Adapting to blurred images makes in-focus images look too sharp, and vice-versa (Webster et al, 2002 Nature Neuroscience 5 839 - 840). We asked how such blur adaptation is related to contrast adaptation. Georgeson (1985 Spatial Vision 1 103 - 112) found that grating contrast adaptation followed a subtractive rule: perceived (matched) contrast of a grating was fairly well predicted by subtracting some fraction k(~0.3) of the adapting contrast from the test contrast. Here we apply that rule to the responses of a set of spatial filters at different scales and orientations. Blur is encoded by the pattern of filter response magnitudes over scale. We tested two versions - the 'norm model' and 'fatigue model' - against blur-matching data obtained after adaptation to sharpened, in-focus or blurred images. In the fatigue model, filter responses are simply reduced by exposure to the adapter. In the norm model, (a) the visual system is pre-adapted to a focused world and (b) discrepancy between observed and expected responses to the experimental adapter leads to additional reduction (or enhancement) of filter responses during experimental adaptation. The two models are closely related, but only the norm model gave a satisfactory account of results across the four experiments analysed, with one free parameter k. This model implies that the visual system is pre-adapted to focused images, that adapting to in-focus or blank images produces no change in adaptation, and that adapting to sharpened or blurred images changes the state of adaptation, leading to changes in perceived blur or sharpness.

Response normalization and blur adaptation:data and multi-scale model

Adapting to blurred or sharpened images alters perceived blur of a focused image (M. A. Webster, M. A. Georgeson, & S. M. Webster, 2002). We asked whether blur adaptation results in (a) renormalization of perceived focus or (b) a repulsion aftereffect. Images were checkerboards or 2-D Gaussian noise, whose amplitude spectra had (log-log) slopes from -2 (strongly blurred) to 0 (strongly sharpened). Observers adjusted the spectral slope of a comparison image to match different test slopes after adaptation to blurred or sharpened images. Results did not show repulsion effects but were consistent with some renormalization. Test blur levels at and near a blurred or sharpened adaptation level were matched by more focused slopes (closer to 1/f) but with little or no change in appearance after adaptation to focused (1/f) images. A model of contrast adaptation and blur coding by multiple-scale spatial filters predicts these blur aftereffects and those of Webster et al. (2002). A key proposal is that observers are pre-adapted to natural spectra, and blurred or sharpened spectra induce changes in the state of adaptation. The model illustrates how norms might be encoded and recalibrated in the visual system even when they are represented only implicitly by the distribution of responses across multiple channels.

Model-driven software adaptation:report on the workshop M-ADAPT at ECOOP 2007

This first edition of the workshop Model-driven Software Adaptation (M-ADAPT'07) took place in the Technische Universität Berlin with the International Conference ECOOP'07 in the beautiful and buzzing city of Berlin, on the 30th of July, 2007. The workshop was organized by Gordon Blair, Nelly Bencomo, and Robert France. Participants explored how to develop appropriate model-driven approaches to model, analyze, and validate the volatile properties of the behaviour of adaptive systems and its environments. This report gives an overview of the presentations as well as an account of the fruitful discussions that took place at M-ADAPT'07. © 2008 Springer-Verlag Berlin Heidelberg.

Run-time model evaluation for requirements model-driven self-adaptation

A self-adaptive system adjusts its configuration to tolerate changes in its operating environment. To date, requirements modeling methodologies for self-adaptive systems have necessitated analysis of all potential system configurations, and the circumstances under which each is to be adopted. We argue that, by explicitly capturing and modelling uncertainty in the operating environment, and by verifying and analysing this model at runtime, it is possible for a system to adapt to tolerate some conditions that were not fully considered at design time. We showcase in this paper our tools and research results. © 2012 IEEE.