910 resultados para Power, Eugene B., 1905-
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B. Hirsch
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B. Hirsch
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B. Hirsch
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B. Goldberg
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B. Samuel
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B. Hahn
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B. Goldberg
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B. Goldberg
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B. Goldberg
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The MDR1 P-glycoprotein (Pgp), a member of the ATP-binding cassette family of transporters, is a transmembrane ATPase efflux pump for various lipophilic compounds, including many anti-cancer drugs. mAb UIC2, reactive with the extracellular moiety of Pgp, inhibits Pgp-mediated efflux. UIC2 reactivity with Pgp was increased by the addition of several Pgp-transported compounds or ATP-depleting agents, and by mutational inactivation of both nucleotide-binding domains (NBDs) of Pgp. UIC2 binding to Pgp mutated in both NBDs was unaffected in the presence of Pgp transport substrates or in ATP-depleted cells, whereas the reactivities of the wild-type Pgp and Pgps mutated in a single NBD were increased by these treatments to the level of the double mutant. These results indicate the existence of different Pgp conformations associated with different stages of transport-associated ATP hydrolysis and suggest trapping in a transient conformation as a mechanism for antibody-mediated inhibition of Pgp.
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The reports, each with special t.-p., included in this work, have been issued also separately.
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Decision of Chief Justice Taney in the Merryman case on the writ of Habeas Corpus.--The privilege of the writ of Habeas Corpus under the Constitution.--Presidential power over personal liberty. A review of Horace Binney's essay on the writ of Habeas Corpus.--Reply to Horace Binney on the privilege of the writ of habeas corpus under the Constitution.--A review of Mr. Binney's pamphlet on the privilege of the writ of habeas corpus under the Constitution, by J. C. Bullitt.--The privilege of the writ of habeas corpus under the Constitution of the United States.--The suspending power and the writ of habeas corpus.--An undelivered speech on executive arrests.--Executive power, by B. R. Curtis.
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"Issued August 1953" -- p. 1.
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Includes the texts of the original bulls, decrees, and instructions that are basic to a study of the patronage.
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Mode of access: Internet.