Traducción de privilegios del Gremio de Texedores de Seda y Velos de esta ciudad, del idioma latin y valenciano al castellano , 1484-1626 [Manuscrito]

Contiene la traducción de los siguientes privilegios: I. Traslado de la sentencia que obtuvo el oficio de tejedores de seda contra los arrendadores del derecho de mercadería de esta ciudad, sobre no pagar derecho de imposición.13-02-1484. Fol 2 v-10. II. Indulto concedido por Carlos I al oficio de veleros y confirmación de privilegios concedidos por los Reyes de Aragón. 20-08-1524. Fol 10-21. III. Privilegio del Rey Felipe II en confirmación de otro del Rey D. Juan II de Aragón dado en Monzón el 20 de febrero de 1470, sobre las Ordenanzas del gremio de veleros. 22-03-1564. IV. Privilegio del rey Felipe III en confirmación de los concedidos anteriormente al oficio de tejedores de sedas y velos por sus antecesores. 18-02-1604. Fol 31 v.-44. V. Privilegio concedido por el rey Felipe IV en confirmación de los concedidos al oficio de tejedores de seda y velos por sus antecesores. 12-04-1626. Fol 44-60.

Las obras y relaciones de Antonio Perez, secretario de Estado que fue del Rey de España, Don Phelippe Secondo ...

Contiene: Relaciones de Antonio Pérez -- El memorial que Antonio Pérez presente del hecho de su causa -- Aphorismos del libro de las relaciones de Antonio Pérez -- Cartas de Ant. Pérez -- Epistola prima Antonius Perezius -- Aphorismos de las cartas espannolas y latinas de Ant. Pérez -- Segundas cartas de Antonio Pérez -- Aphorismos de las segundas cartas de Ant. Pérez -- Cartas de Antonio Pérez a Donna Ioanna Coello, su muger, y a sus hijos

Carta de SS.MM. la Reina y el Rey al Excmo. Sr. Ministro de Fomento sobre la educacion de S.A.R. el Sermo. Sr. Principe de Asturias /

Mode of access: Internet.

Manifesto e allegação juridica, critica, e apologetica, a favor dos professores da faculdade de leys, sobre o direyto que lhes compete para serem providos em os canonicatos doutoraes das sés deste reyno de Portugal, e Algarve /

en p. i-iv,

Análise do contributo das acessibilidades rodoviárias para o desenvolvimento regional: o caso da Nut II do Centro

Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Civil na Área de Especialização em Vias de Comunicação e Transportes

Estudio, edición crítica y traducción del "Memoriale virtvtvm" de Alfonso de Cartagena

Alfonso de Cartagena (1385-1456), possibly the most representative figure of the courtly, political and cultural dimension built around Juan II, was the third son of the famous convert Pablo de Santa Maria, Burgos’ rabbi and, later on, bishop of that same town. He started his career as governor of Cartagena’s cathedral, afterwards he was named dean of Santiago and Segovia, canon of Burgos and, after his father’s death, bishop of Burgos. Alternatively, he played a vital role in Castile’s national and international politics, as an ambassador in Portugal���s court, at Basel’s council and before Poland’s and Germany’s kings. His work, written both in Latin and Romance, either as an historian, treatise writer, theologist or translator, is quite broad; his literary connections were strong either with Italian humanists or with those who were fond of the language arts from Spain. The first part of this Thesis seeks to provide a wide enough perspective of the author, for which we place the emphasis on the most distinctive aspects of his life. Therefore, we divided the introduction in three sections: a biographical overview, his work and, last, a study on the Memoriale uirtutum itself. Thus, regarding the first aspect, we focus on the course of his life (§1.1), where we can highlight his university education, which isn’t restricted to his training as a jurist, but we also observe that his mental vitality takes him to develop certain inquisitiveness for Moral Philosophy or Latin, which leads him to study Grammar and Rhetoric; this would allow the influence of studia humanitatis to emerge, although he never got to learn the Greek language, as we can deduce from the epistolary confrontation between him and Leonardo Bruni. We also focus on the significance of his Jewish past, upon the defence of the converts during the massacre experienced in the XVth century (§1.2), and on his presence at Basel’s council (§1.3). Despite the fact that his work as a diplomat begins during the missions in Portugal as an emissary of king Juan II, he will get recognition owing to his legation in Basel, not only among the European ecclesiastics, but also among the scholars from Italy; the importance of Basel’s council in Cartagena’s life goes beyond his official work there, either as defending the Castilian interests, or as an active member of the purely conciliar functions, since it also had a huge impact in his intellectual growth. During this time period, Cartagena establishes a friendship with Pizzolpaso, Bishop of Milan, writer, humanist, and friend of Leonardo Bruni. As a result of this type of relationship with men of such high cultural standard, he re-awakens the study of the Classical antiquity among his contemporaries, developing a huge interest in the Greco-Roman masterpieces, which will bring him closely to the highly-regarded Spanish humanists of the XVIth century...

Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1.

Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of view, MS is a complex disorder resulting from the combination of genetic and non-genetic factors. We aimed to identify previously unidentified loci conducting a new GWAS of Multiple Sclerosis (MS) in a sample of 296 MS cases and 801 controls from the Spanish population. Meta-analysis of our data in combination with previous GWAS was done. A total of 17 GWAS-significant SNPs, corresponding to three different loci were identified:HLA, IL2RA, and 5p13.1. All three have been previously reported as GWAS-significant. We confirmed our observation in 5p13.1 for rs9292777 using two additional independent Spanish samples to make a total of 4912 MS cases and 7498 controls (ORpooled = 0.84; 95%CI: 0.80-0.89; p = 1.36 × 10-9). This SNP differs from the one reported within this locus in a recent GWAS. Although it is unclear whether both signals are tapping the same genetic association, it seems clear that this locus plays an important role in the pathogenesis of MS.