Concrete houses & cottages ...

I. Large houses.--II. Small houses.

Examples of labourers' cottages, etc. with plans for improving the dwellings of the poor in large towns.

Mode of access: Internet.

Picturesque architectural studies and practical designs for gate lodges, cottages, cottage hospitals, villas, vicarages, country residences, schools, village churches, etc., etc,

Mode of access: Internet.

Parnell movement : being the history of the Irish question from the death of O'Connell to the present time /

Photocopy.

The architecture of country houses : including designs for cottages, farm houses, and villas, with remarks on interiors, furniture, and the best modes of warming and ventilating. /

Many of the illustrations engraved by Anderson.

The poetical works of Dr. Tho. Parnell.

Mode of access: Internet.

The posthumous works of Dr. Thomas Parnell ... : containing poems moral and divine: and on various other subjects.

Head- and tail-piece.

Old cottages and farmhouses in Kent and Sussex

Mode of access: Internet.

Cottages; or, Hints on economical building, containing twenty-four plates of medium and low cost houses, contributed by different New York architects. Together with descriptive letterpress, giving practical suggestions for cottage building.

Mode of access: Internet.

Wine Cask Cottages

Builders competed with each other in constructing cottages with visual appeal. Vacation rentals designed to look like wine casks, seen here in the 1930s and 1940s were available on the shoreline between Vermilion and Huron, Ohio and on South Bass Island in Lake Erie.

Aboriginal cottages, transactional encounters and mission lifestyles at New Norcia, 1860-1900s

Several photos of Aboriginal people outside their cottages exist in the New Norcia Archives. These images could be read in different ways but have commonly been viewed as powerfully symbolic stories of successful mission life and converted Aboriginal people. While historians of colonial photography have persuasively linked the photographs of ‘settled’ Aboriginal residents with evidence of missionary success, we might add that they could also be compelling proof of Aboriginal families’ own success in adapting their land use and way of life in the context of dispossession. Reading this photograph of Aboriginal houses alongside Aboriginal voices in New Norcia’s archive it is possible to suggest Aboriginal people’s own desires for houses and settlement aligned with their ideas about respectability, as well as Aboriginal families’ own complicity in mission propaganda through such images.

The MS risk allele of CD40 is associated with reduced cell-membrane bound expression in antigen presenting cells: Implications for gene function

Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development of multiple sclerosis (MS). We investigated the cell specific gene and protein expression variation controlled by the CD40 genetic variant(s) associated with MS, i.e. the T-allele at rs1883832. Previously we had shown that the risk allele is expressed at a lower level in whole blood, especially in people with MS. Here, we have defined the immune cell subsets responsible for genotype and disease effects on CD40 expression at the mRNA and protein level. In cell subsets in which CD40 is most highly expressed, B lymphocytes and dendritic cells, the MS-associated risk variant is associated with reduced CD40 cell-surface protein expression. In monocytes and dendritic cells, the risk allele additionally reduces the ratio of expression of full-length versus truncated CD40 mRNA, the latter encoding secreted CD40. We additionally show that MS patients, regardless of genotype, express significantly lower levels of CD40 cell-surface protein compared to unaffected controls in B lymphocytes. Thus, both genotype-dependent and independent down-regulation of cell-surface CD40 is a feature of MS. Lower expression of a co-stimulator of T cell activation, CD40, is therefore associated with increased MS risk despite the same CD40 variant being associated with reduced risk of other inflammatory autoimmune diseases. Our results highlight the complexity and likely individuality of autoimmune pathogenesis, and could be consistent with antiviral and/or immunoregulatory functions of CD40 playing an important role in protection from MS. © 2015 Field et al.