Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.

Tarjolla itkua ja kyyneleitä - ja haastavia tutkimusaineistoja

Kolumni

Ikääntyvät 1990-luvun Virossa: selviytyminen työssä ja elämässä

Summary: Elderly people in Estonia in the 1990s: works and coping

Risk Management or Uncertainty Governance? The Challenge of an Interdiscplinary Approach

Peer-reviewed

Alimento humano : viabilidad y encaje del diseño permacultural como sistema agrícola

La Permacultura, los Paisajes de retención de agua y la Economía del bien común, se configuran como una alternativa a la situación actual de la agricultura. Mediante la combinación de estas corrientes, se puede desarrollar una agricultura más respetuosa con el entorno natural capaz de ayudar a regenerarlo. Una buena gestión del suelo fija y estabiliza el CO2 y gracias a los paisajes de captación de agua, se consigue cosechar el agua, infiltrándose en los ecosistemas y llenándolos de vida. Sumado a una correcta gestión del agua se mitigan los efectos del cambio climático en nuestras latitudes. Finalmente la economía del bien común, nos permite crear sistemas económicos más justos y sociales, encajando a la perfección con los principios de la Permacultura. Para poder aplicar dicho concepto actualmente, establecer el sistema agrícola como un sistema asociativo (asociación sin ánimo de lucro), nos permite fijar unos precios estables y sociales, dando especial importancia a la mano de obra y a la autosuficiencia.

Kirjaesittely

Kirjallisuusarvostelu