Integrating strategic and sustainable design approach for innovation process: a cement case study

Global society and technology have changed the relationships of the market. Quality and cost are not the main aspects of any industrial product. On the other hand, design, innovation and sustainability became significant requirements to company’s competitiveness. In this context, the design approach has shown evolutions, integrating social and environmental aspects beside traditional aspects such as technical and economic. Still, design has been becoming a strategic opportunity for companies, improving their competitiveness and increasing their market share. Thus, this research has analyzed the integration of both the Sustainable Design and Strategic Design Coaching (SDC) method in the making decision activities of companies. A cement company (BQMIL) was assigned as case study, in which the previous results have pointed out the significant hole of those concepts to generate Eco-innovation and Eco-Brand to increase its market share, corroborating the expectative of the design team

Effects of uracil calculi on cell growth and apoptosis in the BBN- initiated Wistar rat urinary bladder mucosa

The different potential of initiated and non-initiated urinary bladder mucosa (UBM) to develop neoplasia was quantitatively evaluated in the male Wistar rat. Initiation of carcinogenesis was accomplished with N-butyl-N-(4- hydroxybutyl)-nitrosamine (BBN). Stimuli for cell proliferation and apoptosis were obtained by exposure followed by withdrawal of 3% Uracil in the diet. The proliferation index (PI) was estimated in UBM immunostained for the proliferating nuclear cell antigen (PCNA). The apoptotic index (AI) and the density of papillary/nodular hyperplasia (PNH) were estimated in hematoxilin- eosin stained sections. PNH was the main proliferative response to the mechanical irritation by uracil, irrespective of previous initiation with BBN. Uracil exposure induced higher PI and PNH density in the initiated rats. After uracil withdrawal, there was a significant increase of the AI in both uracil-treated groups, which correlated well to the respective PNH density. However, at the end of the experiment, PNH incidence and density were significantly higher in the BBN-initiated mucosa, which also presented 18% incidence of papillomas and 27% of carcinomas. Therefore, under prolonged uracil calculi trauma, the UBM of BBN-initiated Wistar rats gives rise to epithelial proliferative lesions that progress to neoplasia through acquired resistance to apoptosis.

Dr. Edward (Ted) Elliot Eulogy

Kathy and Susie, members of the faculty, and staff of the School of Natural Resource Sciences, ladies and gentlemen. There are some things in this world that, try as we may, just cannot be adequately accomplished. One of those things, for me at least, is to express adequately what I feel about the passing of Dr. Edward (Ted) Elliot. Ted came to this University of Nebraska a few months before I arrived, and it was my distinct honor to count him among my friends at this great University. Ted was a man of exceptional scientific standing and wisdom, and his loss leaves a void in all of our lives that will not be readily filled.

Structural and procedural properties important in promoting bio-enterprises as alternative livelihoods to pastoral and agro-pastoral livelihoods

Alternative livelihoods to pastoral and agro-pastoral livelihoods are increasingly gaining attention in rural development but few empirical evidence exist on how to go about supporting such initiatives. As pastoral and agro-pastoral production conditions change due to various factors including market conditions, climate variability and change, pastoralists and agro-pastoralists are increasingly faced with the challenge of finding alternative livelihoods. Bio-enterprises offer such alternatives or complementary activities for rural actors to adapt to changing socio-ecological conditions. This study examines the roles of bio-enterprise initiatives from a livelihood perspective and identifies the features important for such initiatives to reduce poverty and improve the adaptive capacities of pastoralists and agro-pastoralists. It draws on four different bio-enterprise initiatives on agro-pastoral and pastoral livelihoods and on improved natural resources management (NRM) in the drylands of Kenya. Data were collected through interviews, focus group discussions, informal discussions and the study of reports. Results shows among other factors that diversification into enterprises requires cooperation among the stakeholders with their varying experiences in development, NRM and business development. Other factors such as sustained financial support, capacity development to survive the market introduction phase, as well as quantity and quality of the product, are critical. Mentoring proved to be a driver of success in some initiatives.

[Localised rhabdomyosarcoma of the extremities in children and adolescents: results of the French experience]

PATIENTS AND METHODS: Forty-six patients with localised RMS of the limbs entered the MMT 89 and 95 study in France. We studied potential risk factors that were predictive of relapse and survival to propose a therapeutic approach of surgery and radiotherapy appropriate to the risk of relapse. RESULTS: Median age at diagnosis was 6.5 years [9 months to 15.5 years]. At time of diagnosis, 43% had marginal surgery and only 13% radical intervention. Primary re-excision was performed in 12% of the patients. All patients received chemotherapy, 43% had second look surgery and 37% received radiotherapy. Fifty-four percent of all tumors relapsed: local relapse 36%, nodes l8%, metastatic 40%, local and metastatic 16%. Estimated overall 5-year event-free survival (EFS) and overall survival (OS) were 40 and 57%, respectively. CONCLUSIONS: Prognosis of RMS of the limbs is bad but only 37% of the patients had radiotherapy. We could define patients with very high risk among those with limbs RMS as nodal involvement (5 years overall survival OS 22%), alveolar histology (OS 38%) and site of hand and foot (4 survivors out of 10 patients). In further studies, these patients should be treated even more aggressive with early surgery followed by re-excision if necessary, chemotherapy including alkylating agents and systematic radiotherapy.

The struggle to diversify rural livelihoods: Bio-enterprise development initiatives and their impacts on agro-/pastoral communities in the drylands of Kenya

This article analyses the impacts of four different bio-enterprise initiatives on agro-pastoral livelihoods and on improved natural resources management (NRM) in the drylands of Kenya. In this way it contributes to an area of rural development that is gaining increasing interest, but still has little empirical evidence. Data were collected through interviews, focus group discussions, informal discussions and the study of reports. One of the key findings of this article is that diversification into enterprises requires cooperation among the stakeholders with their varying experiences in development, NRM and business development. In addition to initial investments, such enterprises need sustained financial, as well as other support like capacity development to survive the market introduction phase. For such enterprises to defend their market niches, the quantity and quality of the product are critical. In addition to support in human, financial, social, physical and natural capital, mentoring is another crucial factor for success.

Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition

Pax proteins, characterized by the presence of a paired domain, play key regulatory roles during development. The paired domain is a bipartite DNA-binding domain that contains two helix–turn–helix domains joined by a linker region. Each of the subdomains, the PAI and RED domains, has been shown to be a distinct DNA-binding domain. The PAI domain is the most critical, but in specific circumstances, the RED domain is involved in DNA recognition. We describe a Pax protein, originally called Lune, that is the product of the Drosophila eye gone gene (eyg). It is unique among Pax proteins, because it contains only the RED domain. eyg seems to play a role both in the organogenesis of the salivary gland during embryogenesis and in the development of the eye. A high-affinity binding site for the Eyg RED domain was identified by using systematic evolution of ligands by exponential enrichment techniques. This binding site is related to a binding site previously identified for the RED domain of the Pax-6 5a isoform. Eyg also contains another DNA-binding domain, a Prd-class homeodomain (HD), whose palindromic binding site is similar to other Prd-class HDs. The ability of Pax proteins to use the PAI, RED, and HD, or combinations thereof, may be one mechanism that allows them to be used at different stages of development to regulate various developmental processes through the activation of specific target genes.

1988 UM Women's Tennis Team

School of Nursing Class of 1981

Top Row: Mary Jo Ambrozy, Carolyn, Ashley, Gail Marie Barbaza, Jeanne Barr, Susan Bauer, Lynn Eva Becker, Christine Bibilikow, Kathy Biehl, Lisa Bloomfield, Bail M. Borowiak, Susan, M. Browning, Diane Louise Burgoon, Camille Carlson, Cindy marie Chaltry, Kathleen Anne Clegg, Ann cline

Row 2: Wendy Cogan, Annette Robin Cole, Barbara Compton, Elizabeth Connors, Norma K. Marshall, Michele Betts, Donna Jean Holihan, Pamela S. Harden, Kathleen McLaughlin, Mary M. Walker, Mary Lohr, Julia Cooney, Carol Crapo, Deborah D. Davis, Mary Dreisig

Row 3: Athena Eary, Eleanor Eckrich, Patti M. Eidenberger, Catherine Elmlinger, Annette Englund, Cynthis Fellencer, Karen Fischer, Carolyn B. Forbes, Nancy Ellen Freedman, Susan P. George, Annette Gervaix, Beverly Glogowski

Row 4: Jayne Goodrich, June A. R. Grimm, Marie Guerrini, Douglas Leon Hankins, Yvonne M. Harwoor, Linda Hecimovich, Catherine M. Herbel, Kelly Hocker, Brenda Lee Horness, Theresa A. Hosey, Karin E. Hunt, Beth Jackson

Row 5: Karen Sue Jaffe, Roland Jemerson, Tamera Johnson, Susan Kaczmarek, Laura S. Keverian, Julie A. Kimbrough, Eva Marie Kline, Nancy L. Kuehn, Margaret J. Labadie, Lori K. Lane, Elizabeth Lang, Linda Lawton, Judy Linden, Peggy Little, Sharon Lois Longe, Claire Lonstein

Row 6: Deloris Macon, Karen Marie Macsay, Susan E. Mapley, Maria Y. Maquera, Ann McCullough, Michael Meade, Barbara Messink, Mary Elizabeth Mick, Susie E. Mikolajewski, Marilyn Millman, Debra A. Mills, Lu Ann Minore, Jean M. Mischel, Terri Ann Mitchell, Catherine Jean Moore, Michelle A. Mourad

Row 7: Mary Lynn Musial, Kathleen Myles, Denise Oliphint, Patrice M. Orlowski, Susan Orne, Carolyn Pernell, Holly Perry, Paula L. Petkoff, Arlene Ann Popovich, Barbara A. Quinn, Carol Reid, Sandra J. Remington, Gisselle Rodriguez, Susan Roelant, Laura S. Rogers, Nancy Rudd

Row 8: Karen Beth Salem, Barbara Santavy, Linda Schairer, Marie B. Schneider, Julie Schoettley, Julie Rose Schuster, Mary V. Seibert, Tracy Shafer, Claire E. Sharda, Susan D. Shortino, Judith Simon, Phillis Simpson, Donna Sledz, Cynthia Smith, Diane L. Smith, Mary Kay Smith

Row 9: Susan R. Smith, Sharon stansberry, Linda Suchocki, Susan Swoiskin, Leslie Ann Urban, Mary B. Van Wingen, Gretchen M. Vermeulen, Verland Z. Walker, Jayne Walworth, Elaine Devorah Webber, Julie Ann Webster, Sora Weller, Julie L. Weyburne, Malorie Whitefield, Frances Wiecha, Anne C. Wise