Early adversity and 5-HTT-BDNF genes: New evidences of Gene-Environment interactions on depressive symptoms in a general population

Background Adverse childhood experiences have been described as one of the major environmental risk factors for depressive disorder. Similarly, the deleterious impact of early traumatic experiences on depression seems to be moderated by individual genetic variability. Serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) modulate the effect of childhood adversity on adult depression, although inconsistencies across studies have been found. Moreover, the gene×environment (G×E) interaction concerning the different types of childhood adversity remains poorly understood. The aim of this study was to analyse the putative interaction between the 5-HTT gene (5-HTTLPR polymorphism), the BDNF gene (Val66Met polymorphism) and childhood adversity in accounting for adult depressive symptoms. Method A sample of 534 healthy individuals filled in self-report questionnaires of depressive symptomatology [the Symptom Check List 90 Revised (SCL-90-R)] and different types of childhood adversities [the Childhood Trauma Questionnaire (CTQ)]. The 5-HTTLPR polymorphism (5-HTT gene) and the Val66Met polymorphism (BDNF gene) were genotyped in the whole sample. Results Total childhood adversity (β=0.27, p<0.001), childhood sexual abuse (CSA; β=0.17, p<0.001), childhood emotional abuse (β=0.27, p<0.001) and childhood emotional neglect (β=0.22, p<0.001) had an impact on adult depressive symptoms. CSA had a greater impact on depressive symptoms in Met allele carriers of the BDNF gene than in the Val/Val group (F=5.87, p<0.0001), and in S carriers of the 5-HTTLPR polymorphism (5-HTT gene) (F=5.80, p<0.0001). Conclusions Childhood adversity per se predicted higher levels of adult depressive symptoms. In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed to moderate the effect of CSA on adult depressive symptoms.

Chapman family group on porch, New Year's Day, 1929-1930

Chapman family group on porch, New Year's Day, 1929-1930. Written on back: "Father, Mother, Sister, with Jim, his wife and daughter."

On the generic identity of Odontophrynus moratoi Jim & Caramaschi, 1980 (Anura, Cycloramphidae)

The generic identity of Odontophrynus moratoi is controversial since the original description due to the presence of intermediate morphological features between the genera Odontophrynus and Proceratophrys. Herein we performed molecular analyses of three genes (16S, cyt b and Rag-1) and recovered O. moratoi deeply imbedded inside a clade containing only Proceratophrys species, appearing as the sister group of Proceratophrys concavitympanum. Therefore, this study formally transfers the species O. moratoi to the genus Proceratophrys [Proceratophrys moratoi (Jim & Caramaschi 1980) comb. nov].

Variação populacional de Proceratophrys moratoi (Jim e Caramashi, 1980) (Amphibia: Anura) no Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A NEW “PAROTRAP” ADAPTED FROM THE MAC TRAP FOR CAPTURING LIVE PARAKEETS IN THE FIELD

The Rose-ringed parakeet (Psittacula krameri [Scopdi]) has been reported (Roberts, 1974; Bashir, 1978; Beg, 1978; and DeGrazio, 1978) as a serious bird pest of maize, sunflower, rape seeds, and fruit crops, particularly citrus, mangoes, and guavas, in Pakistan. Estimated annual losses to maize grown for seed alone amount to about 97,000 tons, worth about Pak. Rs. 150 million or US $15 million (Roberts, 1978). Paradoxically, this handsome bright green parakeet is highly esteemed in the pet trade; and limited numbers are also marketed locally and sometimes exported to neighboring countries, particularly the Arab Gulf Emirates, as caged pets. Traditional control methods aimed at scaring or chasing birds from the crops, usually with noise-making devices, are costly; furthermore, they have largely been unsuccessful and time consuming because they require human patrolling before and after normal working hours. They provide at best only temporary relief. The aim of this study was to develop a new decoy trap based on the Modified Australian Crow Trap (MAC), which we propose to call the PAROTRAP, and to evaluate its effectiveness and potential in capturing live parakeets in the field as a possible solution to the parakeet problem, as well as promoting the economic exploitation of trapped parakeets for the pet trade. The study was undertaken during March and June 1979 as a part of the UNDP/FAO Project No. PAK/71/554, assisting Pakistan Vertebrate Pest Control Centre in developing and improving control techniques to prevent or reduce bird damage to important crops. Our earlier trials showed that parakeets could be induced to enter a conventionally designed MAC trap, and that after some time they learned how to escape from it. Therefore, a series of minor modifications were introduced and field tested.

The twenty-first century needs a better G20 and a new G7+. Bruegel Policy Contribution 2014/13, 14 November 2014

During the 2008 financial crisis, the G20 was hastily elevated to ‘global economic steering committee’. In the early stages of the crisis, the G20 was an effective forum for crisis containment. As the crisis has eased, however, the G20 has lost both direction and momentum. Governments and policymakers have felt less need to act in unison and have rather refocused on their national agendas, as is their duty and primary function. However, effective global governance is needed permanently, not just in crisis times. It is desirable to have more representative and effective global governance that, among other things, is equipped to prevent crises rather than just react to them. In an environment of rapid change in global patterns of trade and wealth creation, a new revamped (but highly representative) grouping should be created within the G20, to provide leadership on key economic policy matters. Euro-area members should give up their individual seats in this G7+, allowing room for China and other large emerging economies. Without euro-area countries taking such a step, it would be impossible to reconcile effectiveness and representation in this new G7+, which would take charge of decision making on global economic imbalances, financial and monetary issues. All existing G20 countries, including individual euro-area countries, would however remain in the G20, which could potentially expand and would remain the prime forum for discussion on all remaining matters at global level.

Bruvver Jim's baby,

Mode of access: Internet.

Lovers Walking in the Snow (Crow and Heron)

Suzuki Harunobu; 11 17/64 in.x 8 7/64 in.; woodcut (chuban) ink and color on paper, with embossing (karazuri)

Lovers Walking in the Snow (Crow and Heron)

Suzuki Harunobu; 11 17/64 in.x 8 7/64 in.; woodcut (chuban) ink and color on paper, with embossing (karazuri)

Giffe's new male quartet book : a choice collection of new secular quartets for male voices /

Includes index.

The life and adventures of James P. Beckwourth, mountaineer, scout, and pioneer, and chief of the Crow nation of Indians.

Mode of access: Internet.

Masks, with Jim's beast, Tides, Among the lions, The reason, The house;

Mode of access: Internet.

Jim Skeevers' object lessons on railroading for railroaders /

Mode of access: Internet.