Interpreting Empirical Assessments from a Behavioral Perspective: A Rationale for Why and How

This paper provides a rationale on why and how to utilize assessment tools effectively within the behavioral framework through idiographic assessment. Empirical assessment instruments can provide guidance to the behaviorist that may prove useful in the idiographic formation of a behaviorally-based treatment plan. The paper will focus on two of the major traditional instrument tools, the Minnesota Multiphasic Personality Inventory and the Rorschach inkblot test.

Assessment of internal quality attributes of mandarin fruit. 2. NIR calibration model robustness

The robustness of multivariate calibration models, based on near infrared spectroscopy, for the assessment of total soluble solids (TSS) and dry matter (DM) of intact mandarin fruit (Citrus reticulata cv. Imperial) was assessed. TSS calibration model performance was validated in terms of prediction of populations of fruit not in the original population (different harvest days from a single tree, different harvest localities, different harvest seasons). Of these, calibration performance was most affected by validation across seasons (signal to noise statistic on root mean squared error of prediction of 3.8, compared with 20 and 13 for locality and harvest day, respectively). Procedures for sample selection from the validation population for addition to the calibration population (‘model updating’) were considered for both TSS and DM models. Random selection from the validation group worked as well as more sophisticated selection procedures, with approximately 20 samples required. Models that were developed using samples at a range of temperatures were robust in validation for TSS and DM.

Determinants of vascular cognitive impairment : White matter lesions, brain atrophy and their neuropsychological correlates

The concept of vascular cognitive impairment (VCI) covers a wide spectrum of cognitive dysfunctions related to cerebrovascular disease. Among the pathophysiological determinants of VCI are cerebral stroke, white matter lesions and brain atrophy, which are known to be important risk factors for dementia. However, the specific mechanisms behind the brain abnormalities and cognitive decline are still poorly understood. The present study investigated the neuropsychological correlates of particular magnetic resonance imaging (MRI) findings, namely, medial temporal lobe atrophy (MTA), white matter hyperintensities (WMH), general cortical atrophy and corpus callosum (CC) atrophy in subjects with cerebrovascular disease. Furthermore, the cognitive profile of subcortical ischaemic vascular disease (SIVD) was examined. This study was conducted as part of two large multidisciplinary study projects, the Helsinki Stroke Aging Memory (SAM) Study and the multinational Leukoaraiosis and Disability (LADIS) Study. The SAM cohort consisted of 486 patients, between 55 and 85 years old, with ischaemic stroke from the Helsinki University Hospital, Helsinki, Finland. The LADIS Study included a mixed sample of subjects (n=639) with age-related WMH, between 65 and 84 years old, gathered from 11 centres around Europe. Both studies included comprehensive clinical and neuropsychological assessments and detailed brain MRI. The relationships between the MRI findings and the neuropsychological test performance were analysed by controlling for relevant confounding factors such as age, education and other coexisting brain lesions. The results revealed that in elderly patients with ischaemic stroke, moderate to severe MTA was specifically related to impairment of memory and visuospatial functions, but mild MTA had no clinical relevance. Instead, WMH were primarily associated with executive deficits and mental slowing. These deficits mediated the relationship between WMH and other, secondary cognitive deficits. Cognitive decline was best predicted by the overall degree of WMH, whereas the independent contribution of regional WMH measures was low. Executive deficits were the most prominent cognitive characteristic in SIVD. Compared to other stroke patients, the patients with SIVD also presented more severe memory deficits, which were related to MTA. The cognitive decline in SIVD occurred independently of depressive symptoms and, relative to healthy control subjects, it was substantial in severity. In stroke patients, general cortical atrophy also turned out to be a strong predictor of cognitive decline in a wide range of cognitive domains. Moreover, in elderly subjects with WMH, overall CC atrophy was related to reduction in mental speed, while anterior CC atrophy was independently associated with frontal lobe-mediated executive functions and attention. The present study provides cross-sectional evidence for the involvement of WMH, MTA, general cortical atrophy and CC atrophy in VCI. The results suggest that there are multifaceted pathophysiological mechanisms behind VCI in the elderly, including both vascular ischaemic lesions and neurodegenerative changes. The different pathological changes are highly interrelated processes and together they may produce cumulative effects on cognitive decline.

An assessment of creep deformation and fracture behavior of 2.25Cr-1Mo similar and dissimilar weld joints

The evaluation of the creep deformation and fracture behavior of a 2.25Cr-1Mo steel base metal, a 2.25Cr-1Mo/2.25Cr-1Mo similar weld joint, and a 2.25Cr-1Mo/Alloy 800 dissimilar weld joint at 823 K over a stress range of 90 to WO MPa has been carried out. The specimens for creep testing were taken from single-V weld pads fabricated by a shielded metal arc-welding process using 2.25Cr-1Mo steel (for similar-joint) and INCONEL 182 (for dissimilar-joint) electrodes. The weld pads were subsequently given a postweld hear treatment (PWHT) of 973 K for I hour. The microstructure and microhardness of the weld joints were evaluated in the as-welded, postweld heat-treated, and creep-tested conditions. The heat-affected zone (HAZ) of similar weld joint consisted of bainite in the coarse-prior-austenitic-grain (CPAG) region near the fusion line, followed by bainite in the fine-prior-austenitic-grain (FPAG) and intercritical regions merging with the unaffected base metal. In addition to the HAZ structures in the 2.25Cr-1Mo steel, the dissimilar weld joint displayed a definite INCONEL/2.25Cr-1Mo weld interface structure present either as a sharp line or as a diffuse region. A hardness trough was observed in the intercritical region of the HAZ in both weld joints, while a maxima in hardness was seen at the weld interface of the dissimilar weld joint. Both weld joints exhibited significantly lower rupture lives compared to the 2.25Cr-1Mo base metal. The dissimilar weld joint exhibited poor rupture life compared to the similar weld joint, at applied stresses lower than 130 MPa. In both weld joints, the strain distribution across the specimen gage length during creep testing varied significantly. During creep testing, localization of deformation occurred in the intercritical HAZ. In the similar weld joint, at all stress levels investigated, and in the dissimilar weld joint, at stresses greater than or equal to 150 MPa, the creep failure occulted in the intercritical HAZ. The fracture occurred by transgranular mode with a large number of dimples. At stresses below 150 MPa, the failure in the dissimilar weld joint occurred in the CPAG HAZ near to the weld interface. The failure occurred by extensive intergranular creep cavity formation.

An assessment of creep deformation and fracture behavior of 2.25Cr-1Mo

The evaluation of the creep deformation and fracture behavior of a 2.25Cr-1Mo steel base metal, a 2.25Cr-1Mo/2.25Cr-1Mo similar weld joint, and a 2.25Cr-1Mo/Alloy 800 dissimilar weld joint at 823 K over a stress range of 90 to WO MPa has been carried out. The specimens for creep testing were taken from single-V weld pads fabricated by a shielded metal arc-welding process using 2.25Cr-1Mo steel (for similar-joint) and INCONEL 182 (for dissimilar-joint) electrodes. The weld pads were subsequently given a postweld hear treatment (PWHT) of 973 K for I hour. The microstructure and microhardness of the weld joints were evaluated in the as-welded, postweld heat-treated, and creep-tested conditions. The heat-affected zone (HAZ) of similar weld joint consisted of bainite in the coarse-prior-austenitic-grain (CPAG) region near the fusion line, followed by bainite in the fine-prior-austenitic-grain (FPAG) and intercritical regions merging with the unaffected base metal. In addition to the HAZ structures in the 2.25Cr-1Mo steel, the dissimilar weld joint displayed a definite INCONEL/2.25Cr-1Mo weld interface structure present either as a sharp line or as a diffuse region. A hardness trough was observed in the intercritical region of the HAZ in both weld joints, while a maxima in hardness was seen at the weld interface of the dissimilar weld joint. Both weld joints exhibited significantly lower rupture lives compared to the 2.25Cr-1Mo base metal. The dissimilar weld joint exhibited poor rupture life compared to the similar weld joint, at applied stresses lower than 130 MPa. In both weld joints, the strain distribution across the specimen gage length during creep testing varied significantly. During creep testing, localization of deformation occurred in the intercritical HAZ. In the similar weld joint, at all stress levels investigated, and in the dissimilar weld joint, at stresses greater than or equal to 150 MPa, the creep failure occulted in the intercritical HAZ. The fracture occurred by transgranular mode with a large number of dimples. At stresses below 150 MPa, the failure in the dissimilar weld joint occurred in the CPAG HAZ near to the weld interface. The failure occurred by extensive intergranular creep cavity formation.

Does subjective rating reflect behavioural coding? Personality in 2 month-old dog puppies: An open-field test and adjective-based questionnaire

A number of studies have recently investigated personality traits in non-human species, with the dog gaining popularity as a subject species for research in this area. Recent research has shown the consistency of personality traits across both context and time for adult dogs, both when using questionnaire based methods of investigation and behavioural analyses of the dogs' behaviour. However, only a few studies have assessed the correspondence between these two methods, with results varying considerably across studies. Furthermore, most studies have focused on adult dogs, despite the fact that an understanding of personality traits in young puppies may be important for research focusing on the genetic basis of personality traits. In the current study, we sought to evaluate the correspondence between a questionnaire based method and the in depth analyses of the behaviour of 2-month old puppies in an open-field test in which a number of both social and non-social stimuli were presented to the subjects. We further evaluated consistency of traits over time by re-testing a subset of puppies. The correspondence between methods was high and test-retest consistency (for the main trait) was also good using both evaluation methods. Results showed clear factors referring to the two main personality traits 'extroversion,' (i.e. the enthusiastic, exuberant approach to the stimuli) and 'neuroticism,' (i.e. the more cautious and fearful approach to the stimuli), potentially similar to the shyness-boldness dimension found in previous studies. Furthermore, both methods identified an 'amicability' dimension, expressing the positive interactions the pups directed at the humans stranger, and a 'reservedness' dimension which identified pups who largely chose not to interact with the stimuli, and were defined as quiet and not nosey in the questionnaire.

Associations between Belief in Conspiracy Theories and the Maladaptive Personality Traits of the Personality Inventory for DSM-5

Conspiracy theories can be treated as both rational narratives of the world as well as outcomes of underlying maladaptive traits. Here, we examined associations between belief in conspiracy theories and individual differences in personality disorders. An Internet-based sample (N=259) completed measures of belief in conspiracy theories and the 25 facets of the Personality Inventory for DSM-5 (PID-5). Preliminary analyses showed no significant differences in belief in conspiracy theories across participant sex, ethnicity, and education. Regression analyses showed that the PID-5 facets of Unusual Beliefs and Experiences and, to a lesser extent, Suspiciousness, significantly predicted belief in conspiracy theories. These findings highlight a role for maladaptive personality traits in understanding belief in conspiracy theories, but require further investigation.

A comparison of electrophysiological changes during the sleep onset period of psychophysiological insomniacs, psychiatric insomniacs and normal sleepers

The EEG of the sleep onset period of psychophysiological insomniacs, psychiatric insomniacs and controls was compared using power spectral analysis (FFT). Eighteen drug-free subjects were equally divided into three groups according to their responses in the Brock Sleep and Insomnia Questionnaire, the Minnesota Multiphasic Personality Inventory and the Sleep Disorders Questionnaire. Group 1 consisted of psychophysiological insomniacs, group 2 included insomniacs with an indication of psychiatric disturbances, and group 3 was a control group. EEG, EOG and EMG were recorded for two consecutive nights. Power spectral analysis (FFT) of EEG at C4 from the sleep onset period (defined as lights out to the first five minutes of stage 2) was performed on all standard frequency bands, delta: .5-4 Hz; theta: 4-8 Hz; alpha: 8-12 Hz; sigma: 12-15 Hz beta: 15-25 Hz. Psychophysiological insomniacs had less alpha during wakefulness than the other two groups and did not show the dramatic drop in alpha across the sleep onset period, which characterizes normal sleep. They also had less delta, especially during stage 2 on night 2. They also showed less delta in the last quartile of the chronological analysis of the sleep onset period. Psychiatric insomniacs showed lower relative beta power values overall while psychophysiological insomniacs showed higher relative beta power values during wakefulness. This microanalysis 11 confirms that the sleep onset period is generally similar for psychiatric insomniacs and normal sleepers. This may be due to the sample of psychiatric insomniacs being heterogeneous or may reflect a sleep onset system that is essentially intact. Psychophysiological insomniacs have higher cortical arousal during the sleep onset period than do the psychiatric insomniacs and the controls. Clear differences in the sleep onset period of psychophysiological insomniacs exist. The dramatic changes in power values in these two groups are not seen in the psychophysiological insomniacs, which may make the discrimination between wakefulness and sleep more difficult.

Working memory in Alzheimer’s disease and mild cognitive impairment (MCI) : assessment and intervention

L’objectif principal de cette thèse est d’examiner et d’intervenir auprès des déficits de la mémoire de travail (MdeT) à l’intérieur de deux populations cliniques : la maladie d’Alzheimer (MA) et le trouble cognitif léger (TCL). La thèse se compose de trois articles empiriques. Le but de la première expérimentation était d’examiner les déficits de MdeT dans le vieillissement normal, le TCL et la MA à l’aide de deux versions de l’empan complexe : l’empan de phrases et l’empan arithmétique. De plus, l’effet de «l’oubli» (forgetting) a été mesuré en manipulant la longueur de l’intervalle de rétention. Les résultats aux tâches d’empan complexe indiquent que la MdeT est déficitaire chez les individus atteints de TCL et encore plus chez les gens ayant la MA. Les données recueillies supportent également le rôle de l’oubli à l’intérieur de la MdeT. L’augmentation de l’intervalle de rétention exacerbait le déficit dans la MA et permettait de prédire un pronostic négatif dans le TCL. L’objectif de la deuxième étude était d’examiner la faisabilité d’un programme d’entraînement cognitif à l’ordinateur pour la composante de contrôle attentionnel à l’intérieur de la MdeT. Cette étude a été réalisée auprès de personnes âgées saines et de personnes âgées avec TCL. Les données de cette expérimentation ont révélé des effets positifs de l’entraînement pour les deux groupes de personnes. Toutefois, l’absence d’un groupe contrôle a limité l’interprétation des résultats. Sur la base de ces données, la troisième expérimentation visait à implémenter une étude randomisée à double-insu avec groupe contrôle d’un entraînement du contrôle attentionnel chez des personnes TCL avec atteinte exécutive. Ce protocole impliquait un paradigme de double-tâche composé d’une tâche de détection visuelle et d’une tâche de jugement alpha-arithmétique. Alors que le groupe contrôle pratiquait simplement la double-tâche sur six périodes d’une heure chacune, le groupe expérimental recevait un entraînement de type priorité variable dans lequel les participants devaient gérer leur contrôle attentionnel en variant la proportion de ressources attentionnelles allouée à chaque tâche. Les résultats montrent un effet significatif de l’intervention sur une des deux tâches impliquées (précision à la tâche de détection visuelle) ainsi qu’une tendance au transfert à une autre tâche d’attention divisée, mais peu d’effets de généralisation à d’autres tâches d’attention. En résumé, les données originales rapportées dans la présente thèse démontrent un déficit de la MdeT dans les maladies neurodégénératives liées à l’âge, avec un gradient entre le TCL et la MA. Elles suggèrent également une préservation de la plasticité des capacités attentionnelles chez les personnes à risque de développer une démence.

La medida de la eficacia docente. Descripci??n y aplicaci??n del Minnesota Teacher Attitude Inventory : un instrumento predictor

Ofrecer una panor??mica que pretende incluir el fundamento de la evaluaci??n en general, su concreci??n en el ??mbito de la evaluaci??n del docente, es decir, de su eficacia describiendo modalidades e instrumentos de evaluaci??n y sus agentes. Analizar una de esas modalidades: Minnesota Teacher Attitude Inventory a partir de una experiencia concreta. Hip??tesis: A) La clasificaci??n ordinal atendiendo a los promedios obtenidos en las calificaciones de las asignaturas cursadas durante la carrera, no guardan correlaci??n significativa con las puntuaciones del Minnesota Teacher Attitude Inventory. B) Las calificaciones en la asignatura de Did??ctica obtenidas por los alumnos de segundo curso guardan correlaci??n con las puntuaciones en el MTAI. C) Las actitudes de los estudiantes de Magisterio frente a la Educaci??n, despu??s de haber realizado su per??odo largo de pr??cticas docentes -3 meses-, se modifican negativamente. Alumnos de los tres cursos de las Escuelas de Formaci??n del Profesorado de EGB de Barcelona y Tarragona (oficiales) y Blanquerna de Barcelona (no oficial), durante el mes de mayo de 1979. Definidos los planteamientos te??ricos se aplica el MTAI despu??s de haberle hecho unas adaptaciones formales para poderlo aplicar a nuestro contexto y confeccionar una hoja de respuestas m??s operativa y ??til para la correcci??n manual con plantilla. En base a unas hip??tesis y disponiendo de unos datos se analizan los resultados y se extraen las conclusiones pertinentes. Consultas personales, textos, documentos y revistas educativas. MTAI (mide las actitudes, prev?? las relaciones que se establecen en la clase y la satisfacci??n que el futuro educador obtendr?? de la Ense??anza como profesi??n). Tabulaci??n de los datos mediante puntuaciones medias globales, pol??gonos de frecuencias, correlaciones graduales y correlaciones lineales. Las puntuaciones obtenidas no se corresponden con las de los baremos americanos, la media en el baremo es de 59.5 y la de nuestros estudiantes apenas sobrepasa el 30. Hay una necesidad de adaptaciones y validaciones completas para pruebas de prestigio en otras ??reas geogr??ficas. El instrumento es ??til para servirse de ??l como referencia, a pesar de las deficiencias que implica la aplicaci??n directa e inmediata tras la traducci??n del original.

Grup d'entrenament en habilitats socials. 'Grupo de entrenamiento en habilidades sociales'.

Determinar los elementos que constituyen una conducta social. Determinar como se relacionan determinados aspectos de una conducta para producir una conducta social habilidosa.. 10 sujetos entre 18 y 30 años con nivel socio-cultural medio-alto y problemas de incorporación social.. Entrevista y evaluación en tres areas: ansiedad social, cognisciones y actuación propia. EMES_M, AI, SAD, FNE.. Entrevista de Arkowitz, 1981, Minnesota Multiphasic Personality Inventory, Sixteen Personality Factor Questionnaire, State-Trait Anxiety Inventory Beck Depression Inventary.. Gráficos de barras y circulares, tablas.. Los resultados se presentan a modo de gráficos. Existen vinculaciones dadas como significativas a través de un porcentaje que vincula un test a un aspecto de la personalidad, sin una más amplia definición.. Prueba básicamente empírica que engloba los resultados anteriores y posteriores a un adiestramiento en 'habilidades sociales'. Cualquier cuestionario es desglosado en función de los resultados significativos obtenidos en cada test..

Relaci??n entre el MMPI y el HSPQ en una muestra de adolescentes

Estudiar los factores de la personalidad mediante un estudio experimental. 141 sujetos de Las Palmas, 79 son chicas y 62 chicos. Todos realizan estudios en centros estatales de ense??anza media, en los cursos de COU, tercero y segundo de BUP. Ofrece unos presupuestos te??ricos centrados en la teor??a factorialista de Cattell y su af??n de estudiar cient??ficamente la personalidad, m??s una breve exposici??n de la nomenclatura y de la utilidad que tienen los dos tests que va a utilizar en el estudio experimental. Despu??s explica en qu?? consiste dicho estudio y concluye con los resultados obtenidos en un estudio de casos. Cuestionarios Hight School Personality Questionnaire (HSPQ) y Minnesota Multiphasic Personality Inventory (MMPI). Se aplican las pruebas HSPQ y MMPI y despu??s se analizan los resultados hallando la media del grupo femenino y la del masculino para obtener las diferencias existentes en la personalidad de ambos grupos. Para obtener mayor informaci??n sobre las dimensiones de la personalidad se realiza un estudio de casos. 1) En los resultados generales de grupo se deduce que: a) En las chicas se da una mayor sensibilidad e impaciencia, con ciertos sentimientos de inseguridad, reflejando sus problemas psicol??gicos a trav??s de la somatizaci??n; b) Los chicos poseen una mayor estabilidad emocional, son m??s dominantes y competitivos, dados a la acci??n y m??s resueltos en sus decisiones, aunque no se valoran en sus aut??nticas posibilidades. Mientras que los resultados en el estudio de casos: a) El perfil del sujeto femenino destaca por su gran iniciativa, optimismo, decisi??n, sociabilidad y no se encuentra atada por las costumbres sociales que le rodean, mostr??ndose rebelde con la autoridad, inconforme con el ambiente, agresiva e individualista. Adem??s presenta un Yo fuerte, estable, con ausencia de depresiones y con una normal preocupaci??n por la salud; b) El perfil masculino demuestra un sujeto acogedor y dispuesto a la cooperaci??n, con inteligencia general algo superior a la media. Tiene una considerable fuerza del Yo, es emocionalmente maduro y estable y con un temperamento bastante reflexivo. Pero presenta cierta dependencia del grupo y la b??squeda de aprobaci??n por un lado, y el deseo de autosuficiencia por otro. 1) La aplicaci??n del HSPQ ha permitido, por la asociaci??n con las escalas del MMPI, orientar de alguna manera las posibilidades cl??nicas de descripci??n de los factores de Cattell, a pesar de ser un test encaminado, m??s bien, a detectar la personalidad en sus formulaciones positivas de equilibrio y madurez. 2) Se confirma la orientaci??n bipolar de los factores del HSPQ, con las correlaciones positivas o negativas con el MMPI; al mismo tiempo que se apoyan o refutan las orientaciones positivas y negativas, respecto de la personalidad. 3) Igualmente en el MMPI, a trav??s de las correlaciones y sobre todo por medio del an??lisis factorial, se ha podido comprobar, c??mo no existe una enfermedad o desviaci??n psicopatol??gica por antonomasia, sino que se forma un conglomerado con todas ellas, aunque llevan un matiz definido.

Estudio teórico-práctico de la personalidad.

Estudiar la personalidad. 296 sujetos de Gijón, 191 son universitarios masculinos y 105 alumnas de sexto de bachillerato femenino. Expone unos presupuestos generales sobre la personalidad, analiza las teorías acerca de la misma, estudia científicamente la personalidad a través de la teoría de R.B. Cattell y de su cuestionario (HSPQ), y explica en qué consiste el Minnesota Multiphasic Personality Inventory (MMPI). Después realiza un trabajo experimental sobre la personalidad aplicando las pruebas citadas a estudiantes de Gijón. High School Personality Questionnaire (HSPQ) y Minnesota Multiphasic Personality Inventory (MMPI). La aplicación del HSPQ permite, por la asociación con las escalas de MMPI, comprobar de alguna manera las posibilidades clínicas de descripción de los factores de Cattell. 1) La histeria se da más en la muestra femenina, mientras que la psicastenia abunda en mayor medida en la masculina. 2) En la inteligencia, hay mayor dispersión entre los hombres, y hay mayor concentración sobre una media superior en las mujeres. 3) La estabilidad emocional favorece a las mujeres, mientras que la tensión aprensiva y la autosuficiencia destacan en los hombres. 1) El análisis factorial que se ha realizado sobre las variables de Cattell ha confirmado la línea de factores y de agrupaciones factoriales en notas de personalidad tal como las recoge, esencialmente, el manual. 2) Se ve confirmada la orientación bipolar de los factores HSPQ con las correlaciones positivas o negativas con el MMPI, al mismo tiempo que se destacan las orientaciones positivas o negativas, respecto de la personalidad, de las puntuaciones altas obtenidas en los diversos factores.

Estudo experimental sobre a precisão e validade dos escores introversão-extroversão de uma adaptação brasileira do Maudsley Personality Inventory de H.J. Eysenck

O propósito dos trabalhos experimentais expostos na presente dissertação foi o de estudar a versão brasileira do Maudaley Personality Inventory. de Eysench. no que diz respeito à sua dimensão bipolar introversão-extroversão. A adaptação brasileira (devida à Professora Riva Bauzer) foi aplicada por duas vezes a 70 estudantes, de quatro turmas do Colégio Batista Shepard, que são nossos alunos de psicologia. Paralelamente a esta aplicação, foi aplicado por duas vezes sucessivas, aos mesmos alunos, um questionário por nós organizado. Nele era pedida a cada um uma avaliação subjetiva do grau de introversão-extroversão dos respectivos colegas de classe. Desse modo tivemos a possibilidade de avaliar: a) o coeficiente de precisão do questionário; b) o coeficiente de precisão do Maudeley Personality Inventory; c) o coeficiente de validade do Maudaley Persona lity Inventory, tomando o questionário como critério de validação. Entretanto, nao terminaram ai nossos trabalhos. Por meio do coeficiente de correlação bisserial, foi estimado o poder discriminante de cada uma das questões do Maudsley Personality Inventory, assim como seu grau de "popularidade". Esta é uma denominação por nós atribuida à porcentagem de sujeitos que assinalaram a questão no sentido de extroversão. Estes elementos abrem caminho para a realização de pesquisas ulteriores com a finalidade de aperfeiçoar a versão brasileira do Maudsley Personality Inventory.

Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis

Pneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory. The aim of this study was to evaluate the effects of acute and extended administration of cannabidiol on pro-inflammatory cytokines and behavioral parameters in adult Wistar rats submitted to pneumococcal meningitis. Male Wistar rats underwent a cisterna magna tap and received either 10 mu l of sterile saline as a placebo or an equivalent volume of S. pneumoniae suspension. Rats subjected to meningitis were treated by intraperitoneal injection with cannabidiol (2.5, 5, or 10 mg/kg once or daily for 9 days after meningitis induction) or a placebo. Six hours after meningitis induction, the rats that received one dose were killed and the hippocampus and frontal cortex were obtained to assess cytokines/chemokine and brain-derived neurotrophic factor levels. On the 10th day, the rats were submitted to the inhibitory avoidance task. After the task, the animals were killed and samples from the hippocampus and frontal cortex were obtained. The extended administration of cannabidiol at different doses reduced the TNF-alpha level in frontal cortex. Prolonged treatment with canabidiol, 10 mg/kg, prevented memory impairment in rats with pneumococcal meningitis. Although descriptive, our results demonstrate that cannabidiol has anti-inflammatory effects in pneumococcal meningitis and prevents cognitive sequel. (C) 2012 Elsevier B.V. All rights reserved.