4-year clinical outcomes and predictors of repeat revascularization in patients treated with new-generation drug-eluting stents: a report from the RESOLUTE All-Comers trial (A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention)

OBJECTIVES The aim of the study was to investigate 4-year outcomes and predictors of repeat revascularization in patients treated with the Resolute zotarolimus-eluting stent (R-ZES) (Medtronic, Minneapolis, Minnesota) and XIENCE V everolimus-eluting stent (EES) (Abbott Vascular, Abbott Park, Illinois) in the RESOLUTE (A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention) All-Comers trial. BACKGROUND Data on long-term outcomes of new-generation drug-eluting stents are limited, and predictors of repeat revascularization due to restenosis and/or progression of disease are largely unknown. METHODS Patients were randomly assigned to treatment with the R-ZES (n = 1,140) or the EES (n = 1,152). We assessed pre-specified safety and efficacy outcomes at 4 years including target lesion failure and stent thrombosis. Predictors of revascularization at 4 years were identified by Cox regression analysis. RESULTS At 4 years, the rates of target lesion failure (15.2% vs. 14.6%, p = 0.68), cardiac death (5.4% vs. 4.7%, p = 0.44), and target vessel myocardial infarction (5.3% vs. 5.4%, p = 1.00), clinically-indicated target lesion revascularization (TLR) (7.0% vs. 6.5%, p = 0.62), and definite/probable stent thrombosis (2.3% vs. 1.6%, p = 0.23) were similar with the R-ZES and EES. Independent predictors of TLR were age, insulin-treated diabetes, SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score, treatment of saphenous vein grafts, ostial lesions, and in-stent restenosis. Independent predictors of any revascularization were age, diabetes, previous percutaneous coronary intervention, absence of ST-segment elevation myocardial infarction, smaller reference vessel diameter, SYNTAX score, and treatment of left anterior descending, right coronary artery, saphenous vein grafts, ostial lesions, or in-stent restenosis. CONCLUSIONS R-ZES and EES demonstrated similar safety and efficacy throughout 4 years. TLR represented less than one-half of all repeat revascularization procedures. Patient- and lesion-related factors predicting the risk of TLR and any revascularization showed considerable overlap. (A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention [RESOLUTE-AC]; NCT00617084).

Das Wiener Ghetto : seine Häuser und seine Bewohner. 1. das Judenviertel in der inneren Stadt bis zu seiner Aufhebung im Jahre 1421... 2. die Judenstadt im unteren Werd. 1625 - 1670. Mit 2 Pl. u. Textabb.

im Auftr. d. Hist. Komm. d. israelit. Kultusgemeinde in Wien bearb. von Ignaz Schwarz

Geschichte der Juden in Wien bis zum Jahre 1625

von Ignaz Schwarz

Geschichte der Juden in Wien : 1625 - 1740

von Max Grunwald

Die letzte Vertreibung der Juden aus Wien und Niederösterreich, ihre Vorgeschichte <1625 - 1670> und ihre Opfer

von David Kaufmann

Diese Figur ist in der größ vnd Höhe dreyviertel ein in einem Dorff bey Franckenthal Marsch genādt an einem Baum also auß der Erden gewachsen : funden 8, 18. February, auch vielen Herrschafften Communicirt vnd ist inen̄ Holl also gestalt gewessen Anno 1625

Bibliograph. Nachweis: Harms I,224

Eigentlicher Abriss der Baya Caditz, etc. : Wie solche von der Englischen Flotta im Monat Novemb. vergeblich angegriffen worden, 1625

Original sehr knapp beschnitten, Plattenrand nicht erkennbar

Procession, Weyland deß Durchleuchtigen, Hochgebornen Fürsten vnnd Herrn, Herrn Joachim Ernsten, Marggrafen zu Brandenburg ... Fürstl. LeichBegängnuß : wie dieselbe Montags den 25. Aprilis, Anno 1625 zu Onoltzbach ... angestellet worden ...

[Stechermonogramm, rechts unten:] GR [d.i. wohl Georg Restlein]

Giulio Eug.. Abrano Alary, Ganzfigurbildnis

Signatur des Originals: S 36/F00016

Horizontal profiles of longwave and shortwave radiation components over sea ice near Barrow, Alaska during the 2011 melt

An integrated instrument package for measuring and understanding the surface radiation budget of sea ice is presented, along with results from its first deployment. The setup simultaneously measures broadband fluxes of upwelling and downwelling terrestrial and solar radiation (four components separately), spectral fluxes of incident and reflected solar radiation, and supporting data such as air temperature and humidity, surface temperature, and location (GPS), in addition to photographing the sky and observed surface during each measurement. The instruments are mounted on a small sled, allowing measurements of the radiation budget to be made at many locations in the study area to see the effect of small-scale surface processes on the large-scale radiation budget. Such observations have many applications, from calibration and validation of remote sensing products to improving our understanding of surface processes that affect atmosphere-snow-ice interactions and drive feedbacks, ultimately leading to the potential to improve climate modelling of ice-covered regions of the ocean. The photographs, spectral data, and other observations allow for improved analysis of the broadband data. An example of this is shown by using the observations made during a partly cloudy day, which show erratic variations due to passing clouds, and creating a careful estimate of what the radiation budget along the observed line would have been under uniform sky conditions, clear or overcast. Other data from the setup's first deployment, in June 2011 on fast ice near Point Barrow, Alaska, are also shown; these illustrate the rapid changes of the radiation budget during a cold period that led to refreezing and new snow well into the melt season.