Cocaine and a changing brain : meeting summary : Ernest Morial Convention Center, New Orleans, LA, October 25, 1997 : sponsored by Division of Basic Research, National Institute on Drug Abuse, National Institutes of Health /

"January 1999"--P. [4] of cover.

National Institute on Drug Abuse, Medications Development Division /

Mode of access: Internet.

National Institute on Drug Abuse training grants directory.

Mode of access: Internet.

Changes in extracellular levels of glutamate in the nucleus accumbens after ethanol-induced behavioral sensitization in adolescent and adult mice

Repeated administration of low doses of ethanol gradually increases locomotor responses to ethanol in adult Swiss mice. This phenomenon is known as behavioral sensitization. However, we have shown that adolescent Swiss mice show either behavioral tolerance or no sensitization after repeated ethanol injections. Although the mesolimbic dopamine system has been extensively implicated in behavioral sensitization, several studies have demonstrated an important role of glutamatergic transmission in this phenomenon. In addition, relatively few studies have examined the role of developmental factors in behavioral sensitization to ethanol. To examine the relationship between age differences in behavioral sensitization to ethanol and the neurochemical adaptations related to glutamate within nucleus accumbens (NAc), in vivo microdialysis was conducted in adolescent and adult Swiss mice treated with ethanol (1.8 g/kg) or saline for 15 days and subsequently challenged with an acute dose (1.8 g/kg) of ethanol 6 days later. Consistent with previous findings, only adult mice demonstrated evidence of behavioral sensitization. However, ethanol-treated adolescent mice demonstrated a 196.1 +/- 40.0% peak increase in extracellular levels of glutamate in the NAc after ethanol challenge in comparison with the basal values, whereas ethanol-treated adult mice demonstrated a 52.2 +/- 6.2% reduction in extracellular levels of glutamate in the NAc after ethanol challenge. These observations suggest an age-dependent inverse relationship between behavioral and glutamatergic responses to repeated ethanol exposure. (C) 2011 Elsevier Inc. All rights reserved.

THE ALCOHOL TREATMENT PROFILE SYSTEM: ITS DEVELOPMENT AND AN EVALUATION OF ITS CAPABILITIES

The development of the Alcohol Treatment Profile System (ATPS) was described and an evaluation of its perceived value by various States was undertaken, The ATPS is a treatment needs assessment tool based on the unification of several large national epidemiologic and treatment data sets. It was developed by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and responsibility for its creation was given to the NIAAA's Alcohol Epidemiologic Data System (AEDS). The ATPS merges county-level measures of alcohol problem prevalence (the specially constructed AEDS Alcohol Problem Indicators), indicating "need" for treatment, and treatment utilization measures (the National Drug and Alcohol Treatment Utilization Survey), indicating treatment "demand." The capabilities of the ATPS in the unique planning and policy-making settings of several States were evaluated.^

Sentencing and dispositions of youth DUI and other alcohol offenses: a guide for judges and prosecutors.

Mode of access: Internet.

Progress and problems in treating alcohol abusers. Report to the Congress.

Mode of access: Internet.

Alcohol and alcohol safety. A curriculum manual for senior high level. Volume II of II. A teacher's activities guide.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and alcohol safety. A curriculum manual for elementary level. Volume II of II. A teacher's activities guide.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and alcohol safety. A curriculum manual for junior high level. Volume II of II. A teacher's activities guide.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and alcohol safety. A curriculum manual for senior high level. Volume I of II.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and alcohol safety. A curriculum manual for elementary level. Volume I of II.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and alcohol safety. A curriculum manual for junior high level. Volume I of II.

National Highway Traffic Safety Administration, Washington, D.C.

To establish a national center on child abuse and neglect. Hearings, Ninety-third Congress, first session, on H.R. 6379, H.R. 10552, and H.R. 10968 ...

Hearings held Oct. 1-Nov. 12, 1973.

Proceedings of the first National Conference on Child Abuse and Neglect, January 4-7, 1976 /

Mode of access: Internet.