(Table 1) Diagnostic characters of specimens of Marenzelleria bastropi sp. n., M. arctia, M. neglecta, M. viridis and M. wireni

Marenzelleria bastropi, a new species of Spionidae (Polychaeta) from the brackish water Currituck Sound, North Carolina, is described. The new species is characterized by the great number of chaetigers between the first neuro- and notopodial hooded hooks, the extension of the nuchal organ up to the end of chaetiger 2/middle of chaetiger 3 and the presence of about 60-90 branchiate chaetigers. Marenzelleria bastropi sp. nov. is closely related to M. neglecta (Sikorski and Bick, 2004) and Marenzelleria viridis (Verrill, 1873). Marenzelleria wireni Augener, 1913 is described here for the first time from western Spitsbergen. Adult specimens are investigated and compared with specimens from other areas of distribution. A key for subadult and adult specimens of all Marenzelleria species is provided.

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

In gene therapy to treat cancer, typically only a fraction of the tumor cells can be successfully transfected with a gene. However, in the case of brain tumor therapy with the thymidine kinase gene from herpes simplex virus (HSV-tk), not only the cells transfected with the gene but also neighboring others can be killed in the presence of ganciclovir. Such a "bystander" effect is reminiscent of our previous observation that the effect of certain therapeutic agents may be enhanced by their diffusion through gap junctional intercellular communication (GJIC). Herein, we present the evidence, from in vitro studies, that gap junctions could indeed be responsible for such a gene therapy bystander effect. We used HeLa cells for this purpose, since they show very little, if any, ability to communicate through gap junctions. When HeLa cells were transfected with HSV-tk gene and cocultured with nontransfected cells, only HSV-tk-transfected HeLa cells (tk+) were killed by ganciclovir. However, when HeLa cells transfected with a gene encoding for the gap junction protein, connexin 43 (Cx43), were used, not only tk+ cells, but also tk- cells were killed, presumably due to the transfer, via Cx43-mediated GJIC, of toxic ganciclovir molecules phosphorylated by HSV-tk to the tk- cells. Such bystander effect was not observed when tk+ and tk- cells were cocultured without direct cell-cell contact between those two types of cells. Thus, our results give strong evidence that the bystander effect seen in HSV-tk gene therapy may be due to Cx-mediated GJIC.

Georges de La Tour : the Status of Scholarship

Seventeenth-century French painter, Georges de La Tour, was a forgotten artist. His rediscovery in the nineteenth century set off a firestorm of research and a hunt to find more works by the artist. One problem after another arose as scholars attempted to define the artist by his works, his style, and the remnants of his personal history. There remains a volume of contradictory reports, authentication issues, and new scientific techniques which continue to influence study on the artist.

Zum zweihundertjèahrigen jubilèaum.

Disbound Original Held in Oak Street Library Facility.

A new French-English general dictionary : compiled from the French dictionaries of L'Académie, Bescherelle, Littré, etc., and the English dictionaries of Johnson, Webster, Richardson, etc., and the technical works in both languages ... /

Mode of access: Internet.

Causes celebres et interessantes, avec les jugemens qui les ont décidées : tome II /

Mode of access: Internet.

Causes celebres et interessantes, avec les jugemens qui les ont décidées : tome IV /

Mode of access: Internet.

Causes celebres et interessantes, avec les jugemens qui les ont décidées : tome V /

Mode of access: Internet.

Causes celebres et interessantes, avec les jugemens qui les ont décidées /

Mode of access: Internet.

Histoire generale des auteurs sacrés et ecclesiastiques ... /

Mode of access: Internet.

Histoire generale des auteurs sacrés et ecclesiastiques ... /

Mode of access: Internet.

Histoire générale des auteurs sacrés et ecclesiastiques ... /

Mode of access: Internet.

Histoire générale des auteurs sacrés et ecclésiastiques ... /

Mode of access: Internet.

Histoire generale des auteurs sacrés et ecclesiastiques ... /

Mode of access: Internet.

Histoire générale des auteurs sacrés et ecclesiastiques ... /

Mode of access: Internet.