Last Will and Testament of Owen Clifford (copy) of the Township of Grantham

Last Will and Testament of Owen Clifford (copy) of the Township of Grantham, Sept. 23, 1870.

Bond between Isaac Sterling of the Township of Salt fleet to William Dickson of Niagara and Thomas Clark of Queenston

Bond (1 page, printed) between Isaac Sterling of the Township of Salt fleet to William Dickson of Niagara and Thomas Clark of Queenston (regarding the Last Will and Testament of Robert Hamilton) for payment of 153 pounds, 12 shillings and 3 pence to be made to Dickson and Clark, May 21, 1819.

Bond between Archibald Johnston of the Township of Bertie to William Dickson of Niagara and Thomas Clark of Queenston

Bond (1 page, printed) between Archibald Johnston of the Township of Bertie to William Dickson of Niagara and Thomas Clark of Queenston (regarding the Last Will and Testament of Robert Hamilton) for payment of 75 pounds to be made to Dickson and Clark, June 7, 1821.

Bond between John Hammell of the Township of Dumphries, Halton County to William Dickson of Niagara

Bond (1 page, printed) between John Hammell of the Township of Dumphries, Halton County to William Dickson of Niagara for 117 pounds, 10 shillings and 10 pence, Sept. 21, 1824.

Bond between Alexander Fraser of the Township of Dumphries to the Honourable William Dickson of Galt

Bond (1 page, printed) between Alexander Fraser of the Township of Dumphries to the Honourable William Dickson of Galt for 304 pounds, June 21, 1830.

Province of Upper Canada Grant to the Honorable Peter Russell of the Township of Newark

Province of Upper Canada Grant to the Honorable Peter Russell of the Township of Newark. He is granted 150 acres in the Town of Newark in the County of Lincoln. This is registered in Liber B, folio 133. This was entered in the auditor’s office July 26, 1796. This document is held together with tape. The text is not affected, July 2, 1796.

Province of Upper Canada Grant (paper mounted on canvas) to the Honorable Peter Russell of the Township of Newark

Province of Upper Canada Grant (paper mounted on canvas) to the Honorable Peter Russell of the Township of Newark. He is granted 10 acres in the Township of Newark in the County of Lincoln. This document is mounted on canvas. This was entered in the auditor’s office Sept.29, 1797. Part of the paper document is missing but this does not affect the text, Sept. 1, 1797.

Province of Upper Canada Grant (vellum) to Joseph Mills of the township of Grimsby

Province of Upper Canada Grant (vellum) to Joseph Mills of the township of Grimsby, son of United Empire Loyalist John Mills, United Empire Loyalist. He was granted 200 acres in the 5th Concession in Windham in the County of Norfolk. This was registered in in Liber L, folio 387 on Feb. 14, 1803. The crown land seal is attached, but broken into small pieces, Nov. 25, 1802.

Province of Upper Canada Grant (vellum) to Christian Myers of the Township of Cornwall

Province of Upper Canada Grant (vellum) to Christian Myers of the Township of Cornwall, son of Michael Myers, United Empire Loyalist. He is granted 200 acres on Lot no. 18 in the 9th Concession in the Township of Mountain in the County of Dundas. This document is faded and part of the paper are missing or stained. Some of the text is affected. A small piece is missing from the crown land seal which is also faded. This was registered in Feb. 1803, Dec. 1, 1802

Province of Upper Canada Grant (vellum) to Peter McCollum of the Township of Grimsby

Province of Upper Canada Grant (vellum) to Peter McCollum of the Township of Grimsby, son of James McCollum, United Empire Loyalist. He was granted 200 acres in Lot no.12 in the 5th Concession in the Township of Scott in the County of Yorke. This was entered with the auditor on Nov. 17, 1809. There is a partial crown land seal attached to this document but it is broken, Nov. 16, 1809.

Province of Upper Canada Grant (vellum) to Thomas Fraser of the Township of Edwardsburgh granted 1 acre in Lot no.9 in the County of Stormont

Province of Upper Canada Grant (vellum) to Thomas Fraser of the Township of Edwardsburgh granted 1 acre in Lot no.9 in the County of Stormont. Signed by William Jarvis, Sir Isaac Brock, Prideaux Selby and John Macdonell. There are some holes in the document and there are small pieces missing on the right hand side. William Jarvis was the Provincial Secretary of the Lt. Governor of Upper Canada; Sir Isaac Brock. Jarvis was an officer in the Queen’s Rangers. He also served as Provincial Secretary of Upper Canada. A partial crown seal is attached, Mar. 26, 1812.

Data assimilation for marine monitoring and prediction: The MERCATOR operational assimilation systems and the MERSEA developments

During the past 15 years, a number of initiatives have been undertaken at national level to develop ocean forecasting systems operating at regional and/or global scales. The co-ordination between these efforts has been organized internationally through the Global Ocean Data Assimilation Experiment (GODAE). The French MERCATOR project is one of the leading participants in GODAE. The MERCATOR systems routinely assimilate a variety of observations such as multi-satellite altimeter data, sea-surface temperature and in situ temperature and salinity profiles, focusing on high-resolution scales of the ocean dynamics. The assimilation strategy in MERCATOR is based on a hierarchy of methods of increasing sophistication including optimal interpolation, Kalman filtering and variational methods, which are progressively deployed through the Syst`eme d’Assimilation MERCATOR (SAM) series. SAM-1 is based on a reduced-order optimal interpolation which can be operated using ‘altimetry-only’ or ‘multi-data’ set-ups; it relies on the concept of separability, assuming that the correlations can be separated into a product of horizontal and vertical contributions. The second release, SAM-2, is being developed to include new features from the singular evolutive extended Kalman (SEEK) filter, such as three-dimensional, multivariate error modes and adaptivity schemes. The third one, SAM-3, considers variational methods such as the incremental four-dimensional variational algorithm. Most operational forecasting systems evaluated during GODAE are based on least-squares statistical estimation assuming Gaussian errors. In the framework of the EU MERSEA (Marine EnviRonment and Security for the European Area) project, research is being conducted to prepare the next-generation operational ocean monitoring and forecasting systems. The research effort will explore nonlinear assimilation formulations to overcome limitations of the current systems. This paper provides an overview of the developments conducted in MERSEA with the SEEK filter, the Ensemble Kalman filter and the sequential importance re-sampling filter.

Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared

BACKGROUND: The provision of highly active antiretroviral therapy (HAART) in resource-limited settings follows a public health approach, which is characterised by a limited number of regimens and the standardisation of clinical and laboratory monitoring. In industrialized countries doctors prescribe from the full range of available antiretroviral drugs, supported by resistance testing and frequent laboratory monitoring. We compared virologic response, changes to first-line regimens, and mortality in HIV-infected patients starting HAART in South Africa and Switzerland. METHODS AND FINDINGS: We analysed data from the Swiss HIV Cohort Study and two HAART programmes in townships of Cape Town, South Africa. We included treatment-naïve patients aged 16 y or older who had started treatment with at least three drugs since 2001, and excluded intravenous drug users. Data from a total of 2,348 patients from South Africa and 1,016 patients from the Swiss HIV Cohort Study were analysed. Median baseline CD4+ T cell counts were 80 cells/mul in South Africa and 204 cells/mul in Switzerland. In South Africa, patients started with one of four first-line regimens, which was subsequently changed in 514 patients (22%). In Switzerland, 36 first-line regimens were used initially, and these were changed in 539 patients (53%). In most patients HIV-1 RNA was suppressed to 500 copies/ml or less within one year: 96% (95% confidence interval [CI] 95%-97%) in South Africa and 96% (94%-97%) in Switzerland, and 26% (22%-29%) and 27% (24%-31%), respectively, developed viral rebound within two years. Mortality was higher in South Africa than in Switzerland during the first months of HAART: adjusted hazard ratios were 5.90 (95% CI 1.81-19.2) during months 1-3 and 1.77 (0.90-3.50) during months 4-24. CONCLUSIONS: Compared to the highly individualised approach in Switzerland, programmatic HAART in South Africa resulted in similar virologic outcomes, with relatively few changes to initial regimens. Further innovation and resources are required in South Africa to both achieve more timely access to HAART and improve the prognosis of patients who start HAART with advanced disease.