Atorvastatin added to interferon beta for relapsing multiple sclerosis: a randomized controlled trial

Statins have anti-inflammatory and immunomodulatory properties in addition to lipid-lowering effects. The present study evaluated the effect of atorvastatin added to interferon beta-1b in multiple sclerosis (MS) in a multicenter, randomized, parallel-group, rater-blinded study performed in eight Swiss hospitals. Seventy-seven patients with relapsing-remitting MS started interferon beta-1b every other day. After 3 months, they were randomized 1:1 to receive atorvastatin 40 mg/day or not in addition to interferon beta-1b until month 15. The primary endpoint was the proportion of patients with new lesions on T2-weighted images at month 15 compared to baseline at month three. At study end, the proportion of patients with new lesions on T2-weighted images was equal in both groups (odds ratio 1.14; 95 % CI 0.36-3.56; p = 0.81). All predefined secondary endpoints including number of new lesions and total lesion volume on T2-weighted images, total number of new Gd-enhancing lesions on T1-weighted images, total brain volume, volume of grey matter, volume of white matter, EDSS, MSFC, relapse rate, time to first relapse, number of relapse-free patients and neutralizing antibodies did not show any significant differences (all p values >0.1). Transient elevations of liver enzymes were more frequent with atorvastatin (p = 0.02). In conclusion, atorvastatin 40 mg/day in addition to interferon beta-1b did not have a beneficial effect on relapsing-remitting MS compared to interferon beta-1b monotherapy over a 12-month period.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 969 - Rezension der Publikation von Ferdinand Fellner von Feldegg

u.a. Philosophie; Welt als Wille und Vorstellung;

Ms.Ff.F.Stoltze 3. 199 - Brief von Niclas Müller an Friedrich Stoltze

Stoltze: Gedichte, Heinrich Stoltze, Über dessen fehlerhafte Orthographie, Justinus Kerner, Stoltze, Persönliche Nachrichten

Ms.Ff.F.Stoltze 3. 389 - Brief von Friedrich Stoltze an Niclas Müller

Heinrich Stoltze, Dank für dessen Aufnahme, Politische Bemerkungen, Otto von Bismarck, Carl Mayer, Gedicht für den Frankfurter Liederkranz, Deutsches Bundesschießen

Ms.Ff.F.Stoltze 3. 601 - Brief von Heinrich Stoltze an Lyda Stoltze

Berufspläne, Der wahre Jakob, Politische Bemerkungen, Ferdinand Freiligrath, Napoleon III, Amerikanische Presse, Frankfurter Latern

Letters from Timothy Pickering to his brother and father, 1797-1798

These two handwritten letters by Timothy Pickering were written on February 14, 1797 and June 14, 1798 to his brother John Pickering and his father Timothy Pickering, respectively. The letter to his brother, John, discusses mutual friends, classmate Thomas Lee, and John’s recent attendance at a sermon by Dr. Joseph Priestley. The letter from Timothy to his father includes a discussion of Timothy’s expenses and the amount of money needed to pay his debts, a request for new shoes for commencement, the news of Timothy’s invitation to join honor society Phi Beta Kappa, and a few comments on his forensics course at Harvard.

Geschichte Frankreichs im revolutionszeitalter,

The "Register" has special t.-p. and separate paging.

Konrad Ferdinand Meyer,

Port. on cover.

Heinrich Suso's genannt Amandus Leben und Schriften /

Bibliographical footnotes.

Heinrich Zschokke, geschildert nach seinen vorzüglichsten lebensmomenten und seinen schriften.

Mode of access: Internet.

Fragmenta Theotisca : versionis antiquissimae evangelii S. Matthaei et aliquot homiliarum : e membranis monseensibus Bibliothecae Palatinae Vindobonensis /

Includes index.

Der arme Heinrich, zu vorlesungen und zum schulgebrauch,

Mode of access: Internet.