Makers of American history: The Lewis & Clark exploring expedition, 1804-,06,

Mode of access: Internet.

Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes

ABH and Lewis antigen expression has been associated with cancer development and prognosis, tumor differentiation, and metastasis. Considering that invasive ductal breast carcinoma (IDC) presents multiple molecular alterations, the aim of the present study was to determine whether the polymorphism of ABO, Lewis, and Secretor genes, as well as ABO phenotyping, could be associated with tumor differentiation and lymph nodes metastasis. Seventy-six women with IDC and 78 healthy female blood donors were submitted to ABO phenotyping/genotyping and Lewis and Secretor genotyping. Phenotyping was performed by hemagglutination and genotyping by the polymerase chain reaction with sequence-specific primers. ABO, Lewis, and Secretor genes were classified by individual single nucleotide polymorphism at sites 59, 1067, 202, and 314 of the Lewis gene, 428 of the Secretor gene, and 261 (O1 allele), 526 (O2 and B allele), and 703 (B allele). No association was found between breast cancer and ABO antigen expression (P = 0.9323) or genotype (P = 0.9356). Lewis-negative genotype was associated with IDC (P = 0.0126) but not with anatomoclinical parameters. Nonsecretor genotype was associated with axillary lymph node metastasis (P = 0.0149). In conclusion, Lewis and Secretor genotyping could be useful to predict respectively breast cancer susceptibility and axillary lymph nodes metastasis.

Receipt for items shipped by Gardner and Clark

Receipt for items shipped by Gardner and Clark for lake freight which was received in St. Catharines on July 18, 1876. This is signed by John Cassidy, July 10, 1876.

Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes

ABH and Lewis antigen expression has been associated with cancer development and prognosis, tumor differentiation, and metastasis. Considering that invasive ductal breast carcinoma (IDC) presents multiple molecular alterations, the aim of the present study was to determine whether the polymorphism of ABO, Lewis, and Secretor genes, as well as ABO phenotyping, could be associated with tumor differentiation and lymph nodes metastasis. Seventy-six women with IDC and 78 healthy female blood donors were submitted to ABO phenotyping/genotyping and Lewis and Secretor genotyping. Phenotyping was performed by hemagglutination and genotyping by the polymerase chain reaction with sequence-specific primers. ABO, Lewis, and Secretor genes were classified by individual single nucleotide polymorphism at sites 59, 1067, 202, and 314 of the Lewis gene, 428 of the Secretor gene, and 261 (O1 allele), 526 (O2 and B allele), and 703 (B allele). No association was found between breast cancer and ABO antigen expression (P = 0.9323) or genotype (P = 0.9356). Lewis-negative genotype was associated with IDC (P = 0.0126) but not with anatomoclinical parameters. Nonsecretor genotype was associated with axillary lymph node metastasis (P = 0.0149). In conclusion, Lewis and Secretor genotyping could be useful to predict respectively breast cancer susceptibility and axillary lymph nodes metastasis.

The journal of Lewis and Clarke to the mouth of the Columbia River beyond the Rocky Mountains in the years 1804-5, & 6 : giving a faithful description of the river Missouri and its source - of the various tribes of Indians through which they passed - manners and customs - soil - climate -commerce - gold and silver mines - animal and vegetable productions, &c.

Mode of access: Internet.

List of degrees granted at Clark university and Clark college, 1889-1914 /

Mode of access: Internet.

Genealogies of the Lewis and kindred families,

Mode of access: Internet.

History of Catholicity in New Albany and Jeffersonville, and Floyd and Clark counties, Ind. /

Mode of access: Internet.

A reconnaissance of the water resources of the Clearwater Plateau, Nez Perce, Lewis and northern Idaho counties, Idaho /

Bibliography: p. 27-28.

Memoir, historical and political, on the northwest coast of North America, and the adjacent territories : illustrated by a map and a geographical view of those countries.

References: Howes, U.S.IANA, no. G.389.

Savannah river and Clark Hill reservoir, Ga. and S.C. Hearings, Seventy-seventh Congress, first session. March 13, 14, and 18, 1941.

Mode of access: Internet.

RAGBRAI Learn about the Land; Day 7, July 2008

Iowa’s land was mapped long before it was declared a state. Since Lewis and Clark published their journey across the North American west in 1814, many different uses for maps have been found. Today there are maps of Iowa’s roads, waterways, landscape features, geology, and land use. One of the more recent mapping efforts has involved using a technology called LiDAR. This technology creates a topographic map of Iowa’s elevation that is accurate to within eight inches, ten times higher resolution than in previous elevation maps.