How can Biotherm grow in the selective skincare channel in Portugal?

Branding Lab

Intravital visualization of hematopoietic stem cell and neutrophil behavior in long bones of mice

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2011

Hoher prognostischer Wert der hTERT-Expression in Gastrointestinalen Stromatumoren

Magdeburg, Univ., Medizin. Fakultät, Diss., 2009

Implementierungslücke überwinden : Erfolgsfaktoren für nachhaltige Schulentwicklung und organisationstheoretische Lösungskonzeptionen, inspiriert durch die Futurum-Schule in Schweden

Schulentwicklung, Organisationsentwicklung, Change Management, Implementierungslücke, schwedisches Schulsystem, Rahmenbedingungen

Bedeutung der Helicobacter pylori-induzierten Cathepsin X-Expression für die Magenkarzinogenese : Untersuchung am transgenen Mausmodell

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2013

Ermittlung von Verschleiß bei kraftstoffgeschmierten Stahl-DLC-Gleitpaarungen

Magdeburg, Univ., Fak. für Maschinenbau, Diss., 2013

Untersuchungen zur Lebensqualität, Depressivität und Krankheitsverarbeitung von Hämodialysepatienten

Magdeburg, Univ., Med. Fak., Diss., 2014

Was Kinder im Alter von sechs bis zehn Jahren über Partizipation denken : eine qualitative Untersuchung

[s.c.]

Zoo 2.0“ – Die optimale Unternehmensdarstellung und Kundenbindung im größten sozialen Netzwerk Facebook

Die vorliegende Arbeit beleuchtet die Möglichkeiten des Web 2.0 als Instrument der Öffentlichkeitsarbeit, mit speziellem Fokus auf die entsprechenden Potenziale von Facebook. Es wird untersucht, wie drei ausgewählte Zoos diese Palette an Möglichkeiten nutzen und sich den Nutzern präsentieren: Spiegeln sie die vier Hauptaufgaben eines Zoos – Erholung/Unterhaltung, Bildung, Natur- und Artenschutz sowie Forschung – inhaltlich auf dem sozialen Netzwerk wider? Und letztlich wird die Frage geklärt, ob Facebook für die PR eines Zoos ein Muss ist oder es besser heißen sollte: zurück zur althergebrachten Pressearbeit.

PassPork : Nachweis von pathogenen Keimen in Schweinefleisch

PassPork ist eine neuartige Methode zum Nachweis von pathogenen Keimen in Schweinefleisch. Oftmals sind mikrobielle Nachweismethoden langwierig, kostenintensiv oder zu komplex, aus diesem Grund haben sich europäische Forschungslabore zusammengeschlossen und an einer kostengünstigen, einfachen, schnellen und sensitiven Nachweismethode gearbeitet. Die PassPork-Methode arbeitet nach dem Lateral-Flow-Prinzip und somit besteht der Test aus einem LFD, in welches die Probe eingeführt wird und einem Reader, der die Proben auswerten kann. Alle Schritte von der Probenentnahme am Schlachthof, über die Probenpräparation im Labor und der Probenauswertung sollen validiert werden. Die Validierung erfolgt in drei Testreihen. Hierfür wird die PassPork-Methode mit klassischen Methoden verglichen. Ein weiterer Bestandteil der Arbeit ist die Bestimmung des Detektionslimits, welches mit Hilfe von Glycerinkulturen ermittelt wird. Die Auswertung der Ergebnisse zeigt, dass die Methode derzeit noch zu unausgereift ist und Potential zur Optimierung besitzt. Die Methode kann in diesem Augenblick keine bestehenden, diagnostischen Schnellnachweismethoden ersetzten.

Blended learning - die neue Rolle der Ausbilder

Anja Schulz & Marcel Martsch

Schistosoma mansoni: control of female fertility by the male

We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.

Las Imágenes del malestar. Representaciones del yo y la construcción de subjetividad en la producción audiovisual contemporánea y en los nuevos dispositivos tecnológicos

El tema de la investigación propuesto aquí, se centra en el malestar social, y la representación de éste desde un punto de vista personal y autobiográfico, algo que en estas página denomino Autorepresentación del malestar social. ¿Cómo se autorepresenta el malestar y qué prácticas artísticas se emplean para ello? ¿Cuáles son la transformaciones que provocan estas prácticas artísticas en el terreno audiovisual? En este sentido, exploraremos dos vías de análisis: por un lado nos interesa observar cuales han sido las modificaciones que el poder ha desarrollado para establecer nuevas formas de explotación, y por otro lado, veremos como estas modificaciones están generando una nueva praxis social donde las prácticas artísticas cobran un nuevo y reforzado sentido, así como una nueva capacidad política, individual y colectiva a un mismo tiempo, cargada de una fuerza transformadora capaz de componer nuevos espacios de sujeto. Analizaremos, desde la representación del yo en la vida cotidiana, el género y las relaciones interpersonales, hasta las transformaciones contemporáneas del trabajo, y los cambios en la construcción de la subjetividad. El principal elemento en el que se apoyaran nuestras investigaciones será el anàlisis de producciones audiovisuales contemporáneas y la distribución de estas en algunas de las redes de comunicación contemporáneas, intentando mostrar, de esta manera, la interacción y los efectos directos que provocan en la realidad social.

Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study.

Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study. Design Combination of prospective cohort study with representative population based data on alcohol exposure. Setting Eight countries (France, Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Denmark) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Participants 109 118 men and 254 870 women, mainly aged 37-70. Main outcome measures Hazard rate ratios expressing the relative risk of cancer incidence for former and current alcohol consumption among EPIC participants. Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer. Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women. Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer.

Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study

Objective. To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. Design Nested case-control study. Setting. The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries. Participants: 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controls. Main outcome measures. Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders. Results. 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend <0.001). Compared with a pre-defined mid-level concentration of 25-(OH)D (50.0-75.0 nmol/l), lower levels were associated with higher colorectal cancer risk (<25.0 nmol/l: incidence rate ratio 1.32 (95% confidence interval 0.87 to 2.01); 25.0-49.9 nmol/l: 1.28 (1.05 to 1.56), and higher concentrations associated with lower risk (75.0-99.9 nmol/l: 0.88 (0.68 to 1.13); ≥100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P<0.001). Subgroup analyses showed a strong association for colon but not rectal cancer (P for heterogeneity=0.048). Greater dietary intake of calcium was associated with a lower colorectal cancer risk. Dietary vitamin D was not associated with disease risk. Findings did not vary by sex and were not altered by corrections for season or month of blood donation. Conclusions The results of this large observational study indicate a strong inverse association between levels of pre-diagnostic 25-(OH)D concentration and risk of colorectal cancer in western European populations. Further randomised trials are needed to assess whether increases in circulating 25-(OH)D concentration can effectively decrease the risk of colorectal cancer.