Harris, Ruth Portraits Women

OSP-Dup-1

Contact sheet of portraits of George Victor Wolff Portraits; Men

Digital Image

Portrait of George Louis Wolff (Gerd Ludwig Wolff) holding a mouse in his genetics laboratory; Little Rock, Arkansas.

Digital Image

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10−9 to P = 1.8 × 10−40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Lola and George Gruenthal in Neu-Ulm Portraits Family

"When will you come back?" (written in German on verso)

George Gruenthal as a child Portraits Children

Son of Max and Lola Gruenthal

Curves on threefolds and a conjecture of Griffiths-Harris

We prove that any arithmetically Gorenstein curve on a smooth, general hypersurface of degree at least 6, is a complete intersection. This gives a characterisation of complete intersection curves on general type hypersurfaces in . We also verify that certain 1-cycles on a general quintic hypersurface are non-trivial elements of the Griffiths group.