988 resultados para Guerra carlista, 1833-1840


Relevância:

100.00% 100.00%

Publicador:

Resumo:

Desarrollo de la obra y pensamiento tradicional del catal??n Jaime Balmes en materia filos??fica y pol??tica, ubicado en el panorama nacional de la Segunda Guerra Carlista, agravado especialmente en Catalu??a por la crisis agraria e industrial de 1846.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Previous genetic and functional studies have implicated the human endogenous retrovirus K (HERV-K) dUTPase located within the PSORS1 locus in the major histocompatibility complex region as a candidate psoriasis gene. Here, we describe a variant discovery and case-control association study of HERV-K dUTPase variants in 708 psoriasis cases and 349 healthy controls. Five common HERV-K dUTPase variants were found to be highly associated with psoriasis, with the strongest association occurring at the missense single-nucleotide polymorphism (SNP) rs3134774 (K158R, P=3.28 x 10(-15), odds ratio = 2.36 (95% confidence interval: 1.91-2.92)). After adjusting the association of the HERV-K dUTPase variants for the potential confounding effects of HLA alleles associated with psoriasis, the HERV-K SNPs rs9264082 and rs3134774 remained significantly associated. Haplotype analysis revealed that HERV-K haplotypes containing the non-risk alleles for rs3134774 and rs9264082 significantly reduced the risk of psoriasis. Functional testing showed higher antibody responses against recombinant HERV-K dUTPase in psoriasis patients compared with controls (P<0.05), as well as higher T-cell responses against a single HERV-K dUTPase peptide (P<0.05). Our data support an independent role for the HERV-K dUTPase on psoriasis susceptibility, and suggest the need for additional studies to clarify the role of this dUTPase in the pathogenesis of psoriasis. Journal of Investigative Dermatology (2012) 132, 1833-1840; doi:10.1038/jid.2012.69; published online 22 March 2012

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Contiene: T. I: ABA-CHI (544 p.)-- T. II: CHL-GLU (574 p.)--T. III: GOM-PAN (603 p.) -- T. IV: PAN-ZIN (675 p.)

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Mode of access: Internet.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Mode of access: Internet.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

pt. 2. Shurat ha-din -- pt. 3. Ḥizuḳ ha-Torah -- pt. 4. Dorshe ha-dorot.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Mode of access: Internet.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Provenance: University of Illinois Library bookplate "From the library of Conte Antonio Cavagna Sangiuliani di Gualdana Lazelada di Bereguardo, purchased 1921" on front paste-down; purchased from Count Antonio Cavagna, 1921.

Relevância:

40.00% 40.00%

Publicador:

Resumo:

La mencionada batalla se produjo en 1839